Simultaneous analysis of β-lactam antibiotics and β-blockers by LC-MS/MS

LC-MS/MS를 이용한 베타락탐계 항생제와 베타차단제의 동시분석

  • Received : 2016.04.27
  • Accepted : 2016.08.24
  • Published : 2016.08.25


An effective analytical method has been developed for the determination of β-blockers(atenolol, metoprolol and propranolol) and 6 β-lactams(amoxicillin, penicillin G, cefaclor, cefadroxil, cephalexin and cephradine) in water samples using two different cartridges. The samples were extracted by solid-phase extraction (SPE) with the usage of polymeric hydrophile-lipophile balance(HLB cartridges) and strong cation-exchange mixed-mode polymeric sorbent (MCX cartridges). A XDB-C18 column(1.8 μm; 3.0 mm × 100 mm) was used for the sufficient chromatographic resolution. The calibration curves showed good linearity with high correlation coefficients (>0.995). The method detection limits (MDL) and the limits of quantification(LOQ) were from 1.1 to 3.9 ng/L and from 5 to 13 ng/L, respectively. The method was applied for the determination of the target compounds in tributaries and raw water of the Han River and these were found at N.D. to 0.209 μg/L.


β-blockers;β-lactams antibiotics;SPE;LC-MS/MS


Grant : 신종 오염물질 분석 및 데이터베이스 구축

Supported by : 서울물연구원


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