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Effects of Pleurotus eryngii extract against inflammation in activated RAW 264.7 cells and UV-induced skin damage in mice

활성 RAW 264.7 세포에서 항염증 및 자외선 유도 마우스 피부손상의 개선에 대한 새송이 추출물의 효과

  • 조병옥 ((주)아토큐앤에이 기업부설연구소) ;
  • 윤홍화 ((주)아토큐앤에이 기업부설연구소) ;
  • 이현서 (전주대학교 보건관리학과) ;
  • 추정임 (전주대학교 농생명치유산업연구소) ;
  • 장선일 ((주)아토큐앤에이 기업부설연구소)
  • Received : 2016.08.22
  • Accepted : 2016.10.07
  • Published : 2017.02.28

Abstract

The aim of this study was to investigate the anti-inflammatory and ultraviolet (UV)-protective effect of Pleurotus eryngii extract (PEE) in activated RAW 264.7 cells and UV-induced mouse skin damage. The results showed that PEE strongly inhibited the production of inflammatory mediators such as nitric oxide, interleukin $(IL)-1{\beta}$, and IL-6 at high concentrations in LPS-stimulated RAW 264.7 macrophages. In addition, PEE treatment suppressed erythema, melanin index, and epidermal thickness to a greater degree than ascorbic acid (AA) treatment in UV-irradiated mice. Finally, PEE treatment inhibited the infiltration of mast cell to a similar degree of AA treatment. Therefore, these results indicate that PEE could improve inflammation and skin damage in immune cells and UV-irradiated mice. This study may provide positive insights into PEE as a functional food and cosmetic ingredient for treatment of inflammation and skin damage.

Keywords

Pleurotus eryngii;anti-inflammation;UV-induced skin damage;protective effect

Acknowledgement

Supported by : 한국산업기술진흥원

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