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The Effect of Taping Therapy on the Expression of cFos Protein and Pain Suppression in Acute Ankle Sprain in Rats

흰쥐의 급성 발목삠에서 테이핑요법이 cFos 단백의 발현과 통증억제에 미치는 영향

  • Choi, Suck-Jun (Department of Medical Noncommissioned Officer, Wonkwang Health Science University) ;
  • Byun, Sin-Kyu (Department of Combat Noncommissioned Officer, Wonkwang Health Science University) ;
  • Lee, Gyoung-Wan (Department of Nursing, Wonkwang Health Science University) ;
  • Kim, Jae-Hyo (Department of Meridian & Acupoint, College of Korean Medicine, Wonkwang University) ;
  • Yang, Seung-Bum (Department of Medical Noncommissioned Officer, Wonkwang Health Science University)
  • 최석준 (원광보건대학교 의무부사관과) ;
  • 변신규 (원광보건대학교 전투부사관과) ;
  • 이경완 (원광보건대학교 간호학과) ;
  • 김재효 (원광대학교 한의과대학 경혈학교실) ;
  • 양승범 (원광보건대학교 의무부사관과)
  • Received : 2017.02.06
  • Accepted : 2017.03.14
  • Published : 2017.03.27

Abstract

Objectives : The purpose of this study was to evaluate effects of taping therapy on recovery of behavioral symptoms and neural excitability of the lumbar spinal cord in rat model for ankle sprain. Methods : Adult Sprague-Dawley rats was used and divided into 3 experimental groups: normal group(n=6), ankle sprain(n=6), and ankle sprain with taping treatment(n=6). In order to induce ankle sprain the right ankle joint was injured with 4~5 repetitive over-flexions and over-extensions manually. The severity of joint pain was evaluated by measuring foot weight bearing force ratio(FWBRF) of the hind limb and the injury-induced edema formation by diameter of the joint following ankle sprain. The changes of neural excitability in the lumbar spinal cord was tested by observation of cFos protein expression, a metabolic marker for neural excitation. Results : Severity of ankle injury induced in this experiment coincided with Grade 1 ankle sprain. Compared with ankle sprain group, ankle sprain+taping showed a significant reductions of joint pain as well as of edema formation at the ankle joint following ankle sprain. There was significant upregulation of cFos-immunoreactive neurons in the lumbar spinal cord 24 hours after ankle sprain. In contrast, taping therapy resulted in significant inhibition of cFos-immunoreactive neurons in the lumbar spinal cord. Conclusions : Collectively, these results suggest that taping therapy may be an alternative therapeutic intervention for symptom recovery of the mild ankle sprain.

Acknowledgement

Supported by : Wonkwang Health Science University

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