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Effects of hot water extracts of roasted radish against renal oxidative stress induced by high-fat diet

고지방식사로 유도된 신장 산화스트레스를 개선하는 가압볶음 무말랭이 열수추출물 효과

  • Jeon, Yeonhui (Department of Food Science and Nutrition, Kimchi Research Institute, Pusan National University) ;
  • Kim, Mijeong (Department of Food Science and Nutrition, Kimchi Research Institute, Pusan National University) ;
  • Han, Seongkyung (Department of Food Science and Nutrition, Kimchi Research Institute, Pusan National University) ;
  • Song, Yeong-Bok (Sejeon Co., Ltd.) ;
  • Song, Yeong Ok (Department of Food Science and Nutrition, Kimchi Research Institute, Pusan National University)
  • 전연희 (부산대학교 식품영양학과 및 김치연구소) ;
  • 김미정 (부산대학교 식품영양학과 및 김치연구소) ;
  • 한성경 (부산대학교 식품영양학과 및 김치연구소) ;
  • 송영복 ((주)세전식품연구소) ;
  • 송영옥 (부산대학교 식품영양학과 및 김치연구소)
  • Received : 2016.09.24
  • Accepted : 2016.12.12
  • Published : 2017.04.30

Abstract

The antioxidant and anti-inflammatory effects of roasted dried radish (RDR) against renal oxidative stress were examined in high-fat diet (HFD)-fed mice. The HFD was prepared by adding lard to chow diet to provide 50% of the calories from fat. Hot water extracts of dried radish (DR) or RDR were administered orally to mice at 237 mg/kg bw/day, whereas distilled water was administered as a vehicle for 12 weeks. Compared to the control group, renal reactive oxygen species, peroxynitrite, and thiobarbituric acid reactive substance level in the DR or RDR group were significantly decreased, whereas the glutathione level was increased (p<0.05). Protein expressions of antioxidant factors such as nuclear factor erythroid 2-related factor-2, heme oxygenase-1, glutathione S-transferase, superoxide dismutase, catalase, and glutathione peroxidase were significantly increased in the DR and RDR groups; however, nuclear factor-kappa B expression was suppressed (p<0.05). These antioxidant and anti-inflammatory effects of RDR were found to be significantly greater than those of DR.

Keywords

radish;roasting;kidney;antioxidant effect;anti-inflammatory effect

Acknowledgement

Supported by : (주)세전

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