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Systematic Review on Traditional Chinese Herbal Medicine Treatment for Antibiotic Associated Diarrhea

항생제 연관성 설사의 중의약 치료 효과에 대한 체계적 고찰

  • Chang, Seju ;
  • Lee, Myeong-Jong ;
  • Kim, Hojun
  • 장세주 ;
  • 이명종 ;
  • 김호준
  • Received : 2017.09.14
  • Accepted : 2017.09.28
  • Published : 2017.10.31

Abstract

Objectives To summarize and evaluate the efficacy of traditional Chinese herbal medicine (TCHM) treatment for antibiotic associated diarrhea (AAD). Methods Eight electronic databases were searched from their inception to August 2017. Randomized controlled trials (RCTs) assessing the efficacy of TCHM treatment for AAD were included. The risk of bias was assessed using the Cochrane risk of bias assessment tool. Data analysis was performed using RevMan software version 5.3. Results Seventeen RCTs involving 1138 patients with AAD were included for qualitative synthesis. TCHM treatment improved total effective rate (TER). However, the results that TER in experimental group was significantly higher than in control group were different between the included studies. TCHM enema treatment improved TER, but not significantly higher than control group. The most frequently used herbal formulas were Gamiwekwanjeon, Gamiinsampaedoksan, and Samryungbaekchulsan. The most frequently used TCHMs were Atractylodes macrocephala (Bai Zhu), Dioscorea batatas (Shan Yao). Within the studies documenting the adverse events, no serious adverse events associated with TCHM treatment were observed. Conclusions Evidence of TCHM treatment efficacy for AAD is encouraging, but not conclusive, because of the low methodological qualities, diversity of TCHM treatment prescriptions. Further well-designed RCTs with rigorous randomization and blinding method are needed to confirm these results.

Keywords

Antibiotic associated diarrhea;Clostridium difficile;Herb;Traditional Chinese medicine

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Acknowledgement

Supported by : 한국연구재단