Prestrain-induced Reduction in Skin Tissue Puncture Force of Microneedle

초기변형률에 의한 미소바늘의 피부조직 관통력 감소

  • 김종훈 (인하대학교 기계공학과) ;
  • 박성민 (인하대학교 기계공학과) ;
  • 남경목 (인하대학교 기계공학과) ;
  • 윤상희 (인하대학교 기계공학과)
  • Received : 2016.03.04
  • Accepted : 2016.08.08
  • Published : 2016.10.01


Despite all the recent advances in biodegradable material-based microneedles, the bending and failure (especially buckling) of a biodegradable microneedle during skin tissue insertion remains a major technical hurdle for its large-scale commercialization. A reduction in skin tissue puncture force during microneedle insertion remains an essential issue in successfully developing a biodegradable microneedle. Here, we consider uniaxial and equibiaxial prestrains applied to a skin tissue as mechanophysical stimuli that can reduce the skin tissue puncture force, and investigate the effect of prestrain on the changes in skin tissue puncture force. For a porcine skin tissue similar to that of humans, the skin tissue puncture force of a flat-end microneedle is measured with a z-axis stage equipped with a load cell, which provides a force-time curve during microneedle insertion. The findings of this study lead to a quantitative characterization of the relationship between prestrain and the skin tissue puncture force.


Skin Tissue;Microneedle;Insertion;Prestrain;Puncture Force


Supported by : 한국연구재단


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