- Volume 57 Issue 2
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Candida albicans urinary tract infection in a Shih Tzu dog with immune-mediated hemolytic anemia
- Jang, In-Sung (Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University) ;
- Yoon, Won-Kyoung (Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University) ;
- Hyun, Changbaig (Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University)
- Received : 2017.02.04
- Accepted : 2017.06.05
- Published : 2017.06.30
An 8-year-old castrated male Shih Tzu dog (weighing 7.0 kg) presented with anemia and lethargy. Initial diagnosis indicated immune-mediated hemolytic anemia. During therapy, a secondary urinary infection, probably due to the immune suppressive therapy, was diagnosed. Subsequent diagnostic tests, including urinalysis and urine culture, indicated candidal cystitis. Despite ketoconazole therapy for candidal cystitis, the dog died suddenly. A Candida albicans infection was confirmed upon postmortem evaluation. Prolonged immunosuppressive therapy might be the cause of this infection. This is the first case report describing a Candida albicans urinary tract infection accompanied by hemolytic anemia in a dog in Korea.
- Choi US. [Practical Guide to Diagnostic Cytology of the Dog and Cat]. 1st ed. pp. 351, OKVET, Daejeon, 2012. Korean.
- Edelmann A, Kruger M, Schmid J. Genetic relationship between human and animal isolates of Candida albicans. J Clin Microbiol 2005, 43, 6164-6166. https://doi.org/10.1128/JCM.43.12.6164-6166.2005
- Forward ZA, Legendre AM, Khalsa HD. Use of intermittent bladder infusion with clotrimazole for treatment of candiduria in a dog. J Am Vet Med Assoc 2002, 220, 1496-1498. https://doi.org/10.2460/javma.2002.220.1496
- Humphrey MJ, Jevons S, Tarbit MH. Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humans. Antimicrob Agents Chemother 1985, 28, 648-653. https://doi.org/10.1128/AAC.28.5.648
- Jin Y, Lin D. Fungal urinary tract infections in the dog and cat: a retrospective study (2001-2004). J Am Anim Hosp Assoc 2005, 41, 373-381. https://doi.org/10.5326/0410373
- Karlowsky JA, Zhanel GG, Klym KA, Hoban DJ, Kabani AM. Candidemia in a Canadian tertiary care hospital from 1976 to 1996. Diagn Microbiol Infect Dis 1997, 29, 5-9. https://doi.org/10.1016/S0732-8893(97)00068-0
- Manolakaki D, Velmahos G, Kourkoumpetis T, Chang, Y, Alam HB, De Moya MM, Mylonakis E. Candida infection and colonization among trauma patients. Virulence 2010, 1, 367-375. https://doi.org/10.4161/viru.1.5.12796
- Pappas PG, Rex JH, Sobel JD, Filler SG, Dismukes WE, Walsh TJ, Edwards JE. Guidelines for treatment of candidiasis. Clin Infect Dis 2004, 38, 161-189. https://doi.org/10.1086/380796
- Pressler BM. Candidiasis and rhodotorulosis. In: Greene CE (ed.). Infectious Diseases of the Dog and Cat. 4th ed. pp. 666-671, Saunders, Philadelphia, 2012.
- Pressler BM, Vaden SL, Lane IF, Cowgill LD, Dye JA. Candida spp. urinary tract infections in 13 dogs and seven cats: predisposing factors, treatment, and outcome. J Am Anim Hosp Assoc 2003, 39, 263-270. https://doi.org/10.5326/0390263
- Warren NG, Hazen KC. Candida, Cryptococcus, and other yeasts of medical importance. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH (eds.). Manual of Clinical Microbiology. 7th ed. pp. 1184-1199, ASM press, Washington DC, 1999.