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Anti-inflammatory and anti-atopic effects of corn silk (Zea mays L.) ethanol extracts

옥수수수염 알코올 추출물의 항염 및 항아토피 효과

  • Kim, Hyun Young (Crop Foundation Division, National Institute of Crop Science, Rural Development Administration) ;
  • Lee, Mi-Ja (Crop Foundation Division, National Institute of Crop Science, Rural Development Administration) ;
  • Seo, Woo Duck (Crop Foundation Division, National Institute of Crop Science, Rural Development Administration) ;
  • Choi, Sik-Won (Crop Foundation Division, National Institute of Crop Science, Rural Development Administration) ;
  • Kim, Sun Lim (Department of Central Area Crop Science, National Institute of Crop Science, Rural Development Administration) ;
  • Jung, Gun-Ho (Department of Central Area Crop Science, National Institute of Crop Science, Rural Development Administration) ;
  • Kang, Hyeon Jung (Crop Foundation Division, National Institute of Crop Science, Rural Development Administration)
  • 김현영 (농촌진흥청 국립식량과학원 작물기초기반과) ;
  • 이미자 (농촌진흥청 국립식량과학원 작물기초기반과) ;
  • 서우덕 (농촌진흥청 국립식량과학원 작물기초기반과) ;
  • 최식원 (농촌진흥청 국립식량과학원 작물기초기반과) ;
  • 김선림 (농촌진흥청 국립식량과학원 중부작물부) ;
  • 정건호 (농촌진흥청 국립식량과학원 중부작물부) ;
  • 강현중 (농촌진흥청 국립식량과학원 작물기초기반과)
  • Received : 2017.07.14
  • Accepted : 2017.09.13
  • Published : 2017.12.31

Abstract

This study evaluates the ability of corn silk (Zea mays L.) extract to function as a natural anti-inflammatory and anti-atopic therapeutic agent. The anti-inflammatory effects of corn silk were evaluated by measuring the inhibitory activities of nitric oxide (NO) and production of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$. Anti-atopic effects were assessed by measuring the repression of thymus and activation-regulated chemokine (TARC). These results indicated that NICS-1 (corn silk ethanol extract) and NICS-3 (high maysin corn silk ethanol extract) functioned as anti-inflammatory agents by down-regulating LPS-induced NO and TNF-${\alpha}$. Additionally, two extracts showed weak repression of TARC expression levels in tumor necrosis factor TNF-${\alpha}$ plus IFN-${\gamma}$ induced HaCaT cells, respectively. These results suggest that corn silk extracts have anti-inflammatory and anti-atopic activities, and thus have the potential to reduce and alleviate the symptoms associated with atopic dermatitis.

Keywords

corn silk;anti-inflammatory;anti-atopic

Acknowledgement

Grant : 옥수수수염 함유 메이신 다량 분리법 개발 및 산업소재화를 위한 기초특성연구

Supported by : 농촌진흥청

References

  1. Cha SM, Son BY, Lee JS, Baek SB, Kim SL, Ku JH, Hwang JJ, Song BH, Woo SH, Kwon YU, Kim JT. Effect of particle size on physico-chemical properties and antioxidant activity of corn silk powder. Korean J. Crop Sci. 57: 41-50 (2012) https://doi.org/10.7740/kjcs.2012.57.1.041
  2. Ku KM, Kim SK, Kang YH. Antioxidant activity and functional components of corn silk (Zea mays L.). Korean J. Plant Res. 22: 323-329 (2009)
  3. Kim HY, Seo WD, Seo KH, Lee MJ, Choi SW, Lee KS, Kim SL, Kang HJ. Antioxidative and protective effects of corn silk (Zea mays L.) extract on human HaCaT keratinocyte. Korean J. Crop Sci. 61: 184-190 (2016) https://doi.org/10.7740/kjcs.2016.61.3.184
  4. Kim SL, Snook ME, Kim EH, Park CH. Identification of maysin and related flavonid analogues in corn silks. Korean J. Crop Sci. 45: 151-157 (2000)
  5. Lee SJ, Choi HR, Lee JC, Park HJ, Lee HK, Jeong JT, Lee TB. The Anti-aging effects of various berries in the Human skin keratinocyte (HaCaT) cells. Korean J. Food Sci. Technol. 46: 198-204 (2014) https://doi.org/10.9721/KJFST.2014.46.2.198
  6. Rang MJ. Anti-inflammatory and anti-allergic effects of herbal extracts on atopic dermatitis (Part I). J. Korean Oil Chem. Soc. 28: 75-84 (2011)
  7. Kwon OJ, Lee AR, Do KB. Anti-oxidant activities and antiatopic dermatitis effect of combined extract of Phellinus linteus and glycyrrhiza uralensis. Kor. J. Herbol. 32: 49-56 (2017)
  8. Yin HH, Cho BO, Lee HS, Chu JI, Jang SI. Synergistic effects of grape branch and pleurotus eryngii extract combination against inflammation on activated mast cells and atopic dermatitis-like skin lesions in mice. Korea J. Food Sci. Technol. 48: 582-589 (2016) https://doi.org/10.9721/KJFST.2016.48.6.582
  9. Kim KO, Ku CS, Kim MJ, Park YJ, Ryu HW. Song HH, Kim JH, Oh SR. Phytoecdysones from the roots of Achyranthes japonica Nakai and their anti-atopy activity. J. Appl. Biol. Chem. 58: 13-19 (2015) https://doi.org/10.3839/jabc.2015.004
  10. Choi MO, Kim BJ, Jo SK, Jung HK, Lee JT, Kim HY, Kweon DJ. Anti-allergic activities of castanea crenata inner shell extracts fermented by Lactobacillus bifermentans. Korean J. Food Preserv. 20: 583-591 (2013) https://doi.org/10.11002/kjfp.2013.20.4.583
  11. Kang BK, Kim KBWR, Kim M, Bark SW, Pak WM, Kim BR, Ahn NK, Choi YU, Ahn DH. Anti-inflammatory activity of an ethanol extract of Laminaria japonica root on lipopolysaccharide-induced inflammatory responses in RAW 264.7 cells. Korean J. Food Sci. Thehnol. 46: 729-733 (2014) https://doi.org/10.9721/KJFST.2014.46.6.729
  12. Kim NK. Kim MH. Yoon CS. Choi SW. Studies on the anti-inflammatory activity of paulownia coreana uyeki leaf extract. J. Soc. Cosmet. Sci. Korea 32: 241-247 (2006)
  13. Lee ST, Jeong YR, Ha MH, Kim SH, Byun MW, Jo SK. Induction of nitric oxide and TNF-${\alpha}$ by herbal plant extract in mouse macrophage. J. Korean Soc. Food Sci. Nutr. 29: 342-348 (2000)
  14. Choi Y, Kim MS, Hwang JK. Inhibitory effects of panduration a on allergy-related mediator production in rat basophilic leukemia mast cell. Inflammation 35: 1904-1915.(2012) https://doi.org/10.1007/s10753-012-9513-y
  15. Jin CH, Lee HJ, Park YD, Choi DS, Kim DS, Kang SY, Seo KI, Jeong IY. Isoegomaketone inhibits lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages through the heme oxygenase-1 induction and inhibition of the interferon-${\beta}$-STAT-1 pathway. J. Agr. Food Chem. 58: 860-867 (2010) https://doi.org/10.1021/jf9033333
  16. Kim I. Inhibitory Effects of Apple Peel Extract on Inflammatory Enzymes. Korea J. Food Sci. Technol. 47: 534-538 (2015) https://doi.org/10.9721/KJFST.2015.47.4.534
  17. Lee SY, Hyun JM, Kim SS, Park SM, Park KJ, Choi YH, Kim SH, Yu SN, Ahn SC. Anti-inflammatory Effect of Citrus unshiu Peels Fermented with Aspergillus niger. J. Life Sci. 24: 750-756 (2014) https://doi.org/10.5352/JLS.2014.24.7.750
  18. Kim YJ, Son DY. Antioxidant and inhibitory effects of korean Panax ginseng extract on pro-inflammatory mediators in LPS-induced RAW 264.7 macrophages. J. Korean Soc. Food Sci. Nutr. 41: 1371-1377 (2012) https://doi.org/10.3746/jkfn.2012.41.10.1371
  19. Moon JH, Go H, Shin SM, Kim KT. Anti-inflammatory effect of extracts from Ligustrum obtusifolium S. fruits in RAW 264.7 macrophages. J. Soc. Korean Med. Diagn. 17: 263-273 (2013)
  20. Giuliani C, Napolitano G, Bucci I, Montani V, Monaco F. NF-${\kappa}B$ transcription factor: role in the pathogenesis of inflammatory, autoimmune, and neoplastic diseases and therapy implications. Clin. Ter. 152: 249-253 (2001)
  21. Medzhitov R. Origin and physiological roles of inflammation. Nature 454: 428-435 (2008) https://doi.org/10.1038/nature07201
  22. Tak PP, Firestein GS. NF-${\kappa}B$: a key role in inflammatory diseases. J. Clin. Invest. 107: 7-11 (2001) https://doi.org/10.1172/JCI11830
  23. Kim HJ, Park TS, Jung MS, Son JH. Study on the anti-oxidant and anti-inflammatory activities of sarcocarp and calyx of persimmon (Cheongdo Bansi). J. Appl. Biol. Chem. 54: 71-78 (2011) https://doi.org/10.3839/jabc.2011.013
  24. Wang X, Luo Y, Liao WB, Zhang J, Chen TM. Effect of osteoprotegerin in combination with interleukin-6 on inhibition of osteoclast differentiation. Chin. J. Traumatol. 16: 277-280 (2013)