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Memory improvement effect of Artemisia argyi H. fermented with Monascus purpureus on streptozotocin-induced diabetic mice

스트렙토조토신으로 유도된 당뇨 마우스에서 Monascus purpureus을 이용한 발효 쑥의 기억력 개선 효과

  • Lee, Chang Jun (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Lee, Du Sang (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Kang, Jin Yong (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Kim, Jong Min (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Park, Seon Kyeong (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Kang, Jeong Eun (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Kwon, Bong Seok (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Park, Sang Hyun (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Park, Su Bin (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Ha, Gi-Jeong (Gyeongsangnamdo Agricultural Research and Extension Service) ;
  • Heo, Ho Jin (Division of Applied Life Science (BK21 plus), Institute of Agriculture and Life Science, Gyeongsang National University)
  • 이창준 (경상대학교 응용생명과학부(BK21 plus), 농업생명과학연구원) ;
  • 이두상 (경상대학교 응용생명과학부(BK21 plus), 농업생명과학연구원) ;
  • 강진용 (경상대학교 응용생명과학부(BK21 plus), 농업생명과학연구원) ;
  • 김종민 (경상대학교 응용생명과학부(BK21 plus), 농업생명과학연구원) ;
  • 박선경 (경상대학교 응용생명과학부(BK21 plus), 농업생명과학연구원) ;
  • 강정은 (경상대학교 응용생명과학부(BK21 plus), 농업생명과학연구원) ;
  • 권봉석 (경상대학교 응용생명과학부(BK21 plus), 농업생명과학연구원) ;
  • 박상현 (경상대학교 응용생명과학부(BK21 plus), 농업생명과학연구원) ;
  • 박수빈 (경상대학교 응용생명과학부(BK21 plus), 농업생명과학연구원) ;
  • 하기정 (경상남도농업기술원) ;
  • 허호진 (경상대학교 응용생명과학부(BK21 plus), 농업생명과학연구원)
  • Received : 2017.05.30
  • Accepted : 2017.07.06
  • Published : 2017.10.31

Abstract

The effect of Artemisia argyi H. under liquid-state fermentation by Monascus purpureus (AAFM) on cognitive impairments has been studied in a mice model of diabetes-associated cognitive decline induced by streptozotocin (STZ). C57BL/6 mice (9 weeks of age, male) were separated into four groups: a normal control, STZ-induced diabetic mouse group (STZ group), Artemisia argyi H. (AA) 10 group (diabetic mouse+AA 10 mg/kg/day), AAFM 10 group (diabetic mouse+AAFM 10 mg/kg/day). Administration of AA and AAFM significantly improved glucose tolerance, as shown by the intraperitoneal glucose tolerance test (IPGTT), and ameliorated cognitive deficit, as shown by the behavioral tests including passive avoidance, Morris water maze, and Y-maze tests. After behavioral tests, the cholinergic system was examined by assessment of the acetylcholine (ACh) level and acetylcholinesterase (AChE) inhibitory activity, and the antioxidant system was also assessed by measuring malondialdehyde (MDA) and superoxide dismutase (SOD) levels in the brain and liver.

Keywords

Artemisia argyi H.;Monascus purpureus;streptozotocin;diabetic mouse;cognitive function

Acknowledgement

Supported by : 농촌진흥청

References

  1. DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM: A balanced overview. Diabetes Care 15: 318-368 (1992) https://doi.org/10.2337/diacare.15.3.318
  2. Vlassara H, Uribarri J. Advanced glycation end products (AGE) and diabetes: Cause, effect, or both? Curr. Diabetes Rep. 14: 453-462 (2014) https://doi.org/10.1007/s11892-013-0453-1
  3. Beauquis J, Roig P, Homo-Delarche F, De Nicola A, Saravia F. Reduced hippocampal neurogenesis and number of hilar neurones in streptozotocin-induced diabetic mice: Reversion by antidepressant treatment. Eur. J. Neurosci. 23: 1539-1546 (2006) https://doi.org/10.1111/j.1460-9568.2006.04691.x
  4. Bossy-Wetzel E, Barsoum MJ, Godzik A, Schwarzenbacher R, Lipton SA. Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr. Opin. Cell Biol. 15: 706-716 (2003) https://doi.org/10.1016/j.ceb.2003.10.015
  5. Bidchol AM, Wilfred A, Abhijna P, Harish R. Free radical scavenging activity of aqueous and ethanolic extract of Brassica oleracea L. var. italica. Food Bioprocess Tech. 4: 1137-1143 (2011) https://doi.org/10.1007/s11947-009-0196-9
  6. Kim JH, Lee U, Heo HJ. Ameliorating effect of water extract from Dendropanax morbifera Lev. on memory dysfunction in streptozotocin-induced diabetic rats. Korean J. Food Sci. Technol. 48: 275-283 (2016) https://doi.org/10.9721/KJFST.2016.48.3.275
  7. Hayashi K, Kojima R, Ito M. Strain differences in the diabetogenicactivity of streptozotocin in mice. Biol. Pharm. Bull. 29:1110-1119 (2006) https://doi.org/10.1248/bpb.29.1110
  8. Kim RJ, Kang MJ, Hwang CR, Jung WJ, Shin JH. Antioxidant and cancer cell growth inhibition activity of five different varieties of Artemisia cultivars in Korea. J. Life Sci. 22: 844-851 (2012) https://doi.org/10.5352/JLS.2012.22.6.844
  9. Ha GJ, Lee DS, Seung TW, Park CH, Park SK, Jin DE, Heo HJ. Anti-amnesic and neuroprotective effects of Artemisia argyi H. (Seomae mugwort) extracts. Korean J. Food Sci. Technol. 47: 380-387 (2015) https://doi.org/10.9721/KJFST.2015.47.3.380
  10. Park E, Kwon BM, Jung IK, Kim JH. Hypoglycemic and antioxidant effects of jaceosidin in streptozotocin-induced diabetic mice. J. Nutr. Health 47: 313-320 (2014) https://doi.org/10.4163/jnh.2014.47.5.313
  11. Shi YC, Liao JW, Pan TM. Antihypertriglyceridemia and antiinflammatory activities of Monascus-fermented dioscorea in streptozotocin-induced diabetic rats. Exp. Diabetes Res. 2011: 710635 (2011)
  12. Cha JY, Park JC, Ahn HY, Eom KE, Park BK, Jun BS, Cho YS. Effect of Monascus purpureus-fermented Korean red ginseng powder on the serum lipid levels and antioxidative activity in rats. J. Korean Soc. Food Sci. Nutr. 38: 1153-1160 (2009) https://doi.org/10.3746/jkfn.2009.38.9.1153
  13. Kang MR, Kim JY, Hyun YJ, Kim HJ, Yeo HY, Song YD, Lee JH. The effect of red-yeast-rice supplement on serum lipid profile and glucose control in subjects with impaired fasting glucose or impaired glucose tolerance. Korean J. Nutr. 41: 31-40 (2008)
  14. Kang SA, Kwoun SJ, Choi YS, Lim Y, Park DK. The effects of monacolin-inoculated rice embryo on the body fat and serum lipid profiles of obese elementary school students. Korean J. Community Nutr. 10: 565-573 (2005)
  15. Pyo YH. Effect of Monascus-fermentation on the content of GABA and free amino acids in soybean. J. Korean Soc. Food Sci. Nutr. 37: 1208-1213 (2008) https://doi.org/10.3746/jkfn.2008.37.9.1208
  16. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11: 47-60 (1984) https://doi.org/10.1016/0165-0270(84)90007-4
  17. Verbeek J, Spincemaille P, Vanhorebeek I, van den Berghe G, Vander Elst I, Windmolders P, Cammue B. Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice. Lipids Health Dis. 16: 46-55 (2017) https://doi.org/10.1186/s12944-017-0432-7
  18. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18: 499-502 (1972)
  19. Vincent A, Newsom-Davis J. Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays. J. Neurol. Neurosur. Ps. 83: 237-238 (2012) https://doi.org/10.1136/jnnp-2011-301046
  20. Park SA, Kim MJ, Jang JY, Choi MS, Yeo J, Lee MK. Effect of genistein and daidzein on antioxidant defense system in C57-BL/KsJ-db/db mice. J. Korean Soc. Food Sci. Nutr. 35: 1159-1165 (2006) https://doi.org/10.3746/jkfn.2006.35.9.1159
  21. Chang JC, Wu MC, Liu IM, Cheng JT. Plasma glucose-lowering action of Hon-Chi in streptozotocin-induced diabetes rat. Horm. Metab. Res. 38: 76-81 (2006) https://doi.org/10.1055/s-2006-925116
  22. Schmatz R, Mazzanti CM, Spanevello R, Stefanello N, Gutierres J, Corra M, da Rosa MM, Rubin MA, Schetinger MRC, Morsch VM. Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 610: 42-48 (2009) https://doi.org/10.1016/j.ejphar.2009.03.032
  23. Nitta A, Murai R, Suzuki N, Ito H, Nomoto H, Katoh G, Furukawa S. Diabetic neuropathies in brain are induced by deficiency of BDNF. Neurotoxicol. Teratol. 24: 695-701 (2002) https://doi.org/10.1016/S0892-0362(02)00220-9
  24. Bellush LL, Reid SG, North D. The functional significance of biochemical alterations in streptozotocin-induced diabetes. Physiol. Behav. 50: 973-981 (1991) https://doi.org/10.1016/0031-9384(91)90424-M
  25. Kuhad A, Sethi R, Chopra K. Lycopene attenuates diabetes-associated cognitive decline in rats. Life Sci. 83: 128-134 (2008) https://doi.org/10.1016/j.lfs.2008.05.013
  26. Ha GJ, Jeong CH, Jeong HR, Heo HJ, Shon GM, Rho CW, Kim NK. Antioxidant activities from the different parts of Artemisia argyi H. using an in vitro system. J. Agr. Life Sci. 45: 109-117 (2011)
  27. Won HJ, Lee HS, Kim JT, Hong CO, Koo YC, Lee KW. The anti-diabetic effects of kocat-d1 on streptozotocin-induced diabetic rats. Korean J. Food Sci. Technol. 42: 204-209 (2010)
  28. Jung UJ, Park YB, Kim SR, Choi MS. Supplementation of persimmon leaf ameliorates hyperglycemia, dyslipidemia and hepatic fat accumulation in type 2 diabetic mice. PloS one 7: e49030 (2012) https://doi.org/10.1371/journal.pone.0049030
  29. Paolisso G, Barbagallo M, Petrella G, Ragno E, Barbieri M, Giordano M, Varricchio M. Effects of simvastatin and atorvastatin administration on insulin resistance and respiratory quotient in aged dyslipidemic non-insulin dependent diabetic patients. Atherosclerosis 150: 121-127 (2000) https://doi.org/10.1016/S0021-9150(99)00352-4
  30. Pontrelli L, Parris W, Adeli K, Cheung RC. Atorvastatin treatment beneficially alters the lipoprotein profile and increases lowdensity lipoprotein particle diameter in patients with combined dyslipidemia and impaired fasting glucose/type 2 diabetes. Metabolism 51: 334-342 (2002) https://doi.org/10.1053/meta.2002.30510
  31. Han HK, Je HS, Kim GH. Effects of Cirsium japonicum powder on plasma glucose and lipid level in streptozotocin induced diabetic rats. Korean J. Food Sci. Technol. 42: 343-349 (2010)
  32. Ghareeb DA, Hussen HM. Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats. Neurosci. Lett. 436: 44-47 (2008) https://doi.org/10.1016/j.neulet.2008.02.073
  33. Biessels GJ, Deary IJ, Ryan CM. Cognition and diabetes: A lifespan perspective. Lancet Neurol. 7: 184-190 (2008) https://doi.org/10.1016/S1474-4422(08)70021-8
  34. Sohn MK, Shin YW. A comparative study of memory improving effects of Taraxaci Herba on scopolamine-induced amnesia in mouse. Korea J. Herbol. 27: 27-35 (2012)
  35. Baynes W. Chemical modification of proteins by lipids in diabetes. Clin. Chem. Lab. Med. 41: 1159-1165 (2003)
  36. Putt DA, Zhong Q, Lash LH. Adaptive changes in renal mitochondrial redox status in diabetic nephropathy. Toxicol. Appl. Pharm. 258: 188-198 (2012) https://doi.org/10.1016/j.taap.2011.10.021
  37. Stoewsand GS. Bioactive organosulfur phytochemicals in Brassica oleracea vegetables. Food Chem. Toxicol. 33: 537-543 (1995) https://doi.org/10.1016/0278-6915(95)00017-V
  38. Zhao B. Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease. Neurochem. Res. 34: 630-638 (2009) https://doi.org/10.1007/s11064-008-9900-9
  39. Mohan-Kumari HP, Dhale MA, Akhilender Naidu K, Vijayalakshmi G. Antioxidant effect of red mould rice in hypercholesterolemic Wistar male rats. Cell Biochem. Funct. 29: 597-602 (2011) https://doi.org/10.1002/cbf.1793