Effects of Polygonatum sibiricum rhizome extract on lipid and energy metabolism in high-fat diet-induced obese mice

고지방 식이 유도 비만 마우스 모델에서 황정 추출물의 지방질 및 에너지 대사 관련 유전자에 대한 효능 연구

  • Jeon, Woo-Jin (Research Laboratories, Ildong Pharmaceutical Co., Ltd.) ;
  • Kim, Ji-Young (Research Laboratories, Ildong Pharmaceutical Co., Ltd.) ;
  • Oh, Ik-Hoon (Research Laboratories, Ildong Pharmaceutical Co., Ltd.) ;
  • Lee, Do-Seop (Research Laboratories, Ildong Pharmaceutical Co., Ltd.) ;
  • Shon, Suh-Youn (Research Laboratories, Ildong Pharmaceutical Co., Ltd.) ;
  • Seo, Yun-Ji (Research Laboratories, Ildong Pharmaceutical Co., Ltd.) ;
  • Yeon, Seung-Woo (Research Laboratories, Ildong Pharmaceutical Co., Ltd.) ;
  • Kang, Jae-Hoon (Research Laboratories, Ildong Pharmaceutical Co., Ltd.)
  • 전우진 (일동제약(주) 중앙연구소) ;
  • 김지영 (일동제약(주) 중앙연구소) ;
  • 오익훈 (일동제약(주) 중앙연구소) ;
  • 이도섭 (일동제약(주) 중앙연구소) ;
  • 손서연 (일동제약(주) 중앙연구소) ;
  • 서윤지 (일동제약(주) 중앙연구소) ;
  • 연승우 (일동제약(주) 중앙연구소) ;
  • 강재훈 (일동제약(주) 중앙연구소)
  • Received : 2016.09.13
  • Accepted : 2016.12.21
  • Published : 2017.04.30


In this study, factors involved in lipid and energy metabolism following treatment with ethanolic extract of the Polygonatum sibiricum rhizome (ID1216) were evaluated in high-fat diet-induced obese mice. ID1216-treated mice showed a significant reduction in weight gain compared to non-treated mice. ID1216 treatment increased the protein levels of AMP-dependent protein kinase, sirtuin1, peroxisome proliferator-activated receptor ${\gamma}$ coactivator 1-${\alpha}$ ($PGC1{\alpha}$), peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) and uncoupling proteins in the adipose tissue, liver and muscle compared to vehicle treatment. Analysis of downstream signals of the sirtuin1 $PGC1{\alpha}$-$PPAR{\alpha}$ pathway showed that ID1216 regulates the expression of ${\beta}$-oxidation related genes such as acyl-CoA oxidase, carnitine palmitoyltransferase1, acyl-CoA dehydrogenase and adipocyte protein 2. In addition, ID1216 increased the expression of adipose triglyceride lipase. These results suggest that ID1216 has anti-obesity effects by regulating the genes involved thermogenesis, ${\beta}$-oxidation and lipolysis in a diet-induced obesity model.


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