Ashitaba and red ginseng complex stimulates exercise capacity by increasing mitochondrial biogenesis

미토콘드리아 생합성 촉진을 통한 신선초와 홍삼 복합물의 운동수행능력 증가 효과

  • 김창희 (연세대학교 생명공학과) ;
  • 김미보 (연세대학교 생명공학과) ;
  • 이승호 ((주)카인즈 바이오틱스 R&BD팀) ;
  • 김예진 ((주)카인즈 바이오틱스 R&BD팀) ;
  • 황재관 (연세대학교 생명공학과)
  • Received : 2017.07.21
  • Accepted : 2017.09.24
  • Published : 2017.12.31


Mitochondrial biogenesis-a process that leads to an increment in the number and density of mitochondria, improves physical performance and body health by enhancing exercise capacity. In the present study, we investigated the stimulatory effect of Ashitaba and red ginseng complex (ARC) on exercise capacity in L6 skeletal muscle cells and mice. In L6 skeletal muscle cells, ARC increased the mitochondrial contents and ATP production by activating AMP-activated protein kinase (AMPK), sirtuin 1 (SIRT1), and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-$1{\alpha}$) and up-regulating the mRNA expression of nuclear respiratory factor-1 (NRF-1) and mitochondrial transcription factor A (TFAM). In the animal experiments, mice treated with ARC showed an increment in exercise capacity as compared with mice treated with Ashitaba extract or red ginseng extract alone. These studies indicate that ARC might serve as a potential natural candidate for enhancing exercise capacity by stimulation of mitochondrial biogenesis.


Ashitaba;Exercise capacity;Mitochondrial biogenesis;Red ginseng


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