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Effect of Gd-EOB-DTPA on Hepatic Fat Quantification using Two-point Dixon Technique

Two-point Dixon기법을 이용한 간의 지방정량화에 Gd-EOB-DTPA가 미치는 영향

  • 구노현 (서울아산병원 영상의학과) ;
  • 최관우 (서울아산병원 영상의학과) ;
  • 유병규 (원광보건대학교 방사선과)
  • Received : 2017.04.04
  • Accepted : 2017.05.04
  • Published : 2017.07.28

Abstract

The purpose of present study was to assess whether Gd-EOB-DTPA with gadolinium-based contrast agent administration affects fat quantification using the two-point Dixon technique. Between April 2016 and September, 60 patients who underwent hepatic fat quantification using the two-point Dixon technique were divided into two group (normal liver donors=30, abnormal hepatic steatosis=30) and we compared the variability of mean fat fraction before and after administration Gd-EOB-DTPA. As a results, in both group, fat fraction after injection Gd-EOB-DTPA was significantly decreased (normal liver donors -33.8%, hepatic steatosis -47.2%) compared to before injection Gd-EOB-DTPA, suggesting that Gd-EOB-DTPA affects fat quatification using two-point Dixon technique. In conclusion, hepatic fat quantification using the two-point Dixon technique could maintain diagnostic value by acquiring images before administration Gd-EOB-DTPA.

Keywords

Fat Quantification;Two-point Dixon;Hepatic Steatosis

Acknowledgement

Supported by : 원광보건대학교

References

  1. H. Yu, C. A. McKenzie, and A. Shimakawa, "Multiecho reconstruction for simultaneous water-fat decomposition and T2* estimation," J Magn Reson Imaging, Vol.26, No.4, pp.1153-1161, 2007. https://doi.org/10.1002/jmri.21090
  2. C. A. Matteoni, Z. M. Younossi, T. Gramlich, N. Boparai, Y. C. Liu, and A. J. McCullough, "Nonalcoholic fatty liver disease:a spectrum of clinical and pathological severity," Gastroenterology, Vol.116, No.6, pp.1413-1419, 1999. https://doi.org/10.1016/S0016-5085(99)70506-8
  3. V. Ratziu, F. Charlotte, and A. Heurtier, "Sampling variability of liver biopsy in nonalcoholic fatty liver disease," Gastroenterology, Vol.128, No.7, pp.1898-1906, 2005. https://doi.org/10.1053/j.gastro.2005.03.084
  4. G. Mingmei, Z. Jing, W. Bing, L. Zhiqin, S. Hai, and M. Xiangfeng, "Effect of gadolinium on hepatic fat quantification using multi-echo reconstruction technique with T2* correction and estimation," Eur Radio, Vol.26, No.6, pp.1913-1920, 2016. https://doi.org/10.1007/s00330-015-3981-z
  5. T. Yokoo, M. Shiehmorteza, and G. Hamilton, "Estimation of hepatic proton-density fat fraction by using MR imaging at 3.0T," Radiology, Vol.258, No.3, pp.749-759, 2011. https://doi.org/10.1148/radiol.10100659
  6. W. T. Dixon, "Simple proton spectroscopic imaging," Radiology, Vol.159, No.1, pp.189-194, 1984.
  7. J. Ma, "Dixon techniques for water and fat imaging," J Magn Reson Imaging, Vol.28, No.3, pp.543-558, 2008. https://doi.org/10.1002/jmri.21492
  8. L. Filli, E. J. Ulbrich, R. Guggenberger, A. Boss, M. A. Fischer, F. G. Del, B. Maurer, and G. Andreisek, "Effect of Gd-DOTA on fat quantification in skeletal muscle using two-point Dixon technique - preliminary data," Eur J Radiol, Vol.85, No.1, pp.131-135, 2016. https://doi.org/10.1016/j.ejrad.2015.11.007
  9. G. H. Glover and E. Schneider, "Three-point Dixon technique for true water/fat decomposition with B0 inhomogeneity correction," Magn Reson Med, Vol.18, No.2, pp.371-383, 1991. https://doi.org/10.1002/mrm.1910180211
  10. T. Yokoo, J. M. Collins, R. F. Hanna, M. Bydder, M. S. Middleton, and C. B. Sirlin, "Effects of intravenous gadolinium administration and flip angle on the assessment of liver fat signal fraction with opposed-phase and in-phase imaging," J Magn Reson Imaging, Vol.28, No.1, pp.246-251, 2008. https://doi.org/10.1002/jmri.21375
  11. J. Schelhorn, J. Best, A. Dechene, T. Gobel, S. Bertram, T. Lauenstein, and S. Kinner, "Evaluation of combined Gd-EOB-DTPA and gadobutrol magnetic resonance imaging for the prediction of hepatocellular carcinoma grading," Acta Radiol, Vol.57, No.8, pp.932-938, 2016. https://doi.org/10.1177/0284185115616293
  12. K. W. Choi1 and S. Y. Son, "An effectiveness of multitransmit parallel technique on scan time reduction in hip joint MRI," J. of Korea Academia-Industrial cooperation Society, Vol.17, No.3, pp.103-108, 2016.
  13. M. Dewey, T. Schink, and C. F. Dewey, "Claustrophobia during magnetic resonance imaging: cohort study in over 55,000 patients," J Magn Reson Imaging, Vol.26, No.5, pp.1322-1327, 2007. https://doi.org/10.1002/jmri.21147
  14. A, Pirasteh, H. R. Clark, E. A. Sorra 2nd, I. Pedrosa, and T. Yokoo, "Effect of steatosis on liver signal and enhancement on multiphasic contrast-enhanced magnetic resonance imaging," Abdom Radiol (NY), Vol.41, No.9, pp.1744-1750, 2016. https://doi.org/10.1007/s00261-016-0736-5
  15. M. R. Bashir, E. M. Merkle, A. D. Smith, and D. T. Boll, "Hepatic MR imaging for in vivo differentiation of steatosis, iron deposition and combined storage disorder: single-ratio in/opposed phase analysis vs. dual-ratio Dixon discrimination," Eur J Radiol, Vol.81, No.2, pp.e101-e109, 2012. https://doi.org/10.1016/j.ejrad.2011.01.067
  16. G. Hamilton, M. S. Middleton, G. M. Cunha, and C. B. Sirlin, "Effect of gadolinium-based contras agent on the relaxation properties of water and fat in human liver as measured in vivo by 1H MRS. Book of abstracts: 21th annual meeting of the International Society for Magnetic Resonance in Medicine," pp.15-16, 2013.
  17. Y. S. Park, C. H. Lee, J. H. Kim, B. H. Kim, J. H. Kim, K. A. Kim, and C. M. Park, "Effect of Gd-EOB-DTPA on hepatic fat quantification using high-speed T2-corrected multi-echo acquisition in (1)H MR spectroscopy," Magn Reson Imaging, Vol.32, No.7, pp.886-890, 2014. https://doi.org/10.1016/j.mri.2014.04.010
  18. M. S. Carrasco, B. C. Calles, J. Marcin, A. C. Fernandez, and M. J. Lafuente, "Gadolinium-based contrast agents for magnetic resonance imaging," Radiologia, Vol.56, No.1, pp.21-28, 2014. https://doi.org/10.1016/j.rx.2014.06.005
  19. M. H. Fishbein, K. G. Gardner, C. J. Potter, P. Schmalbrock, and M. A. Smith, "Introduction of fast MR imaging in the assessment of hepatic steatosis," Magn Reson Imaging, Vol.15, No.3, pp.287-293, 1997. https://doi.org/10.1016/S0730-725X(96)00224-X