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The Apoptosis according to the Processing Irradiation and The Tumor Necrosis Factor

종양괴사인자와 방사선이 세포자멸사에 미치는 영향

Lee, Jaeseob;Jang, Seongjoo
이재섭;장성주

  • Received : 2016.03.21
  • Accepted : 2016.04.25
  • Published : 2016.04.30

Abstract

Acute promyelocytic leukemia(APL) is not just the poor grades of treating a type of blood cancer hayeoteul combination with chemotherapy despite concurrent radiation therapy are known to exhibit a greater effect and also works on normal cells to result in side effects. In this study, when after treatment with gamma rays, such as $TNF-{\alpha}$ in order to reduce these side effects was confirmed how affected the cell death of normal cells and cancer cells. HL-60 cells were used as the APL cell line HL-60 cells were differentiated with DMSO for treatment are shown the properties of normal granulocytes was used as a control group. As a result, HL-60 cells treated with $TNF-{\alpha}$ and gamma rays with only showed a cytotoxic effect by inducing the apoptosis cells were put to death. Consequently, $TNF-{\alpha}$ is thought to active substances that can increase the efficiency of cancer treatment to increase the removal of cancer cells when used with low-density gamma-ray treatment in order to eliminate the side effects of chemotherapy.

Keywords

Acute promyelocytic leukemia;gamma ray;Tumor Necrosis Factor;Apoptosis

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