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Genome scan linkage analysis identifies a major quantitative trait loci for fatty acid composition in longissimus dorsi muscle in an F2 intercross between Landrace and Korean native pigs

  • Park, Hee-Bok (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration) ;
  • Han, Sang-Hyun (Educational Science Research Institute, Jeju National University) ;
  • Yoo, Chae-Kyoung (Institute of Agriculture and Life Sciences, Gyeongsang National University) ;
  • Lee, Jae-Bong (Korea Zoonosis Research Institute, Chonbuk National University) ;
  • Kim, Ji-Hyang (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration) ;
  • Baek, Kwang-Soo (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration) ;
  • Son, Jun-Kyu (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration) ;
  • Shin, Sang-Min (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration) ;
  • Lim, Hyun-Tae (Institute of Agriculture and Life Sciences, Gyeongsang National University) ;
  • Cho, In-Cheol (Subtropical Livestock Research Institute, National Institute of Animal Science, Rural Development Administration)
  • Received : 2016.07.22
  • Accepted : 2016.12.29
  • Published : 2017.08.01

Abstract

Objective: This study was conducted to locate quantitative trait loci (QTL) influencing fatty acid (FA) composition in a large $F_2$ intercross between Landrace and Korean native pigs. Methods: Eighteen FA composition traits were measured in more than 960 $F_2$ progeny. All experimental animals were genotyped with 165 microsatellite markers located throughout the pig autosomes. Results: We detected 112 QTLs for the FA composition; Forty seven QTLs reached the genome-wide significant threshold. In particular, we identified a cluster of highly significant QTLs for FA composition on SSC12. QTL for polyunsaturated fatty acid on pig chromosome 12 (F-value = 97.2 under additive and dominance model, nominal p-value $3.6{\times}10^{-39}$) accounted for 16.9% of phenotypic variance. In addition, four more QTLs for C18:1, C18:2, C20:4, and monounsaturated fatty acids on the similar position explained more than 10% of phenotypic variance. Conclusion: Our findings of a major QTL for FA composition presented here could provide helpful information to locate causative variants to improve meat quality traits in pigs.

Keywords

Fatty Acid;Quantitative Trait Locus;Genome-wide Linkage Analysis;Landrace;Korean Native Pigs

Acknowledgement

Supported by : National Institute of Animal Science

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