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Fabrication of BCP/Silica Scaffolds with Dual-Pore by Combining Fused Deposition Modeling and the Particle Leaching Method

압출 적층 조형법과 입자 추출법을 결합한 이중 공극 BCP/Silica 인공지지체의 제작

  • Sa, Min-Woo (Dept. of Mechanical Engineering, Andong Nat'l Univ.) ;
  • Kim, Jong Young (Dept. of Mechanical Engineering, Andong Nat'l Univ.)
  • 사민우 (안동대학교 기계공학과) ;
  • 김종영 (안동대학교 기계공학과)
  • Received : 2016.04.22
  • Accepted : 2016.07.11
  • Published : 2016.10.01

Abstract

In recent years, traditional scaffold fabrication techniques such as gas foaming, salt leaching, sponge replica, and freeze casting in tissue engineering have significantly limited sufficient mechanical property and cell interaction effect due to only random pores. Fused deposition modeling is the most apposite technology for fabricating the 3D scaffolds using the polymeric materials in tissue engineering application. In this study, 3D slurry mould was fabricated with a blended biphasic calcium phosphate (BCP)/Silica/Alginic acid sodium salt slurry in PCL mould and heated for two hours at $100^{\circ}C$ to harden the blended slurry. 3D dual-pore BCP/Silica scaffold, composed of macro pores interconnected with micro pores, was successfully fabricated by sintering at furnace of $1100^{\circ}C$. Surface morphology and 3D shape of dual-pore BCP/Silica scaffold from scanning electron microscopy were observed. Also, the mechanical properties of 3D BCP/Silica scaffold, according to blending ratio of alginic acid sodium salt, were evaluated through compression test.

Keywords

Fused Deposition Modeling;Particle Leaching;Scaffold;Biphasic Calcium Phosphate;Silica Particles

Acknowledgement

Supported by : 안동대학교

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