Fermented antler extract enhances the viability and interleukin-12 production of spleen cells

발효녹용 추출물에 의한 비장세포의 생존율 및 interleukin-12 생산 증진

  • Yang, Hye-Yeoul (Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University) ;
  • Kim, Youngsu (Malgeunsaem Korean Medicine Clinic) ;
  • Joo, Hong-Gu (Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University)
  • 양혜열 (제주대학교 수의과대학 수의약리학실) ;
  • 김영수 (맑은샘한의원) ;
  • 주홍구 (제주대학교 수의과대학 수의약리학실)
  • Received : 2016.02.02
  • Accepted : 2016.06.25
  • Published : 2016.09.30


The effects of antlers have long been known in traditional Asian medicine. However, few studies have investigated the effects of antlers on immunity. In this study, we investigated whether fermented antler extract (FAE) has immunomodulatory effects on spleen cells. FAE enhanced the activity of spleen cells in a concentration dependent manner compared to antler extract. Interestingly, FAE significantly increased the production of interleukin-12, a representative cytokine of cell-mediated immunity, while it marginally increased that of tumor necrosis factor-alpha. Flow cytometry analysis demonstrated that FAE can protect spleen cells from spontaneous cell death without a significant proportional change in subsets, mainly lymphocytes. Taken together, the results of the present study showed that FAE has beneficial effects on spleen cells, a major type of immune cell, indicating that it can function as an immunomodulator without significant cytotoxicity. These data may broaden the use of FAE in basic research and clinical areas.


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