A Case of Pemphigus vulgaris with Generalized Pruritus

전신소양감을 동반한 심상성 천포창 치험 1례

Lee, Sung-Eun;Yoon, Hwa-Jung;Ko, Woo-Shin

  • Received : 2016.04.14
  • Accepted : 2016.05.17
  • Published : 2016.05.25


Objectives : The purpose of this report is to know the effect of Korean medical treatments on pemphigus vulgaris with generalized pruritus. Methods : We treated a 44-years-old woman patient with pemphigus vulgaris on the whole body with Korean medicine. After Korean medical treatment for 17 weeks, we measured the extinction of blisters and decrease of pruritus. We recorded pictures of changes on symptoms. Results & Conclusions : The symptoms of pemphigus vulgaris were significantly improved. The blisters and itching were decreased and skin damages were almost recovered. Thus Korean medical treatments are effective on pemphigus vulgaris.


Pemphigus vulgaris;Generalized Pruritus;Korean medical treatment


  1. Stanldy JR, Freedberg IM, Eizen AZ, Wolff K, Austen KF, Goldsmith LA, et al. Fitzpatrick's dermatology in general medicine. 6th ed. New York:McGraw-Hill. 2003:558-67.
  2. Kim BD, Kim SC. Clinical study of Korean patients with pemphigus. Kor J Dermatol. 2005;43(8):1077-84.
  3. Seo HS, Yoon HJ. Text of Traditional Korean Dermatolog&Surgery. J Korean Med Ophthalmol Otolaryngol Dermatol. 2007:400-3.
  4. Lee CW. Autoimmune diseases of the skin. 1st ed. Seoul:Academia. 2002:9-42.
  5. Katz SL. Blistering skin disease. N Engl J Med. 1985;313:1657-8.
  6. McCuin JB, Hanlon T, Mutasim DF. Autoimmune bullous disease: diagnosis and management. Dermatol Nurs. 2006;18:20-5.
  7. GammonWR, Fine JD, Forbes M, Briggaman RA. Immuno-flourescence on split skin for the detection and differentiation of basement membrane zone autoantibodis. J Am Acad Dermatol. 1992;27:79-87.
  8. Udey MC, Stanley JR. Pemphigus-disease of antidesmosomal autoimmunity. JAMA. 1999;282:572-6.
  9. Amagai M. Autoimmunity against desmosomal cadherins in pemphigus. J Dermatol Sei. 1999;20:92-102.
  10. Amagai M, Klaus-Kovtun V, Stanley JR. Autoantibodis against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell. 1991;67:869-77.
  11. Stanley JR. Update; structure and function of pemphigus vulgaris antigen. J Dermatol. 1997;24:741-3.
  12. Lo ML, Pannone G, Staibano S, Mignogna MD, Rubini C, Farronato G, et al. Strict correlation between uPAR and plakoglobin expression in pemphigus vulgaris. J Cutan Pahol. 2002;29:540-8.
  13. Esaki C, Seishima M, Yamada T, Osada K, Kitajima Y. Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-triphophate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-2 cells, a squamous cell carcinoma line. J Invest Dermatol. 1995;105:329-33.
  14. Puviani M, Marconi A, Cozzani E, Pincelli C. Fas ligand in pemhigus sera induces keratinocyte apoptosis through the activation of caspase-8. J invest Dermatol. 2003;120:164-7.
  15. Wang X, Bregegere F, Frusic-Zlotkin M, Feinmesser M, Michel B, Milner Y. Possible apoptotic mechanism in epidermal cell acantholysis induced by pemphigus vulgaris autoimmunoglobulins. Apoptosis. 2004;9:131-43.
  16. Frusic-Zlotkin M, Pergamentz R, Michel B, David M, Minouni D, Bregegere F, et al. The interaction of pemphigus autoimmunoglobulins with epidermal cells: activation of the fas apoptotic pathway and the use of caspase activity for pathogenicity tests of pemphigus patients. Ann NY Acad Sei. 2005;1050:371-9.
  17. Roh BH, Whang KU, Cho MK, Park UL, Lee JS, Lee CW. A Study of apoptosis in pemphigus vulgaris. Korean J Dermatol. 2007;45(7):650-8.
  18. Hashimoto K, Shafran KM, Webber PS, Singer KH. Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cell; A mechanism for the loss of epidermal cohesion and blister formation. J Exp. 1983;157:259.
  19. Lee SS, Oh HS, Lee MH, Kim NI, Haw CR. A case of pemphigus vulgaris associated with eye involvement. The journal of Kyung Hee University medical center. 1987;3(4):558-63.
  20. Bystryn JC. Adjuvant therapy of pemphigus. Arch Dermatol. 1984;120:941.
  21. Lever WF, Schaunburg LG. Treatment of pemphigu vularis. Arch Dermatol. 1984;120:44.
  22. Park BS, Chung JH. Treatment of pemphigus. Korean J Dermatol. 1997;35:465-74.
  23. Seo PG, Choi WW, Chung JH. Pemphigus in Korea: clinical manifestations and treatment protocol. J Dermatol. 2003;30:782-8.
  24. Huilgol SC, Black MM. Management of the immunobullous disorders Ⅱ, Pemphigus. Clin Exp Dermatol. 1995;20:283-93.
  25. Carson PJ, Hameed A, Ahmed AR. Influence of treatment on the clinical course of pemphigus vulgaris. J Am Acad Dermatol. 1996;34:645-52.
  26. Heo J. DongEuiBoGam. Seoul:Dongeuibogamchulpansa. 2010:831,727,464,314.