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Evaluation of Dose Enhancement by Gold Nanoparticles using Mathematical Head Phantom

금 나노입자를 활용한 두부 모의피폭체에서의 선량증가 효과 평가

  • 황철환 (부산대학교병원 방사선종양학과) ;
  • 박은태 (인제대학교 부산백병원 방사선종양학과) ;
  • 김정훈 (부산가톨릭대학교 보건과학대학 방사선학과)
  • Received : 2016.03.30
  • Accepted : 2016.05.09
  • Published : 2016.08.28

Abstract

The effect of dose enhancement was evaluated using Snyder head phantom, dependence on size of gold nanoparticle and material concentration in megavoltage X, ${\gamma}$-ray. Monte Carlo simulation using MCNPX was used for 4, 6, 10, 15 MV and Co-60 ${\gamma}$-ray. Described the tumor in Snyder head phantom, gold nanoparticle of 25, 75, 125nm diameter was inserted inside tumor. Concentration of dose enhancement material was used for 5, 15, 25 mg/g and dose enhancement factor was calculated on the basis of the no dose enhancement material. The lower incident energy and the higher concentration of material were that high dose enhancement factor is indicated. The size of gold nanoparticle had relatively high dependence on lower incident energy and higher concentration of material. It will increase dose inside the tumor, and be additional effect of use of gold nanoparticles in radiation therapy.

Keywords

Gold Nanoparticle;Dose Enhancement;Monte Carlo;Head Phantom

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