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Prognostic factors and efficacy of human intravenous immunoglobulin G in dogs with idiopathic immune-mediated hemolytic anemia: a retrospective study

  • Park, So-Young (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Kim, Hakhyun (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Kang, Byeong-Taek (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Kang, Ji-Houn (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University) ;
  • Yang, Mhan-Pyo (College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University)
  • Received : 2016.03.18
  • Accepted : 2016.06.24
  • Published : 2016.09.30

Abstract

This study was conducted to determine the effect of treatment with intravenous human immunoglobulin G (hIVIgG) on outcome in dogs with idiopathic immune-mediated hemolytic anemia (IMHA), and to identify prognostic variables that determine outcome in affected dogs. Thirty-seven dogs that met the inclusion criteria were enrolled in a retrospective study. The dogs were categorized into two groups based on their having received hIVIgG. There was no significant difference in survival between the hIVIgG group and the non-hIVIgG group. Mortality during hospitalization and at 1 month, 1 year, or 2 years after discharge was not significantly different between the hIVIgG and the non-hIVIgG groups. Hemoglobinuria was significantly less prevalent in dogs that lived more than 1 year than in those who lived less than 1 year, and was less prevalent in dogs that lived more than 2 years than in those who lived less than 2 years. However, there was no difference in the presence of hemoglobinuria between dogs that lived less than 1 month and those that lived more than 1 month. Overall, there was no evidence of a beneficial effect of hIVIgG in dogs with idiopathic IMHA.

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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