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Association between the Polymorphism of Glutathione S-transferase Genes and Autoimmune Diseases in Asian Population: a Meta-analysis

아시아인종에서 자가면역질환과 GST 유전자 다형성의 메타분석

  • 김희성 (단국대학교 의과대학 제일병원 진단검사의학과)
  • Received : 2017.03.15
  • Accepted : 2017.05.02
  • Published : 2017.07.28

Abstract

To verify the association between GSTM1/GSTT1 gene polymorphisms and susceptibility to autoimmune diseases in Asian population. 18 published reports cited in EMBASE, Google, KISS, MEDLINE and PubMed up to December 2015 were collected for a meta-analysis. The GSTM1/GSTT1 polymorphism for null and present type were analysed separately. The significant association was found between the GST polymorphism and autoimmune diseases in an overall population (GSTM1, OR=1.334, 95% CI=1.137-1.567, p=0.000; GSTT1, OR=1.212, 95% CI=1.012-1.452, p=0.037). Asian population showed the significant association of GSTM1 in the autoimmune diseases, especially vitiligo and atopic dermatitis but non-significant association of GSTT1 in RA and SLE. The GSTM1 null and the GSTT1 present type showed the association with autoimmune diseases in Asian population. The null type frequency of the combination of GSTM1-GSTT1 polymorphism in autoimmune diseases in Asian population was higher than that of the control group. This result indicated that null type of GSTM1-GSTT1 combination can be a risk factor of autoimmune diseases in Asian population.

Keywords

Autoimmune Disease;Meta-analysis;Glutathione S-transferase;Gene Polymorphism

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