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Establishment for analytical method of methanol in wet wipes by headspace gas chromatography

가스크로마토그래프-헤드스페이스를 이용한 물휴지 중 메탄올 정량법 확립 연구

  • Choi, Yongkyu (Cosmetics Research Team, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Baek, Eunji (Cosmetics Research Team, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Min, Chungsik (Cosmetics Research Team, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Lee, Rheeda (Cosmetics Research Team, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Park, Soonyoung (Cosmetics Research Team, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Ahn, Jaehyung (Cosmetics Research Team, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Kim, Sangseop (Cosmetics Research Team, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Hong, Seonghwa (Cosmetics Research Team, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex) ;
  • Kim, Younglim (Cosmetics Research Team, National Institute of Food and Drug Safety Evaluation, Osong Health Technology Administration Complex)
  • 최용규 (식품의약품안전평가원 화장품연구팀) ;
  • 백은지 (식품의약품안전평가원 화장품연구팀) ;
  • 민충식 (식품의약품안전평가원 화장품연구팀) ;
  • 이이다 (식품의약품안전평가원 화장품연구팀) ;
  • 박순영 (식품의약품안전평가원 화장품연구팀) ;
  • 안재형 (식품의약품안전평가원 화장품연구팀) ;
  • 김상섭 (식품의약품안전평가원 화장품연구팀) ;
  • 홍성화 (식품의약품안전평가원 화장품연구팀) ;
  • 김영림 (식품의약품안전평가원 화장품연구팀)
  • Received : 2016.05.02
  • Accepted : 2016.08.19
  • Published : 2016.10.25

Abstract

This research aims to set up and validate methods of analyzing the methanol in wet wipes and verifies the analysis methods that applied to the wet wipes. We used Headspace (HS) Gas Chromatography (GC) - Flame Ionization Detector (FID) to the establish analysis method of methanol in wet wipes and optimized heating temperature, heating time, GC conditions with column. The result indicated that 3 mL of sample in 20 mL headspace vial can be equilibrated efficiently in headspace sampler at 70 ℃ for 10 min and sample was measured by GC with spli injection mode(10:1). The results show that linearity from 1 to 100 ppm was over R2 0.9995, precision was RSD 1.83 % and accuracy(recovery rate) was 105.44 (±1.05 %) on water matrix and wet wipes matrix removed non-woven fabric. Also, monitoring results of total 20 cosmetics on the market, from 0.00017 to 0.00156 % of methanol was detected from wet wipes.

Keywords

cosmetic;methanol;wet wipes;headspace gas chromatography

References

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