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Fabrication of PCL Scaffolds According to Various Pore Patterns Using Polymer Deposition System and Design of Experiments

폴리머 적층 시스템과 실험계획법을 이용한 다양한 공극 패턴에 따른 PCL 인공지지체의 제작 연구

  • Sa, Min-Woo (Dept. of Mechanical Engineering, Andong Nat'l Univ.) ;
  • Choi, Sun-Woong (Dept. of Mechanical Engineering, Andong Nat'l Univ.) ;
  • Lee, Jae-Wook (Dept. of Mechanical Engineering, Andong Nat'l Univ.) ;
  • Kim, Jong Young (Dept. of Mechanical Engineering, Andong Nat'l Univ.)
  • 사민우 (안동대학교 기계공학과) ;
  • 최선웅 (안동대학교 기계공학과) ;
  • 이재욱 (안동대학교 기계공학과) ;
  • 김종영 (안동대학교 기계공학과)
  • Received : 2017.03.08
  • Accepted : 2017.04.04
  • Published : 2017.07.01

Abstract

In bone tissue engineering, polycaprolactone (PCL) is one of the most widely used biomaterials in the manufacturing of scaffolds as a synthetic polymer having biodegradability and biocompatibility. The strut width in the fabrication of scaffolds is an important part of tissue regeneration in in-vitro and in-vivo experiments, because it affects not only the pore size but also the porosity. In this study, we used polymer deposition system (PDS) and design of experiments (DOE) to explore the optimal process conditions to achieve a systematic and efficient scaffold manufacturing process, using temperature, pressure, scan velocity, and nozzle tip height as the parameters for the experiments. The aim of this research was to fabricate a 3D PCL scaffold having a uniform strut width of $150{\mu}m$ using DOE; it was proved that the strut width was constant in all the experimental groups by fabricating the PCL scaffolds according to various pore patterns as well as one pore pattern.

Keywords

Polymer Deposition System;Polycaprolactone Scaffold;Pore Pattern;Design of Experiment

Acknowledgement

Supported by : 한국연구재단

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