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Effect of Paecilomyces tenuipes extract on angiogenesis in prostate cancer cells

눈꽃동충하초 추출물이 전립선 암 세포 내 혈관신생인자 발현에 미치는 영향

  • Choi, Young-Jin (Division of Food Bioscience, Konkuk University) ;
  • Fan, Meiqi (Division of Food Bioscience, Konkuk University) ;
  • Choi, Eun-Ju (Department of Physical Education, Daegu Catholic University) ;
  • Kim, Eun-kyung (Division of Food Bioscience, Konkuk University)
  • 최영진 (건국대학교 식품생명과학부) ;
  • 범미기 (건국대학교 식품생명과학부) ;
  • 최은주 (대구가톨릭대학교 체육교육과) ;
  • 김은경 (건국대학교 식품생명과학부)
  • Received : 2017.12.18
  • Accepted : 2017.12.22
  • Published : 2017.12.31

Abstract

In this study, the inhibitory effect of Paecilomyces tenuipes extract on PSA and angiogenesis-related factor expression levels were investigated in human prostate cancer cells, LNCaP. P. tenuipes extract significantly inhibited PSA expression in a dose-dependent manner. We also investigated the inhibitory effect of P. tenuipes extract on the expression of angiogenesis-related genes including VEGF, MMP-2, MMP-9, TIMP-1, and TIMP-2. P. tenuipes extract significantly down-regulated the expression of MMP-2 and MMP-9 in a dose-dependent manner. On the contrary, P. tenuipes increased the expression of TIMP-1 and TIMP-2. Our findings indicate that P. tenuipes exhibits an inhibitory effect on angiogenesis in human prostate cancer cells.

Keywords

Angiogenesis;LNCaP;Paecilomyces tenuipes;Prostate cancer

Acknowledgement

Supported by : 한국연구재단, 농림식품기술기획평가원

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