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Impact of Cassia acutifolia Infusion on Glucose Levels in Obesity and Diabetes Rat Model

  • Raffoul-Orozco, Abdel Kerim (Institute of Experimental and Clinical Therapeutics, Department of Physiology, Health Sciences University Center, University of Guadalajara) ;
  • Avila-Gonzalez, Ana Elisa (Institute of Experimental and Clinical Therapeutics, Department of Physiology, Health Sciences University Center, University of Guadalajara) ;
  • Barajas-Vega, Jessica Lucia (Institute of Experimental and Clinical Therapeutics, Department of Physiology, Health Sciences University Center, University of Guadalajara) ;
  • Rodriguez-Razon, Christian Martin (Laboratory Immunology, Department of Physiology, Health Sciences University Center, University of Guadalajara) ;
  • Garcia-Cobian, Teresa Arcelia (Institute of Experimental and Clinical Therapeutics, Department of Physiology, Health Sciences University Center, University of Guadalajara) ;
  • Ramirez-Lizardo, Ernesto Javier (Institute of Experimental and Clinical Therapeutics, Department of Physiology, Health Sciences University Center, University of Guadalajara) ;
  • Rubio Arellano, Edy David (Laboratory Pharmaceutical Research and Development, Department of Pharmacobiology, Exact Sciences and Engineering Center, University of Guadalajar)
  • Received : 2017.05.18
  • Accepted : 2017.09.12
  • Published : 2017.09.30

Abstract

Objectives: The aim of this study was to investigate the effects of Cassia acutifolia on the obesity and the glucose levels in a rat model of obesity and diabetes. Methods: By random selection, 36 Wistar male rats were divided in two control groups, the positive and the negative control groups, and into four experimental groups receiving different infusions of Cassia acutifolia in water ad libitum. Results: The results revealed a statistically significant anti-obesogenic effect (P = 0.02), although this was not considered clinically significant. Additionally, Cassia acutifolia lowered the glucose levels by 30 mg/dL to 90 mg/dL (P = 0.05). However, we observed adverse effects in the liver, a two-fold increase in transaminase levels (P = 0.002), and in the kidneys, decreased creatinine levels (P = 0.001), and these adverse effects had no viable explanation. Conclusion: Cassia acutifolia has anti-hyperglycemic effects in obese diabetic rats. However, Cassia acutifolia also has adverse effects, so it should not be administered to patients.

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