DOI QR코드

DOI QR Code

Preparation of Positively and Negatively Charged Carbon Nanotube-Collagen Hydrogels with pH Sensitive Characteristic

양전하와 음전하를 띄며 pH 감응성인 카본나노튜브-콜라젠 Hydrogel의 합성

  • Received : 2015.12.31
  • Accepted : 2016.03.18
  • Published : 2016.06.20

Abstract

In this study, preparation of positively and negatively charged carbon nanotube (CNT)-collagen (CG) hydrogels with pH sensitive characteristic was reported. The positive and negative characteristics of the prepared hydrogels were created by introduction of positively functionalized CNT-NH2 and negatively functionalized CNT-COOH, respectively, into the collagen hydrogel. The surface charge of CNTs (CNT-NH2 and CNT-COOH), CG and CNTs/CG hydrogels was measured by Zetasizer. The swelling ratios of CNT-NH2/CG and CNT-COOH/CG hydrogels in aqueous solution were checked by measuring of weight changes of the hydrogels in the range of pH 2~10. In detail, the positively charged CNT-NH2/CG hydrogel swelled up to 5% at pH 4 in comparison to the weight at pH 7, while the negatively charged CNT-COOH/CG hydrogel swelled up to 10% at pH 10. The prepared CNT-NH2/CG and CNT-COOH/CG hydrogels will be very useful as pH sensitive oral drug-delivering systems for gastrointestine (pH ~2) and small intestine (pH ~9), respectively.

Keywords

Oral drug carrier;pH sensitive;Collagen;CNTs;Hydrogel

References

  1. Chugh, I.; Seth, N.; Rana, A. C.; Gupta, S. International Research Journal of Pharmacy 2012, 5, 57.
  2. Bhagwat, R. R.; Vaidhya, I. S. International Research Journal of Pharmacy Science and Research 2013, 4, 970.
  3. Vinay, K.; Prajapati, S. K.; Girish, C. S.; Mahendra, S.; Neerajkumar. World Journal of Pharmacy and Pharmaceutical Sciences 2012, 1, 934.
  4. Balamuralidhara, V.; Pramodkumar, T. M.; Srujana, N.; Venkatesh, M. P.; Gupta, N. V.; Krishana, K. L.; Ganagadharappa, H. V. American Journal of Drug Discovery and Development 2011, 1, 24. https://doi.org/10.3923/ajdd.2011.24.48
  5. Michael, C. K.; Joseph, F. G.; Malvika, G.; Annie , Z.; Nicholas, A. P. Journal of Controlled Release 2016, 221, 18. https://doi.org/10.1016/j.jconrel.2015.11.023
  6. Mohamed, S. M. E.; Elbadawy, A. K.; Mamdouh, A. S.; Smaher, M. E. Arabian Journal of Chemistry 2015, 8, 355. https://doi.org/10.1016/j.arabjc.2014.01.007
  7. Yu, C. Y.; Ling, Y. D.; Kai, D.; Wei, X.; Yan, Y.; Lu, Z.; Ke, W.; Feng, J. X. Carbohydrate Polymers 2015, 130, 243. https://doi.org/10.1016/j.carbpol.2015.03.075
  8. Nannan, G.; Shaoyu, L.; Chunmei, G.; Xinggang, W.; Xiubin, X.; Xiao, B.; Chen, F.; Mingzhu, L. Chemical Engineering Journal 2016, 287, 20. https://doi.org/10.1016/j.cej.2015.11.015
  9. Dong, M.; Jiantao, L.; Yuyun, C.; Wei, X.; Li, M. Z. Carbon 2012, 50, 3001. https://doi.org/10.1016/j.carbon.2012.02.083
  10. Mara, G.; Priscilla, F.; Dina, M.; João, R.; Xue, Q.; Changsheng, L.; Helena, T.; Yulin, L. Acta Biomaterialia 2014, 10, 300. https://doi.org/10.1016/j.actbio.2013.09.013
  11. Cho, E. J.; Sun, B.; Doh, K. O.; Wilson, E. M.; Torregrosa-Allen, S.; Elzey, B. D.; Yeo, Y. Biomaterial 2015, 37, 312. https://doi.org/10.1016/j.biomaterials.2014.10.039
  12. Kraemer, J.; Ludwig, J.; Bickert, U.; Owczarek, V.; Traupe, M. Ideas And Technical Innovations 1997, 6, 357.
  13. Lofthouse, S.; Nagahara, S.; Sedgmen, B.; Barcham, G.; Brandon, M.; Sano, A. Vaccine 2001, 19, 4318. https://doi.org/10.1016/S0264-410X(01)00153-0
  14. Hicks, B. G.; Lopez, E. A.; Eastman Jr., R.; Simonovsky, F. I.; Ratner, B. D.; Wessells, H.; Voelzke, B. B.; Bassuk, J. A. Biomaterials 2011, 32, 797. https://doi.org/10.1016/j.biomaterials.2010.09.050
  15. Xanthippi, C.; Rameshwar, R. R.; David, J. C.; Alexis, W. P.; Blake, M. A.; Yuan, Y. W.; Li, Z.; Fenno, J. C. F.; Jan, P. S.; Petros, P. Journal of Non-Crystalline Solids 2016, 432, 143. https://doi.org/10.1016/j.jnoncrysol.2015.03.024
  16. Tsai, M. C.; Hung, K. C.; Hung, S. C.; Hsu, S. Colloids and Surfaces B: Biointerfaces 2015, 125, 34. https://doi.org/10.1016/j.colsurfb.2014.11.003
  17. Pourjavadi, A.; Ayyari, M.; Amini-Fazl, M. S. European Polymer Journal 2008, 44, 1209. https://doi.org/10.1016/j.eurpolymj.2008.01.032
  18. Isabelle, B.; Marek, K.; Sylvie, R.; Bhuvanesh, G.; Jons, H.; Florian, W.; Peter, F. Biomaterials 2002, 23, 3149. https://doi.org/10.1016/S0142-9612(02)00061-3
  19. Pinto, V. C.; Ramos, T.; Alves, S.; Xavier, J.; Tavares, P.; Moreira, P. M. G. P.; Guedesa, R. M. Procedia Engineering 2015, 114, 635. https://doi.org/10.1016/j.proeng.2015.08.004
  20. Yoon, I. K.; Hwang, J. Y.; Seo, J. W.; Jang, W. C.; Kim, H. W.; Shin, U. S. Carbon 2014, 77, 379. https://doi.org/10.1016/j.carbon.2014.05.041