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Adverse Drug Reactions of Dextran 40 Treated to the Cerebral Infarction Patients

뇌경색 환자에게 사용된 덱스트란 40의 부작용 분석

  • 김재현 (전주비전대학교 간호학부/전주예수병원 의약품부작용위원회)
  • Received : 2016.05.12
  • Accepted : 2016.07.15
  • Published : 2016.09.28

Abstract

Adverse drug reactions(ADRs) were caused by dexran 40 in patient with ischemic stroke and related 22 patients reported to formal ADRs at Jesus Hospital in Jeonju. This study was aimed to search ADRs related factors, type and the degree associated with dextran 40. Adverse Effects of Dextran 40 is including marked hypotension, nausea, dyspnea, generalized urticaria, fever and pulmonary edema. The average hospitalization period was 20 days and it was extended 26.8%. ADRs of Dextran 40 to incidence is 12.4%, and 9 persons(28.1%), itching, rash was 7 people (21.9%). Dextran induced ADRs reaction may be reported on early injection period and first time shot, but adverse drug reactions occurred after 4 days in 4 patients(18.2%). US FDA has recommanded that Dextran 1 significantly reduces the incidence of severe ADRs in USA. Because low molecular weighted dextran 1 prevented dextran molecules from combined Ig G completely. In Korea. Generally not yet introduced dextran 1, active use dextran 1 is able to be a good way in order to reduce ADRs of dextran 40.

Keywords

Adverse Drug Reaction;Dextran;Cerebral Infarction

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