DOI QR코드

DOI QR Code

Prestrain-induced Reduction in Skin Tissue Puncture Force of Microneedle

초기변형률에 의한 미소바늘의 피부조직 관통력 감소

  • 김종훈 (인하대학교 기계공학과) ;
  • 박성민 (인하대학교 기계공학과) ;
  • 남경목 (인하대학교 기계공학과) ;
  • 윤상희 (인하대학교 기계공학과)
  • Received : 2016.03.04
  • Accepted : 2016.08.08
  • Published : 2016.10.01

Abstract

Despite all the recent advances in biodegradable material-based microneedles, the bending and failure (especially buckling) of a biodegradable microneedle during skin tissue insertion remains a major technical hurdle for its large-scale commercialization. A reduction in skin tissue puncture force during microneedle insertion remains an essential issue in successfully developing a biodegradable microneedle. Here, we consider uniaxial and equibiaxial prestrains applied to a skin tissue as mechanophysical stimuli that can reduce the skin tissue puncture force, and investigate the effect of prestrain on the changes in skin tissue puncture force. For a porcine skin tissue similar to that of humans, the skin tissue puncture force of a flat-end microneedle is measured with a z-axis stage equipped with a load cell, which provides a force-time curve during microneedle insertion. The findings of this study lead to a quantitative characterization of the relationship between prestrain and the skin tissue puncture force.

Keywords

Skin Tissue;Microneedle;Insertion;Prestrain;Puncture Force

Acknowledgement

Supported by : 한국연구재단

References

  1. Abolhassani, N., Patel, R. and Moallem, M., 2007, "Needle Insertion into Soft Tissue," Med. Eng. Phys., Vol. 29, No. 4, pp. 413-431. https://doi.org/10.1016/j.medengphy.2006.07.003
  2. Park, J. H., Allen, M. K. and Prausnitz, M. R., 2005, "Biodegradable Polymer Microneedles: Fabrication, Mechanics and Transdermal Drug Delivery," J. Control. Release, Vol. 104, No. 1, pp. 51-66. https://doi.org/10.1016/j.jconrel.2005.02.002
  3. Davis, S. P., Landis, B. J., Adams, Z. H., Allen, M. G. and Prausnitz, M. R., 2004, "Insertion of Microneedles into Skin: Measurement and Prediction of Insertion Force and Needle Fracture Force," J. Biomech., Vol. 37, No. 8, pp. 1155-1163. https://doi.org/10.1016/j.jbiomech.2003.12.010
  4. Simone, C. and O'Leary, D. M., 2004, "Force Modeling for Needle Insertion into Soft Tissue," IEEE Trans. Biomed. Eng., Vol. 51, No. 10, pp. 1707-1716. https://doi.org/10.1109/TBME.2004.831542
  5. Mahvash, M. and Dupont, E. P., 2009, "Fast Needle Insertion to Minimize Tissue Deformation and Damage," In Proceeding of IEEE International Conference on Robotics and Automation, Kobe, Japan, 12-17 May.
  6. Mahvash, M. and Dupont, P. E., 2010, "Mechanics of Dynamic Needle Insertion into a Biological Material," IEEE Trans. Biomed. Eng., Vol. 57, No. 4, pp. 934-943. https://doi.org/10.1109/TBME.2009.2036856