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The Effect of Oral Administration at Herbal Medicines in Animal Models on Obesity: A Review of Animal Study Reports Published in Korea after 2010

동물실험에서 한약제재 경구투여가 비만에 미치는 영향에 대한 국내 연구보고 고찰 - 2010년 이후 발표된 논문을 중심으로

  • Received : 2017.06.19
  • Accepted : 2017.07.02
  • Published : 2017.07.31

Abstract

Objectives This study is to review the effect of herbal medicines on obesity in animal models reported in Korean domestic journals after 2010. Methods The Databases (Koreantk, KISS, NDSL) are searched with terms as obesity, and animal study reports on obesity with herbal medicines after 2010 were reviewed. Animal model, intervention, and obesity indicator were extracted. Results 69 articles were reviewed. 57 studies used high fat diet to induce obesity. 56 studies used complex herbal medicines. Most used herbal material for anti-obesity effect is Ephedrae Herba. Each study shows significant changes of obesity indicators. Conclusions These results suggest that herbal medicine is effective treatment to obesity. But we need continuously agonize and research more effective and safe herbal medicine.

Keywords

Obesity;Herbal medicine;Animal Model;Review

References

  1. The society of korean medicine rehabilitation. Oriental rehabilitation medicine. The 3rd edition. Seoul:Koonja. 2012;350-63.
  2. Kurt J. Harrison's Principles of internal medicine. NewYork:Isselbacher. 1994;446-52.
  3. Lang A, Froelicher ES. Management of overweight and obesity in adults: Behavioral intervention for long-term weight loss and maintenance. Eur J Cardiovas Nurs. 2006;5:102-14. https://doi.org/10.1016/j.ejcnurse.2005.11.002
  4. Padwal RS, Majumdar SR. Drug treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet. 2007;369 (9555):71-7. https://doi.org/10.1016/S0140-6736(07)60033-6
  5. Yin J, Zhang H, Ye J. Traditional chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disorder Drug Target. 2008;8(2):99-111. https://doi.org/10.2174/187153008784534330
  6. Kim DH, Lee JH. 注解補注 黃帝內經 素問(上). Seoul: Esdang. 2001;652,974.
  7. Hu SY, Kang HS. Oriental and Western Study on Obesity and Treatment. Journal of Korean Medicine Rehabilitation. 1997;7(1):272-86.
  8. Ko SC, Jeong KM. The Study about the Comparison of Oriental-Western Medicine on Childhood Obesity. Journal Korean Oreintal Pediatrics. 1989;3(1):57-61.
  9. Park C. Review on the literatures of obesity experiments published in the journal of Korean medicine. Master's thesis of Wonkwang university. 2007;1-41.
  10. Park BY, Song YK, Lim HH. An analysis of domestic oriental medicine study tendency on obesity - Focused on domestic academic journal since 2006 -. Journal of Society of Korean Medicine for Obesity Research. 2010;10(2):1-16.
  11. Ye SA, Kim HJ, Ko SG, Song YK. Influence of Galgeun-tang on Gene Expression in Diet-Induced Obese Mice. Journal of Korean Medicine Rehabilitation. 2016; 26(2):1-12.
  12. Oh MJ, Lee CH, Kim HJ, Kim HR, Kim MS, Lee DY et al. The comparative studies on anti-obesity effects of Ephedrae Herba and Cyperi rhizoma in high fat diet fed mice. Herbal Formula Science. 2016;24(2):108-23. https://doi.org/10.14374/HFS.2016.24.2.108
  13. Lee HI, Lee JH, Kwon YM, Song YS. Effects of Gami-Handayeolso-Tang on Body Fat Reduction in High Fat Diet-Fed Obese Mice. Journal of Korean Medicine Rehabilitation. 2016;26(1):13-31.
  14. Jang YE, Seo BI. The Anti-obesity Effects of Platycodi Radix, Combination of Platycodi Radix and Cyperi Rhizoma on Obesity Induced by High Fat Diet. Kor J Herbology. 2016;31(3):1-11.
  15. Song MY, Jung HW, Park YK. Antiobesity Effect of Water Extract of Coix lacrymajobi var. mayuen in High Fat Fed C5BL/6 Mice. J Korean Med Obes Res. 2016;16(1):27-35. https://doi.org/10.15429/jkomor.2016.16.1.27
  16. Ma YH, Kim HJ, Han YH, Kim HO, Oh JS. Effects of Cortex Phellodendri on the Metabolic Function in Experimental Mouse Model of Obesity. J Int Korean Med. 2015;36(4):447-57.
  17. Kim YM, Kim MH, Yang WM. Effects of Agastache rugosa on Obesity Via Inhibition off Peroxisome Proliferator-Activated Receptor-Gamma and Reduction of Food Intake. J Korean Med Obes Res. 2015;15(2):104-10. https://doi.org/10.15429/jkomor.2015.15.2.104
  18. Choi HM, Moon SO, Lee HH, Lee HD. Inhibitory effect of by Ojeok-san lipid accumulation in high fat diet-induced obesity mice and 3T3-L1 adipocytes. Kor J Herbol. 2015;30(4):121-8. https://doi.org/10.6116/kjh.2015.30.4.121.
  19. Yoo JS, Ku JR, Yoon KH, Jo JH, Jang DH, Jung YS et al. Comparison of Gangji-hwan-1, 2, 3, 4 and Combination of Gangji-hwan-1 and Gamisoche-hwan in the Reducing Effects of Body Weight in a High Fat Diet-Fed Obese Mice. J Korean Med Obes Res. 2015;15(1):9-23. https://doi.org/10.15429/jkomor.2015.15.1.9
  20. Kim JH, Jung PE. The Antiobese Effects of Gamikwakhyangjungkisan and Fermented Gamikwakhyangjungkisan in Preadipocytes and Mice Fed High Fat Diet. J Pediatr Korean Med. 2015;29(2):37-48. https://doi.org/10.7778/jpkm.2015.29.2.037
  21. Youn JD, Choi YH. Anti-Obesity Effect of Herbal Mixture Powder and Water Extract in Mice Fed a High Fat Diet. J of Society of Preventive Korean Medicine. 2015;19(1): 131-44.
  22. Le MD, Jung PE. The Effects of Dai-saiko-to(Da-Chai-Hu-Tang) on 3T3-L1 Preadipocytes and High-Fat Diet-Induced Obese Mice. J Pediatr Korean Med. 2015;29(1): 1-14.
  23. Keum SO, Lee HI, Lee JH, Yoon YI, Kwon YM, Song YS. Effects of Gami-Cheongpyesagan-Tang on Body Fat in High Fat Diet-Fed Obese Mice. J Korean Med Obes Res. 2015;15(1):75-92. https://doi.org/10.15429/jkomor.2015.15.2.75
  24. Kee YB, Kim DH, Yang MS, Kang DH, Kim SJ, Choi JB. Effect of Mixed Extract of Ephedrae Sinica and Fibrosum Gypsum on Differentiation of Preadipocytes and Obesity of Rats. J of Korean Medicine Rehabilitation. 2014;24(3): 11-27.
  25. Lee H, Park WH, Cha YY. Effects of Cheunggihwadamhwan Extract on Lowering Lipid, Antioxidation and Production of Proinflammatory Cytokines in Rats Fed on High Fat Diet. J of Korean Medicine Rehabilitation. 2014; 24(2):1-13.
  26. Seok HJ, Yoo JS, Ku JR, Yoon KH, Jo JH, Jang DH et al. Comparison of Gangjihwan Combination of Gangjihwan and Gamisochehwan in the Improvement Effects of Weight Loss in a High Fat Diet-Fed Obese Mice. Herbal Formula Science. 2014;22(2):105-20.
  27. Kim BC, Seok HJ, Yoo JS, Ku JR, Yoon KH, Jo JH et al. Comparison of Pakistani Ephedra Herba and Chinese Ephedra Herba Contaning Gangjihwan in the Improvement Effects of Weight Loss in a High Fat Diet-Fed Obese Mice. Herbal Formula Science.
  28. Shin YS, Hwang GS. The effects of Pueraria lobata extract on gene expression in liver tissue of rat with estrogen-deficient obesity. J of Society of Preventive Korean Medicine. 2014;18(3):117-28.
  29. Kang YM, Kim SH, Lee YC, Kim HK, Kim DS. Synergistic combination effect of anti-obesity in the extracts of Phyllostachys pubescence Mael and Scutellaria baicalensis Georgi. Kor J Herbology. 2014;29(6):7-13.
  30. Ha TH, Kwon TW, Kim YK. Effects of Ephedra Herba ethyl-acetate fraction on high fat diet induced hyperlipidemic mice. J of Society of Precentive Korean Medicine. 2014;18(2):101-13.
  31. Lee JY, Kook YB. Effects of Samhwangsasim-tang on obesity related metabolic disease in mice. Herbal Formula Science. 2014;22(1):93-104. https://doi.org/10.14374/HFS.2014.22.1.093
  32. Yoon YS, Keum SO, Lee SW, Kim IH, Lee HI, Song YS. Effects of Cheongshimyeonja-tang on the Body Weight and Serum Lipid Levels in High Fat Diet Induced Obese Mice. Herbal Formula Science. 2014;22(1):123-39. https://doi.org/10.14374/HFS.2014.22.1.123
  33. Shin SS, Yoon MC, Tsung PC, Lee YT. Gambigyeongsinhwan(1) Improves Body Weight and Lipid Metabolism in High Fat Diet-Fed Obese Animal Model. Kor J Herbology. 2014;29(1):35-43.
  34. Heo SK, Park WH, Cha YY. Effects of Jengjengamiyijin-tang (zhengzhuanjiaweierchentang) on Lowering Lipid, Antioxidation and Production of Inflammatory Mediators Being Used Rats Fed on High Oxidized Fat. Kournal of Korean Medicine Rehabilitation. 2013;23(4): 9-21.
  35. Chun JM, Kim DS, Choi GY, Sung YY, Park SH, Kim SH et al. Anti-obesity Effect of Five Formulas Which can be used to Treat Hypertension in High Fat Diet Induced Obese Mice. Korean J Oriental Physiology & Pathology. 2013;27(5):637-43.
  36. Chun JM, Choi GY, Kim DS, Sung YY, Nho KJ, Kim SH et al. The Anti-obesity Effect of 5 Herbal Formulas in High Fat Diet Induced Obese Mice. Herbal Formula Science. 2013;21(2):44-52. https://doi.org/10.14374/HFS.2013.21.2.044
  37. Kim TW, Kang SB. Antiobese and Antidiabetic Effects of Yookmijihwang-tang-gamibang, a Traditional Polyherbal Formula on the Obese and Type II Diabetic C57BL/6JHam-ob/ob Mice. Herbal Formula Science. 2013;21(2): 110-20. https://doi.org/10.14374/HFS.2013.21.2.110
  38. Park JI, Kang KH, Park EJ. The Study of Anti-obesity Effects of Mulberry Leaves Contained Herbal Mixture. J Pediatr Korean Med. 2013;27(4):17-30. https://doi.org/10.7778/jpkm.2013.27.4.017
  39. Chang SJ, Min DL, Park EJ. The Study of Anti-obesity Effects of Gamiygin-tang Extract and Ferment. J Pediatr Korean Med. 2013;27(4):108-21. https://doi.org/10.7778/jpkm.2013.27.4.108
  40. Song MY, Bose S, Kim HJ. Anti-Obesity Effects of Fermented Samjung-hwan in Hign Fat Diet Rats. J Korean Med Obes Res. 2013;13(1):17-23.
  41. Jeong HS. Efficacy of Alismatis Orientale Rhizoma on Obesity induced by High Fat Diet. Kor J Herbology. 2013;28(3):95-106.
  42. Kwon OJ, Lee SW, Paik SH, Han SR, Ahn YM, Ahn SY et al. The Effects Platycodi Radix on Obese Type 2 Diabetes Mouse Model Induced by High Fat, High Carbohydrate Diet. J Korean Oriental Med. 2013;34(1): 1-14.
  43. Oh SW, Kim BW. Effects of Jowiseungcheung-tang Extract on the Lipid Metabolism, Anti-oxidation and Inflammatory Reflex High Fat Diet Obese Rats. Korean J Orient Int Med. 2013:34(1);1-13.
  44. Lee HR, Ahn YJ, Lee HY, Lee HH, Kim DY, Yoon MC et al. Gambigyeongsinhwan(4) Reduces Body Weight and Hepatic Lipid Accumulation in High Fat Diet-Fed Obese Male C57BL/6N Mice. Korean J Oriental Physiology & Pathology. 2013;27(1):99-106.
  45. Kang IS, Hwang KY, Choi AY, Roh KW, Choi JH, Sim YM et al. Anti-obesity effects of herbal extract YY312 in C57BL/6 mice fed a high-fat diet and 3T3-L1 cells. Kor J Herbology. 2013;28(1):23-31. https://doi.org/10.6116/kjh.2013.28.1.23
  46. Hwang JS, Suk JM, Choi HM, Shin IS, Hwang SJ, Park JY et al. Effects of Plantaginis Semen & Poria (CJB) Water Extracts on Histomorphometrical Aspects and Histopathological Changes in High Fat Diet-induced Obese Rats. Kor J Herbology. 2013;28(1):91-6. https://doi.org/10.6116/kjh.2013.28.1.91
  47. Park KM, Lim HH, Song YK. Anti-inflammation and Anti-obesity Effects of Euiiin-tang Granules on High Fat Diet-Induced Obese C57BL/6J Mice. J Oriental Rehab Med. 2012;22(2):47-66.
  48. Choi SW, Kim DH, Choi SB, Park GH, Kim YS. The Effects of Salvia miltiorrhiza on Hig Fat Diet-induced Obese Diabetic Mouse Model. Korean J Orient Int Med. 2012;33(4):429-37.
  49. Paik SH, Han SR, Kwon OJ, Ahn YM, Ahn SY, Lee BC. The Effects in Metabolism and Adipose Tissue Inflammation Induced by the Massa Medicata Fermentata on Obese Type 2 Diabetes Mouse Model. J Korean Oriental Med. 2012;33(3):33-45.
  50. Han SR, Paik SH, Kwon OJ, Ahn YM, Lee BC, Ahn SY. Effects in Metabolism and Adipocyte Inflammation Induced by the Complex Herbal Medicine composed of Cornus officinalis, Dioscorea rhizoma, Aurantii fructus, Mori folium in Obese Type 2 Diabetes Mouse Model. J Korean Oreintal Med. 2012;33(3):184-99.
  51. Kim WI, Youn DH, Kim HG, Na CS. Effects of pear extracts containing herbal medicine(Lycii Fructus, Coicis Semen, Alimatis Rhizoma and Astragali Radix) on body weight, lipid metabolism and immune responses in rats fed high fat diets (II). Kor J Herbology. 2012;27(5):1-7.
  52. Lee JS, Noh HI, Yoon DR, Yi SR, Lew JH. Histological and Serological anti-Obesity Effects of Mori Folium in Obesity Induced SD Rat by High Fat Diet. Korean J Orient Int Med. 2012;33(3):306-16.
  53. Hwang JS, Suk JM, Choi HM, Shin IS, Hwang SJ, Park JY et al. Effects of CHB Water Extract on Obesity-Related Factors in Hypothalamus of Rats Fed High-Fat Diet. Kor J Herbology. 2012;27(5):99-107.
  54. Shin HJ, Yoo JE, Jung EH, Yoo DY. Effects of Pueraria lobata on Body Weight and Gene Expression in Obese Rats Muscle with Estrogen Deficiency. The J of Orient Obstetrics & Gynecology. 2012;25(3):71-84.
  55. Kim TH, Kim HI, Lee KG, Lee SR, Lee CH. Effects of Banggihwanggi-Tang on Obesity-related Enteroendocrine Cells and Neuropeptides in Mice. Korean J Oriental Physiology & Pathology. 2012;26(4):497-505.
  56. Shin IS, Choi HM, Ku SK, Kim MR. The Effects of Natural Mixture Supplementation on Histopathological and Histomorphometrical aspects in High Fat Diet-induced Obese Mice. Kor J Herbology. 2012;27(4):53-8.
  57. Yang SY, Lee HY, Lee HR, Kim BC, Park SI, Ahn YJ et al. Injecheonggeumdan reduces body weight gain and blood lipid profiles in gih fat diet-fed mice. The Korean J of Oriental Medical Prescription. 2012;20(1):67-80.
  58. Kim WI, Youn DH, Kim HG, Na CS. Effects of Pear Extracts Containing Herbal Medicine(Lycii Fructus, Coicis Semen, Alimatis Rhizoma and Astragali Radix) on Body Weight, Lipid Metabolism and Immune Responses of Rats Fed High Fat Diets (I). Kor J Herbology. 2012; 27(3):7-13.
  59. Kim TH, Lee CH. Effects of Mahangeuigan-Tang on Obesity-related Factors in Brain and Gastrointestinal Tract of Mice. Korean J Oriental Physiology & Pathology. 2012;26(2):166-74.
  60. Kong IP, Park WH, Cha YY. Effects of Ojeoksangamibang on the Lipid Metabolism, Anti-oxidation and Concentration of Proinflammatory Cytokines in Rat Fed High Fat Diet. J Oriental Rehab Med. 2011;21(4):23-40.
  61. Park JH, Hong SY. Anti-obesity Effects of Wolbi-tang on the Obese-mice Induced by High-fat Diet. J Oriental Rehab Med. 2011;21(2):31-48.
  62. An JR, Kang YK, Chang DH, Lee IS, Shin SS, Jeong HG et al. WBCEx1 Reduces Feeding Efficiency Ratio and Visceral Obesity in Obese Mice Induced by High Fat Diet. J Oriental Rehab Med. 2011;21(1):1-22.
  63. Song SY, Ahn SY, Ahn YM, Um JY, Jang HJ, Lee BC. Anti-Glycemic and Anti-Lipid Effects of Ethanol Extract of Supungsunkihwan-gagambang in High Fat Diet-induced Obese Mice. J Korean Oriental Med. 2011;32(5):1-11.
  64. Park EY, Ahn SY, Ahn YM, Um JY, Jang HJ, Lee BC. The Effects of Supungsunki-hwan Partitioned Prescriptions on Obese Type 2 Diabetes Mouse Model Induced by High Fat, High Carbohydrate Diet. Korean J Orient Int Med. 2011;32(3):387-96.
  65. Lee MJ, Yang GE, Lee JS, Noh HI, Yoon DR, An SM, Lew JH. Effects of Choweseungcheng-tang on Obesity and Hyperlipidemia in High-fat-diet-induced Obese Mice. J Korean Oriental Med. 2011;32(4):37-47.
  66. Park SW, Cho CS, Kim CJ. Effect of Yagwan-cheunghyeoltang on Obesity in Rats Induced by High Fat Diet. Korean J Orient Int Med. 2011;32(2):170-87.
  67. Park KJ, Lee HY, Lee HR, Yoon MC, Park SD, Lee YT et al. Ethyl acetate fraction of GGEx18 modulates feeding efficiency ratio and blood leptin level in high fat diet-fed obese mice. The Korean J of Oriental Medical Prescription. 2011;19(1):219-31.
  68. Lee HY, Yoon KH, Seo BI, Park GR, Yoon MC, Shen ZB et al. Molecular biologic mechanism of obesity by GGEx18. Kor J Herbology. 2011;26(1):65-74.
  69. Song HN, Lee HH, Kim JB. Effects of Water Extract of Yukeuigambi-tang on Obesity and Hyperlipidemia in Mice Induced by High Fat Diet. Korean J Oriental Physiology & Pathology. 2011;25(6):1026-31.
  70. Shin SS, Lee HY, Lee HR, Yoon MC, Lee YT. Gambigyeonogsinhwan(2) Reduces Blood Triglyceride Levels and Improves Visceral Fat in High Fat Diet-Fed Obese Male C57BL/6N Mice. The Korean J of Oriental Medical Prescription. 2011;19(2):47-59.
  71. Park IS, Yoon IJ. The Inhibitory Effects of So-yangin Biman-bang on the Obese-Mice Induced by High-Fat Diet. J Oriental Rehab Med. 2010;20(2):35-50.
  72. Tsung PC, Lee HY, Lee HR, Jeong HG, Yin YM, Yoon MC et al. Fermented Soybean Powder Reduces Body Weight Gain and Improves Hepatic Lipid Accumulation in High Fat Diet-Fed Obese Male C57BL/6N Mice. The Korean J of Oriental Medical Prescription. 2010;18(2): 201-13.
  73. Kim BK, Oh YJ, Chun YH, Ha JW, Lee HY, Jeong HG et al. Effects of SSEx on the Metabolic Syndrome in High-Fat Diet Induced Obese Mice. J of Oriental Neuropsychiatry. 2010;21(4):53-68.
  74. Hwang JP, Yoon IJ. The Anti-obesity Effects of Gambibang 4 on Obesity-induced Mice. J Korean Oriental Med. 2010;31(1):30-46.
  75. Park SM, Kim DS, Kang SA, Lee JB. Anti-obesity Effects and Mechanism of Original and Modified Gambejaeseup-tang in Female Rats with Diet-induced Obesity. Korean J Oriental Physiology & Pathology. 2010;24(4): 646-52.
  76. Hsiao MH, Ko SG, Jun CY, Park JH, Choi YK. Effects of Taeumjowe-tang-gagambang on the Glycometabolism and Lipidmetabolism in the Liver Tissue of Diet-induced Obesity Mice. Korean J Oriental Physiology & Pathology. 2010;24(4):638-45.
  77. Yoon KH, Lee HY, Jung YS, Seo BI, Park GR, Yoon MC et al. Modulation of obesity by Gyeongshingangjeehwan18 in ob/ob mice. Kor J Herbology. 2010;25(3):1-9.
  78. Yang DH, Kim CH, Jung JG, Jung HW, Choi CH. The Effects of Taeyeumjowee-tang and Taeyeumjoweebaemahwang-tang on Obese rats. Kor J Herbology. 2010; 25(3):103-9.
  79. Jang DY. Textbook of Obesity and body contouring. Seoul:MD world medical book co Ltd. 2011;35-107.
  80. George A Bray. Office management of Obesity. Philadelphia: Saunders. 2004;35-59, 108-25.
  81. Park YW. Evidence Based Formulas Composed of Health/Functional Foods to Control Weight. Korean J Fam med. 2003;24(5):409-15.
  82. Park CY. The Update of Anti-Obesity Drug. Kyung Hee Medicine. 2002;18(2):77-85.
  83. 韓醫科大學 本草學 編纂委員會. 本草學. Seoul:永林社. 2004;154-6, 201-3.
  84. Jang IS, Yang CS, Hwang EH. The Need for Clinical Practice Guidelines in Usage of Mahuang in Weight Loss. J Korean Med Obes Res. 2007;7(1):23-9.
  85. Kim HJ, Han CH, Lee EJ, Song YK, Shin BC, Kim YK. A Clinical Practice Guideline for Ma-huang(Ephedra sinica) Prescription in Obesity. J Korean Med Obes Res. 2007; 7(2):27-7.
  86. Song MY, Kim HJ, Lee MJ. The Safety Guidelines for use of Ma-huang in Obesity Treatment. J Korean Med Obes Res. 2006;6(2):17-27.