Blood Aluminum Concentrations among Residents of the South-east Costal Area of Korea

우리나라 일부 지역 주민들의 혈중 알루미늄 농도

Seo, Jeong-Wook;Kim, Byoung-Gwon;Kim, Yu-mi;Chung, Jin-Yong;Lim, Hyoun-Ju;Ye, Byeong-Jin;Hong, Young-Seoub

  • Received : 2016.03.10
  • Accepted : 2016.06.14
  • Published : 2016.06.30


Objectives: Aluminum is well known as a potent neurotoxicant. There are many reports that aluminum can be toxic to humans and to animals. However, there are only few studies on the assessment of aluminum exposure among humans in Korea. Therefore, the aim of this study was to evaluate current aluminum concentrations among the adult population in regions of Korea. Methods: We selected 439 adults aged 20-89 years from the Busan-Ulsan-Gyeongnam region and certain other sites. Blood aluminum concentrations were analyzed using inductively-coupled plasma mass spectrometry (ICP/MS). The geometric means (GM) and 95% confidence intervals (CI) of aluminum concentrations were calculated, and we also confirmed the proportion of excess of the aluminum reference value. Results: Total GM (95% CI) of aluminum levels was 14.26 (13.43-15.14) ppb. Levels among males (15.58 [14.09-17.22] ppb) were higher compared to among females (13.51 [12.54-14.55] ppb), and levels increased with subject age from 40 years and over. Three point one nine percent of the subjects exceed the reference value of 50 ppb. Lastly, aluminum concentration has a log-normal distribution with lnN (x; 2.89, 0.642), x>0. Conclusion: In the present study, we evaluated the distribution of blood aluminum concentrations among the normal population in Korea, and we found some adults exceeding the reference levels. However, in order to compare the results with other studies, an extended study including measurement of serum aluminum level is required. In addition, further research on various population groups, including occupational exposure of workers, is required.


Blood aluminum;normal population


  1. Harbison RD, Bourgeois MM, Johnson GT. Hamilton and Hardy's industrial toxicology: John Wiley & Sons; 2015.
  2. Monteagudo F, Cassidy M, Folb P. Recent developments in aluminium toxicology. Med Toxicol Adverse Drug Exp. 1989; 4(1): 1-16.
  3. Sprague SM, Corwin HL, Wilson RS, Mayor GH, Tanner CM. Encephalopathy in chronic renal failure responsive to deferoxamine therapy: Another manifestation of aluminum neurotoxicity. Arch Intern Med. 1986; 146(10): 2063-2064.
  4. Bast-Pettersen R, Skaug V, Ellingsen D, Thomassen Y. Neurobehavioral performance in aluminum welders. Am J Ind Med. 2000; 37(2): 184-192.<184::AID-AJIM4>3.0.CO;2-O
  5. Buchtaa M, Kiesswetterb E, Schaperb M, Zschieschec W, Schallerd K, Kuhlmanna A, et al. Neurotoxicity of exposures to aluminium welding fumes in the truck trailer construction industry. Environ Toxicol Pharmacol. 2005; 19(3): 677-685.
  6. Iregren A, Sjogren B, Gustafsson K, Hagman M, Nylen L, Frech W, et al. Effects on the nervous system in different groups of workers exposed to aluminium. Occup Environ Med. 2001; 58(7): 453-460.
  7. Riihimaki V, Hanninen H, Akila R, Kovala T, Kuosma E, Paakkulainen H, et al. Body burden of aluminum in relation to central nervous system function among metal inert-gas welders. Scand J Work Environ Health. 2000: 118-130.
  8. Colomina MT, Roig JL, Torrente M, Vicens P, Domingo JL. Concurrent exposure to aluminum and stress during pregnancy in rats: Effects on postnatal development and behavior of the offspring. Neurotoxicol Teratol. 2005; 27(4): 565-574.
  9. Donald JM, Golub MS, Gershwin ME, Keen CL. Neurobehavioral effects in offspring of mice given excess aluminum in diet during gestation and lactation. Neurotoxicol Teratol. 1989; 11(4): 345-351.
  10. Golub MS, Germann SL. Long-term consequences of developmental exposure to aluminum in a suboptimal diet for growth and behavior of Swiss Webster mice. Neurotoxicol Teratol. 2001; 23(4): 365-372.
  11. Oteiza PI, Keen CL, Han B, Golub MS. Aluminum accumulation and neurotoxicity in Swiss-Webster mice after long-term dietary exposure to aluminum and citrate. Metabolism. 1993; 42(10): 1296-1300.
  12. Baxter PJ, Aw T-C, Cockcroft A, Durrington P, Harrington JM. Hunter's diseases of occupations: CRC Press; 2010.
  13. Bingham E, Cohrssen B, Powell CH. Patty's toxicology. Volume 2: toxicological issues related to metals, neurotoxicology and radiation metals and metal compounds: John Wiley and Sons; 2001.
  14. Agius R. Patty’s Industrial Hygiene. Occup Med. 2012; 62(1): 69-70.
  15. ATSDR. Toxicological profile for aluminum. 2008.
  16. EFSA. Safety of aluminium from dietary intake-Scientific opinion of the panel on food additives, flavourings, processing aids and food contact materials (AFC). 2008.
  17. Gruskin A. Aluminum: a pediatric overview. Adv Pediatr. 1988; 35: 281-330.
  18. Domingo JL. Reproductive and developmental toxicity of aluminum: a review. Neurotoxicol Teratol. 1995; 17(4): 515-521.
  19. Rao KSJ, Rao BS, Vishnuvardhan D, Prasad KV. Alteration of superhelical state of DNA by aluminium (Al). Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression. 1993; 1172(1): 17-20.
  20. IARC. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Supplement 6, Genetic and Related Effects: An Updating of Selected IARC Monographs from Volume 1 to 42. Lyon. 1987: 57-59.
  21. MFDS. The annual report of Korea food & drug administratoin: TDI evaluation of aluminum. 2007:402.
  22. MFDS. Dietary Intake and Risk Assessment of Contaminants in Korean Foods. 2009.
  23. Roberts N, Zhu H, Kim J, Shin H, Kim J, Choi S. Further studies on the interrelationship of aluminum and silicon in patients receiving aluminum hydroxide therapy for dyspepsia and factors that relate to the solubilization of aluminum. The Journal of Trace Elements in Experimental Medicine. 2002; 15(1): 9-19.
  24. Kim JY, Shin HR, Kim JI, Kim DH, Choi SR, Seoh JI, et al. Effect on Aluminum and Silicon in Peptic Ulcer Patients. Korean Journal of Preventive Medicine. 1999; 32(2): 200-205.
  25. Kim JM, Ahn JM, Kim WS, Kim JI, Shin HR, Jung KY, et al. Blood lead, MAnganese, aluminium and silicon concentrations in korean adults. Korean Journal of Preventive Medicine. 2000; 33(2): 157-164.
  26. Jung EI, Song KH. A Study of Anthropometric Characteristics, Serum Lipids and Serum Aluminium Levels in College Students. Korean Living Science Association: workshop presentation file. 2009;2009(0): 123-124.
  27. Sorenson JR, Campbell IR, Tepper LB, Lingg RD. Aluminum in the environment and human health. Environ Health Perspect. 1974; 8: 3.
  28. Schultze B, Lind PM, Larsson A, Lind L. Whole blood and serum concentrations of metals in a Swedish population-based sample. Scand J Clin Lab Invest. 2014; 74(2): 143-148.
  29. House RA. Factors affecting plasma aluminum concentrations in nonexposed workers. J Occup Environ Med. 1992; 34(10): 1013-1017.
  30. Drablos P, Hetland S, Schmidt F, editors. Uptake and excretion of aluminum in workers exposed to aluminum fluoride and aluminum oxide. Proceedings of the second international conference on aluminum and health, Tampa, Fl; 1992.
  31. Nieboer E, Gibson BL, Oxman AD, Kramer JR. Health effects of aluminum: a critical review with emphasis on aluminum in drinking water. Environmental Reviews. 1995; 3(1): 29-81.
  32. JECFA. Summary and conclusions of the sixty-seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). 2006.
  33. EPA. Health Hazard Assessments for Effects Other than Cancer: Aluminum phosphide Reference Dose for Oral Exposure. 2008.
  34. Yokel RA, Golub MS. Research issues in aluminium toxicity: Taylor & Francis; 1997.
  35. GCLabs. Test Information, reference value. 2016.
  36. Quest Diagnostics Test aluminum, reference rage.
  37. Axelsson M, Rodushkin I. Multi-element analysis of body fluids by double-focusing ICP-MS. Transworld Res Network Recent Res Devel Pure & Applied Chem. 2001; 5: 51-66.
  38. Rodushkin I, Odman F, Branth S. Multielement analysis of whole blood by high resolution inductively coupled plasma mass spectrometry. Fresenius J Anal Chem. 1999; 364(4): 338-346.


Supported by : Ministry of Environment