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Changes in bispectral index score and cardiorespiratory function under constant rate infusion with alfaxalone in dogs

  • Yun, Sungho (Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Kwon, Young-Sam (Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University)
  • Received : 2016.02.24
  • Accepted : 2016.06.20
  • Published : 2016.09.30

Abstract

Changes in the cardiovascular and bispectral index score were evaluated in dogs subjected to constant rate infusion (CRI) with alfaxalone. Fifteen dogs were assigned to three groups of 5. Groups and doses of alfaxalone were as follows: group 1, 3 mg/kg for induction and 6 mg/kg/h for CRI; group 2, 3 mg/kg for induction and 8 mg/kg/h for CRI; and group 3, 3 mg/kg for induction and 10 mg/kg/h for CRI. CRI was maintained for 1 h. Respiratory rates and blood pressures showed minimal changes; however, mild tachycardia and mild hypoxemia occurred, especially in group 3. There were some disparities between bispectral index score, electromyography and pedal withdrawal reflex test when measuring anesthetic depth. Additional premedications and/or analgesic agents would be helpful to avoid adverse effects of alfaxalone and provide improved cardiopulmonary functions.

References

  1. Amengual M, Flaherty D, Auckburally A, Bell AM, Scott EM, Pawson P. An evaluation of anaesthetic induction in healthy dogs using rapid intravenous injection of propofol or alfaxalone. Vet Anaesth Analg 2012, 40, 115-123.
  2. Bleijenberg EH, van Oostrom H, Akkerdaas LC, Doornenbal A, Hellebrekers LJ. Bispectral index and the clinically evaluated anaesthetic depth in dogs. Vet Anaesth Analg 2011, 38, 536-543. https://doi.org/10.1111/j.1467-2995.2011.00651.x
  3. Child KJ, Currie JP, Dis B, Dodds MG, Pearce DR, Twissell DJ. The pharmacological properties in animals of CT1341-a new steroid anaesthetic agent. Br J Anaesth 1971, 43, 2-13.
  4. Dodman NH. Complications of saffan anaesthesia in cats. Vet Rec 1980, 107, 481-483. https://doi.org/10.1136/vr.107.21.481
  5. Eyres R. Update on TIVA. Paediatr Anaesth 2004, 14, 374-379. https://doi.org/10.1111/j.1460-9592.2004.01333.x
  6. Ferre PJ, Pasloske K, Whittem T, Ranasinghe MG, Li Q, Lefebvre HP. Plasma pharmacokinetics of alfaxalone in dogs after an intravenous bolus of Alfaxan-CD RTU. Vet Anaesth Analg 2006, 33, 229-236. https://doi.org/10.1111/j.1467-2995.2005.00264.x
  7. Johansen JW. Update on bispectral index monitoring. Best Pract Res Clin Anaesthesiol 2006, 20, 81-99.
  8. Keates H, Whittem T. Effect of intravenous dose escalation with alfaxalone and propofol on occurrence of apnoea in the dog. Res Vet Sci 2012, 93, 904-906. https://doi.org/10.1016/j.rvsc.2011.10.003
  9. Mathis A, Pinelas R, Brodbelt DC, Alibhai HIK. Comparison of quality of recovery from anaesthesia in cats induced with propofol or alfaxalone. Vet Anaesth Analg 2012, 39, 282-290. https://doi.org/10.1111/j.1467-2995.2011.00707.x
  10. Morton NS. Total intravenous anaesthesia (TIVA) in paediatrics: advantages and disadvantages. Paediatr Anaesth 1998, 8, 189-194. https://doi.org/10.1046/j.1460-9592.1998.00759.x
  11. Muir W, Lerche P, Wiese A, Nelson L, Pasloske K, Whittem T. The cardiorespiratory and anesthetic effects of clinical and supraclinical doses of alfaxalone in cats. Vet Anaesth Analg 2009, 36, 42-54. https://doi.org/10.1111/j.1467-2995.2008.00428.x
  12. Muir W, Lerche P, Wiese A, Nelson L, Pasloske K, Whittem T. Cardiorespiratory and anesthetic effects of clinical and supraclinical doses of alfaxalone in dogs. Vet Anaesth Analg 2008, 35, 451-462. https://doi.org/10.1111/j.1467-2995.2008.00406.x
  13. Psatha E, Alibhai HI, Jimenez-Lozano A, Armitage-Chan E, Brodbelt DC. Clinical efficacy and cardiorespiratory effects of alfaxalone, or diazepam/fentanyl for induction of anaesthesia in dogs that are a poor anaesthetic risk. Vet Anaesth Analg 2011, 38, 24-36. https://doi.org/10.1111/j.1467-2995.2010.00577.x
  14. Robertson SA. Total intravenous anaesthesia (TIVA) in the horse. Equine Vet Educ 1997, 9, 17-20. https://doi.org/10.1111/j.2042-3292.1997.tb01269.x
  15. Smith NR. Complications of Saffan anaesthesia in cats. Vet Rec 1981, 108, 220. https://doi.org/10.1136/vr.108.10.220
  16. Stogdale L. Laryngeal oedema due to Saffan in a cat. Vet Rec 1978, 102, 283-284. https://doi.org/10.1136/vr.102.13.283
  17. Suarez MA, Dzikiti BT, Stegmann FG, Hartman M. Comparison of alfaxalone and propofol administered as total intravenous anaesthesia for ovariohysterectomy in dogs. Vet Anaesth Analg 2012, 39, 236-244. https://doi.org/10.1111/j.1467-2995.2011.00700.x
  18. Tsai YC, Wang LY, Yeh LS. Clinical comparison of recovery from total intravenous anesthesia with propofol and inhalation anesthesia with isoflurane in dogs. J Vet Med Sci 2007, 69, 1179-1182. https://doi.org/10.1292/jvms.69.1179
  19. Watt JM. Anaphylactic reactions after use of CT 1341 (althesin). Br Med J 1975, 3, 205-206.
  20. Whittem T, Pasloske KS, Heit MC, Ranasinghe MG. The pharmacokinetics and pharmacodynamics of alfaxalone in cats after single and multiple intravenous administration of Alfaxan at clinical and supraclinical doses. J Vet Pharmacol Ther 2008, 31, 571-579. https://doi.org/10.1111/j.1365-2885.2008.00998.x