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Development of Biochip Sensors for Blood Biomarkers Specific to Alzheimer's Disease Diagnostics

알츠하이머 질병 진단을 위한 혈액 바이오마커 검출용 바이오칩 센서 개발

  • Kim, Suhee (Department of Chemistry and Green-Nano materials Research Center, Kyungpook National University) ;
  • Lee, Sang Hyuk (Department of Chemistry and Green-Nano materials Research Center, Kyungpook National University) ;
  • Lee, Hye Jin (Department of Chemistry and Green-Nano materials Research Center, Kyungpook National University)
  • 김수희 (경북대학교 자연과학대학 화학과 및 청정나노소재 연구소) ;
  • 이상혁 (경북대학교 자연과학대학 화학과 및 청정나노소재 연구소) ;
  • 이혜진 (경북대학교 자연과학대학 화학과 및 청정나노소재 연구소)
  • Received : 2017.07.15
  • Accepted : 2017.07.20
  • Published : 2017.08.10

Abstract

The number of patients suffering from Alzheimer's disease is increasing year after year and almost approaching 15% of the total elderly population. Although it is critical to detect the early stage of Alzheimer's disease, which is a serious illness causing cognitive deficits, various existing diagnosis methods such as MRI, PET and CSF analysis could be the burdens for patients due to their high costs and long time to diagnosis. In order to tackle some of challenging issues for such existing diagnosis methods, extensive efforts have been made on developing fast and convenient biochip sensing methodologies for the diagnosis of Alzheimer's disease with a droplet of patient biofluids (e.g., blood). In this mini-review, we highlight some of the latest biochip sensing technologies that could qualitatively and quantitatively analyze blood biomarkers used for Alzheimer's disease diagnostics and discuss briefly related research trends and future aspects.

Acknowledgement

Supported by : Kyungpook National University

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