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Antihypertensive effect of ethanol extracts of Aralia elata in spontaneously hypertensive rats

선천성 고혈압 흰쥐에서 두릅 에탄올 추출물의 항고혈압 효과

  • Jin, Ju-Youn (College of Veterinary Medicine, Jeju National University) ;
  • Park, Eun-Hye (College of Veterinary Medicine, Jeju National University) ;
  • Jeon, Yoon-A (College of Veterinary Medicine, Jeju National University) ;
  • Lee, Young-Jae (College of Veterinary Medicine, Jeju National University)
  • 진주연 (제주대학교 수의과대학) ;
  • 박은혜 (제주대학교 수의과대학) ;
  • 전윤아 (제주대학교 수의과대학) ;
  • 이영재 (제주대학교 수의과대학)
  • Received : 2017.05.04
  • Accepted : 2017.07.14
  • Published : 2017.09.30

Abstract

Antihypertensive effects of ethanol extracts of Aralia elata (Miq.) Seem. (AE) were investigated in spontaneously hypertensive rats (SHR). SHR aged 14 weeks were treated for 8 weeks with AE (10 or 50 mg/kg/day) or amlodipine besylate (Am; 10 mg/kg/day) orally. Hypertension results in injury to several organs and can produce a significant increase in malondialdehyde (MDA) content as a result of lipid peroxidation and endothelial dysfunction. In this study, oral administration of AE and Am significantly reduced systolic blood pressure, organ weight index, and MDA content in tissues but increased significantly the plasma nitrite and nitrate concentrations. The endothelium-dependent relaxant activities of acetylcholine ($10^{-10}-10^{-3}M$) in norepinephrine (NE)-precontracted aorta were increased in AE- and Am-treated rats. Particularly strong endothelium-dependent relaxant activities were observed in AE-treated (50 mg/kg) rats. The endothelium-independent relaxant activities of sodium nitroprusside ($10^{-10}-10^{-3}M$) in NE-precontracted aorta were not changed. The results of this study suggest that AE has both antihypertensive and end-organ protective effects in SHR.

Acknowledgement

Grant : 6개월 투여로 완치가 가능한 참두릅 유래 고혈압 개선제의 인체 적용 시험을 통한 개별 인정형 건강기능식품 제품화

Supported by : 중소기업기술정보진흥원

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