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Detection of Streptavidin-Biotin Complexes Using a Highly Sensitive AlGaN/GaN-Based Extended-Gate MISHEMT-Type Biosensor

  • Lee, Hee Ho (School of Electronics Engineering, Kyungpook National Unversity) ;
  • Bae, Myunghan (School of Electronics Engineering, Kyungpook National Unversity) ;
  • Choi, Byoung-Soo (School of Electronics Engineering, Kyungpook National Unversity) ;
  • Shin, Jang-Kyoo (School of Electronics Engineering, Kyungpook National Unversity)
  • Received : 2016.09.07
  • Accepted : 2016.09.30
  • Published : 2016.09.30

Abstract

In this paper, we propose an AlGaN/GaN-based extended-gate metal-insulator-semiconductor high electron mobility transistor (MISHEMT)-type biosensor for detecting streptavidin-biotin complexes. We measure the drain current of the fabricated sensor, which varies depending on the antibody-antigen reaction of streptavidin with biotin molecules. To confirm the immobilization of biotin polyethylene glycol (PEG) thiol, we analyze the Au surface of a GaN sample using X-ray photoelectron spectroscopy (XPS). The proposed biosensor shows higher sensitivity than Si-based extended-gate metal oxide semiconductor field effect transistor (MOSFET)-type biosensor. In addition, the proposed AlGaN/GaN-based extended-gate MISHEMT-type biosensor exhibits better long-term stability, compared to the conventional AlGaN/GaN-based MISHEMT-type biosensor.

Acknowledgement

Supported by : Ministry of Education

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