The influence and role of melatonin on in vitro oocyte maturation and embryonic development in pig and cattle

  • Lin, Tao (Division of Animal Science, Research Center for Transgenic Cloned Pigs, Chungnam National University) ;
  • Lee, Jae Eun (Division of Animal Science, Research Center for Transgenic Cloned Pigs, Chungnam National University) ;
  • Kang, Jeong Won (Division of Animal Science, Research Center for Transgenic Cloned Pigs, Chungnam National University) ;
  • Kim, So Yeon (Division of Animal Science, Research Center for Transgenic Cloned Pigs, Chungnam National University) ;
  • Jin, Dong Il (Division of Animal Science, Research Center for Transgenic Cloned Pigs, Chungnam National University)
  • Received : 2017.08.23
  • Accepted : 2017.09.25
  • Published : 2017.09.30


Melatonin (N-acetyl-5-methoxytryptamine) is an indole synthesized from tryptophan by the pineal gland in animal. The major function of melatonin is to modulate circadian and circannual rhythms in photoperiodic mammals. Importantly, however, melatonin is also a free radical scavenger, anti-oxidant, and anti-apoptotic agent. Recently, the beneficial effects of melatonin on oocyte maturation and embryonic development in vitro have been reported in many species such as pig, cattle, sheep, mouse, and human. In this review, we will discuss recent studies about the role of melatonin in the production of porcine and bovine oocytes and embryos in vitro in order to provide useful information of melatonin in oocyte maturation and embryo culture in vitro.


Supported by : Rural Development Administration


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