Current Research on Conducting Polymer-Carbon Nanocomposites for Bioengineering Applications

  • Lee, Seunghyeon (Department of Chemical Engineering, Inha University) ;
  • Lee, Sang Kyu (Department of Chemical Engineering, Inha University) ;
  • Jang, Daseul (Department of Chemical Engineering, Inha University) ;
  • Shim, Bong Sup (Department of Chemical Engineering, Inha University)
  • Received : 2017.03.02
  • Accepted : 2017.03.06
  • Published : 2017.03.31


Conducting polymers and carbon nanomaterials offer a wide range of applications because of their unique soft conducting properties. Specifically, these conducting polymer-carbon nanocomposites have recently been utilized in bioengineering applications, partly because of their improved biocompatibility compared to conventional conducting materials such as metals and ceramics. Based on the assumption that these composites offer an important application potential as functional materials for biomedical devices or even as biomaterials, this review surveys the recent research trends on conducting polymers-carbon nanocomposites, focusing on bioengineering applications such as polyaniline (PANI), poly(3,4-ethylenedioxythiophene) or PEDOT, polypyrrole (Ppy), and carbon nanotubes and graphene.


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  1. C. K. Chiang, et al. Electrical conductivity in doped polyacetylene. Physical Review Letters 39, 1098 (1977).
  2. N. K. Guimard, N. Gomez, and C. E. Schmidt, "Conducting polymers in biomedical engineering", Progress in Polymer Science 32, 876 (2007).
  3. A. Pron and P. Rannou, "Processible conjugated polymers: from organic semiconductors to organic metals and superconductors", Progress in Polymer Science 27, 135 (2002).
  4. J.-C. Chiang and A. G. MacDiarmid, "'Polyaniline': Protonic acid doping of the emeraldine form to the metallic regime", Synthetic Metals 13, 193 (1986).
  5. J. Stejskal and R. G. Gilbert, "Polyaniline. Preparation of a conducting polymer (IUPAC technical report)", Pure and Applied Chemistry 74, 857 (2002).
  6. X. Crispin, et al. "Conductivity, morphology, interfacial chemistry, and stability of poly(3,4-ethylene dioxythiophene)-poly(styrene sulfonate): A photoelectron spectroscopy study", Journal of Polymer Science Part B-Polymer Physics 41, 2561 (2003).
  7. J. Wu, Morphology of poly (3,4-ethylene dioxythiophene) (PEDOT) thin films, crystals, cubic phases, fibers and tubes. (2011).
  8. B. L. Groenendaal, F. Jonas, D. Freitag, H. Pielartzik, and J. R. Reynolds, "Poly(3,4-ethylenedioxythiophene) and its derivatives: Past, present, and future", Advanced Materials 12, 481 (2000).<481::AID-ADMA481>3.0.CO;2-C
  9. M. J. Allen, V. C. Tung, and R. B. Kaner, "Honeycomb Carbon: A Review of Graphene", Chemical Reviews 110, 132 (2010).
  10. X. Y. Zhang, et al. "Distribution and biocompatibility studies of graphene oxide in mice after intravenous administration", Carbon 49, 986 (2011).
  11. G. K. M. Mutlu, et al. "Biocompatible Nanoscale Dispersion of Single-Walled Carbon Nanotubes Minimizes in vivo Pulmonary Toxicity", Nano Letters 10, 1664 (2010).
  12. C. A. Poland, et al. "Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study", Nature Nanotechnology 3, 423 (2008).
  13. C. Bussy, H. Ali-Boucetta, and K. Kostarelos, "Safety Considerations for Graphene: Lessons Learnt from Carbon Nanotubes", Accounts of Chemical Research 46, 692 (2012).
  14. O. Breuer and U. Sundararaj, "Big returns from small fibers: A review of polymer/carbon nanotube composites", Polymer Composites 25, 630 (2004).
  15. M. Moniruzzaman and K. I. Winey, "Polymer Nanocomposites Containing Carbon Nanotubes", Macromolecules 39, 5194 (2006).
  16. P. J. F. Harris, "Carbon nanotube composites", International Materials Reviews 49, 31 (2004).
  17. Z. Spitalsky, D. Tasis, K. Papagelis, and C. Galiotis, "Carbon nanotube-polymer composites: Chemistry, processing, mechanical and electrical properties", Progress in Polymer Science 35, 357 (2010).
  18. X.-L. Xie, Y.-W. Mai, and X.-P. Zhou, "Dispersion and alignment of carbon nanotubes in polymer matrix: A review", Materials Science and Engineering: R: Reports 49, 89 (2005).
  19. C. Peng, S. Zhang, D. Jewell, and G. Z. Chen, "Carbon nanotube and conducting polymer composites for supercapacitors", Progress in Natural Science 18, 777 (2008).
  20. F. Qu, M. Yang, J. Jiang, G. Shen, and R. Yu, "Amperometric biosensor for choline based on layer-by-layer assembled functionalized carbon nanotube and polyaniline multilayer film", Analytical Biochemistry 344, 108 (2005).
  21. M. N. Hyder, et al. "Layer-by-Layer Assembled Polyaniline Nanofiber/Multiwall Carbon Nanotube Thin Film Electrodes for High-Power and High-Energy Storage Applications", ACS Nano 5, 8552 (2011).
  22. M. D. Shirsat, C. O. Too, and G. G. Wallace, "Amperometric Glucose Biosensor on Layer by Layer Assembled Carbon Nanotube and Polypyrrole Multilayer Film", Electroanalysis 20, 150 (2008).
  23. D. Shao, et al. "Polyaniline Multiwalled Carbon Nanotube Magnetic Composite Prepared by Plasma-Induced Graft Technique and Its Application for Removal of Aniline and Phenol", The Journal of Physical Chemistry C 114, 21524 (2010).
  24. T. Wu, Y. Pan, H. Bao, and L. Li, "Preparation and properties of chitosan nanocomposite films reinforced by poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) treated carbon nanotubes", Materials Chemistry and Physics 129, 932 (2011).
  25. M. Ghaffari, et al. "Hybrid supercapacitor materials from poly(3,4-ethylenedioxythiophene) conformally coated aligned carbon nanotubes", Electrochimica Acta 112, 522 (2013).
  26. H. Mi, X. Zhang, S. An, X. Ye, and S. Yang, "Microwaveassisted synthesis and electrochemical capacitance of polyaniline/multi-wall carbon nanotubes composite", Electrochemistry Communications 9, 2859 (2007).
  27. Y.-K. Lee, K.-J. Lee, D.-S. Kim, D.-J. Lee, and J.-Y. Kim, "Polypyrrole-carbon nanotube composite films synthesized through gas-phase polymerization", Synthetic Metals 160, 814 (2010).
  28. Y.-S. Chen, Y. Li, H.-C. Wang, and M.-J. Yang, "Gas sensitivity of a composite of multi-walled carbon nanotubes and polypyrrole prepared by vapor phase polymerization", Carbon 45, 357 (2007).
  29. L. Li, et al. "Facile Fabrication of Uniform Core-Shell Structured Carbon Nanotube-Polyaniline Nanocomposites", The Journal of Physical Chemistry C 113, 5502 (2009).
  30. L. Chen, et al. "Synthesis and electrochemical capacitance of core-shell poly (3,4-ethylenedioxythiophene)/poly (sodium 4-styrenesulfonate)-modified multiwalled carbon nanotube nanocomposites", Electrochimica Acta 54, 2335 (2009).
  31. J. Wang, "Amperometric biosensors for clinical and therapeutic drug monitoring: A review", Journal of Pharmaceutical and Biomedical Analysis 19, 47 (1999).
  32. L. D. Mello and L. T. Kubota, "Review of the use of biosensors as analytical tools in the food and drink industries", Food Chemistry 77, 237 (2002).
  33. J. Wang, et al. "DNA electrochemical biosensors for environmental monitoring. A review", Analytica Chimica Acta 347, 1 (1997).
  34. B. D. Malhotra, A. Chaubey, and S. P. Singh, "Prospects of conducting polymers in biosensors", Analytica Chimica Acta 578, 59 (2006).
  35. P. R. Unwin and A. J. Bard, "Ultramicroelectrode voltammetry in a drop of solution: a new approach to the measurement of adsorption isotherms at the solid-liquid interface", Analytical Chemistry 64, 113 (1992).
  36. M. Liu, et al. "An Amperometric Biosensor Based on Ascorbate Oxidase Immobilized in Poly(3,4-ethylenedioxythiophene)/Multi-Walled Carbon Nanotubes Composite Films for the Determination of L-Ascorbic Acid", Analytical Sciences 27, 477 (2011).
  37. N. Kaur, H. Thakur, and N. Prabhakar, "Conducting polymer and multi-walled carbon nanotubes nanocomposites based amperometric biosensor for detection of organophosphate", Journal of Electroanalytical Chemistry 775, 121 (2016).
  38. I. M. Taylor, et al. "Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes", Biosensors & Bioelectronics 89, 400 (2017).
  39. S. R. Teixeira, et al. "Polyaniline-graphene based ${\alpha}$-amylase biosensor with a linear dynamic range in excess of 6 orders of magnitude", Biosensors and Bioelectronics 85, 395 (2016).
  40. E. Bayram and E. Akyilmaz, "Development of a new microbial biosensor based on conductive polymer/multiwalled carbon nanotube and its application to paracetamol determination", Sensors and Actuators B-Chemical 233, 409 (2016).
  41. H. T. Hien, H. T. Giang, T. Trung, and C. V. Tuan, "Enhancement of biosensing performance using a polyaniline/multiwalled carbon nanotubes nanocomposite", Journal of Materials Science 52, 1694 (2017).
  42. S. Wu, et al. "Development of glucose biosensors based on plasma polymerization-assisted nanocomposites of polyaniline, tin oxide, and three-dimensional reduced graphene oxide", Applied Surface Science 401, 262 (2017).
  43. A. Jasim, M. W. Ullah, Z. Shi, X. Lin, and G. Yang, "Fabrication of bacterial cellulose/polyaniline/single-walled carbon nanotubes membrane for potential application as biosensor", Carbohydrate Polymers 163, 62 (2017).
  44. X. Kan, et al. "Imprinted electrochemical sensor for dopamine recognition and determination based on a carbon nanotube/polypyrrole film", Electrochimica Acta 63, 69 (2012).
  45. P. D. Tam and N. V. Hieu, "Conducting polymer film-based immunosensors using carbon nanotube/antibodies doped polypyrrole", Applied Surface Science 257, 9817 (2011).
  46. L. Wang, et al. "Highly Sensitive Detection of Quantal Dopamine Secretion from Pheochromocytoma Cells Using Neural Microelectrode Array Electrodeposited with Polypyrrole Graphene", ACS Applied Materials & Interfaces 7, 7619 (2015).
  47. N. Chauhan, R. Rawal, V. Hooda, and U. Jain, "Electrochemical biosensor with graphene oxide nanoparticles and polypyrrole interface for the detection of bilirubin", Rsc Advances 6, 63624 (2016).
  48. L. T. Yang, J. Yang, B. J. Xu, F. Q. Zhao, and B. Z. Zeng, "Facile preparation of molecularly imprinted polypyrrole-graphenemultiwalled carbon nanotubes composite film modified electrode for rutin sensing", Talanta 161, 413 (2016).
  49. D. Ye, L. Luo, Y. Ding, Q. Chen, and X. Liu, "A novel nitrite sensor based on graphene/polypyrrole/chitosan nanocomposite modified glassy carbon electrode", Analyst 136, 4563 (2011).
  50. N. Ruecha, R. Rangkupan, N. Rodthongkum, and O. Chailapakul, "Novel paper-based cholesterol biosensor using graphene/polyvinylpyrrolidone/polyaniline nanocomposite", Biosensors & Bioelectronics 52, 13 (2014).
  51. K. Radhapyari, P. Kotoky, M. R. Das, and R. Khan, "Graphenepolyaniline nanocomposite based biosensor for detection of antimalarial drug artesunate in pharmaceutical formulation and biological fluids", Talanta 111, 47 (2013).
  52. W. Lei, et al. "Microwave-assisted synthesis of hemingraphene/poly(3,4-ethylenedioxythiophene) nanocomposite for a biomimetic hydrogen peroxide biosensor", Journal of Materials Chemistry B 2, 4324 (2014).
  53. P. M. Nia, W. P. Meng, F. Lorestani, M. R. Mahmoudian, and Y. Alias, "Electrodeposition of copper oxide/polypyrrole/reduced graphene oxide as a nonenzymatic glucose biosensor", Sensors and Actuators B-Chemical 209, 100 (2015).
  54. K. Xue, et al. "A novel amperometric glucose biosensor based on ternary gold nanoparticles/polypyrrole/reduced graphene oxide nanocomposite", Sensors and Actuators B-Chemical 203, 412 (2014).
  55. J. Li, et al. "Electrochemical immunosensor based on graphenepolyaniline composites and carboxylated graphene oxide for estradiol detection", Sensors and Actuators B-Chemical 188, 99 (2013).
  56. M. M. Barsan, V. Pifferi, L. Falciola, and C. M. A. Brett, "New CNT/poly(brilliant green) and CNT/poly(3,4-ethylenedioxythiophene) based electrochemical enzyme biosensors", Analytica Chimica Acta 927, 35 (2016).
  57. G. Orive, E. Anitua, J. L. Pedraz, and D. F. Emerich, "Biomaterials for promoting brain protection, repair and regeneration", Nature Reviews Neuroscience 10, 6825 (2009).
  58. Y. Xiao, X. Ye, L. He, and J. Che, "New carbon nanotubeconducting polymer composite electrodes for drug delivery applications", Polymer International 61, 190 (2012).
  59. C. L. Weaver, J. M. LaRosa, X. Luo, and X. T. Cui, "Electrically Controlled Drug Delivery from Graphene Oxide Nanocomposite Films", Acs Nano 8, 1834 (2014).
  60. S. F. Cogan, in Annual Review of Biomedical Engineering Vol. 10 Annual Review of Biomedical Engineering 275 (2008).
  61. Y. Nam, "Material considerations for in vitro neural interface technology", Mrs Bulletin 37, 566 (2012).
  62. M. A. L. Nicolelis, et al. "Chronic, multisite, multielectrode recordings in macaque monkeys", Proceedings of the National Academy of Sciences of the United States of America 100, 11041 (2003).
  63. A. Goryu, R. Numano, A. Ikedo, M. Ishida, and T. Kawano, "Nanoscale tipped microwire arrays enhance electrical trap and depth injection of nanoparticles", Nanotechnology 23, 415301 (2012).
  64. B. Rubehn, C. Bosman, R. Ostenveld, P. Fries, and T. Stieglitz, "A MEMS-based flexible multichannel ECoG-electrode array", Journal of Neural Engineering 6, 036003 (2009).
  65. L. R. Hochberg, et al. "Neuronal ensemble control of prosthetic devices by a human with tetraplegia", Nature 442, 164 (2006).
  66. D. R. Kipke, et al. "Advanced Neurotechnologies for Chronic Neural Interfaces: New Horizons and Clinical Opportunities", Journal of Neuroscience 28, 11830 (2008).
  67. X. Y. Cui and D. C. Martin, "Electrochemical deposition and characterization of poly(3,4-ethylenedioxythiophene) on neural microelectrode arrays", Sensors and Actuators B-Chemical 89, 92 (2003).
  68. M. R. Abidian and D. C. Martin, "Experimental and theoretical characterization of implantable neural microelectrodes modified with conducting polymer nanotubes", Biomaterials 29, 1273 (2008).
  69. S. P. Lacour, et al. "Flexible and stretchable micro-electrodes for in vitro and in vivo neural interfaces", Medical & Biological Engineering & Computing 48, 945 (2010).
  70. D. H. Kim, et al. "Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics", Nature Materials 9, 511 (2010).
  71. D. C. Rodger, et al. "Flexible parylene-based multielectrode array technology for high-density neural stimulation and recording", Sensors and Actuators B-Chemical 132, 449 (2008).
  72. S. Negi, R. Bhandari, L. Rieth, R. Van Wagenen, and F. Solzbacher, "Neural electrode degradation from continuous electrical stimulation: Comparison of sputtered and activated iridium oxide", Journal of Neuroscience Methods 186, 8 (2010).
  73. Y. Lu, et al. "Electrodeposited polypyrrole/carbon nanotubes composite films electrodes for neural interfaces", Biomaterials 31, 5169 (2010).
  74. H. Zhou, X. Cheng, L. Rao, T. Li, and Y. Y. Duan, "Poly(3,4-ethylenedioxythiophene)/multiwall carbon nanotube composite coatings for improving the stability of microelectrodes in neural prostheses applications", Acta Biomaterialia 9, 6439 (2013).
  75. X. Luo, C. L. Weaver, D. D. Zhou, R. Greenberg, and X. T. Cui, "Highly stable carbon nanotube doped poly(3,4-ethylenedioxythiophene) for chronic neural stimulation", Biomaterials 32, 5551 (2011).
  76. Kolarcik, Christi L., et al. "Evaluation of poly(3,4-ethylenedioxythiophene)/carbon nanotube neural electrode coatings for stimulation in the dorsal root ganglion", Journal of Neural Engineering 12, 016008 (2015).
  77. X. Luo, C. L. Weaver, S. Tan, and X. T. Cui, "Pure graphene oxide doped conducting polymer nanocomposite for bio-interfacing", Journal of Materials Chemistry B 1, 1340 (2013).
  78. H.-C. Tian, et al. "Graphene oxide doped conducting polymer nanocomposite film for electrode-tissue interface". Biomaterials 35, 2120 (2014).
  79. T. Hong-Chang, et al. in Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE. 1571.
  80. T. D. Y. Kozai, et al. "Chronic In Vivo Evaluation of PEDOT/CNT for Stable Neural Recordings", Ieee Transactions on Biomedical Engineering 63, 111 (2016).
  81. C. T. Chen, et al. "Biointerface by Cell Growth on Graphene Oxide Doped Bacterial Cellulose/Poly(3,4-ethylenedioxythiophene) Nanofibers", Acs Applied Materials & Interfaces 8, 10183 (2016).
  82. L. Yan, et al. "Aligned Nanofibers from Polypyrrole/Graphene as Electrodes for Regeneration of Optic Nerve via Electrical Stimulation", Acs Applied Materials & Interfaces 8, 6834 (2016).
  83. X. Yang, et al. "Superparamagnetic graphene oxide-$Fe_3O_4$ nanoparticles hybrid for controlled targeted drug carriers", Journal of Materials Chemistry 19, 2710 (2009).
  84. Z. Liu, J. T. Robinson, X. Sun, and H. Dai, "PEGylated nanographene oxide for delivery of water-insoluble cancer drugs", Journal of the American Chemical Society 130, 10876 (2008).