해파리 콜라겐 추출물의 보습 효과

DOI QR코드

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김동욱;백태선;김윤정;최성규;이대우
Kim, Dong Wook;Baek, Tae Seon;Kim, Yun Jeong;Choi, Sung Kyu;Lee, Dae Woo

  • 투고 : 2016.02.04
  • 심사 : 2016.05.27
  • 발행 : 2016.06.30

초록

본 연구에서는 해파리로부터 콜라겐 추출물을 제조하였고, 이에 대한 보습 효과를 측정하였다. 보습 효과는 caspase 14 발현, filaggrin, hyaluronan synthase-3 (HAS- 3), aquaporin-3 (AQP-3) 및 desmocollin (DSC)을 측정하였다. 그 결과, caspase 14 mRNA 발현은 비교물질인 retinoic acid (RA)와 유사한 효과를 나타냈다. 그리고 콜라겐 추출물은 20 mg/mL의 농도에서 각각 211.7%, 139.9%, 212.5% 및 116.8%의 filaggrin, HAS-3, AQP-3 및 DSC 발현 증가를 나타냈다. 따라서, 본 연구에서 해파리 콜라겐 추출물은 보습 효과를 갖는 화장품 소재로서의 개발 가능성이 클 것으로 기대할 수 있다.

키워드

Nemopilema nomurai;collagen;moisturizing;jellyfish;cosmetics

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