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Effects of proteinate complex zinc on growth performance, hepatic and splenic trace elements concentrations, antioxidative function and immune functions in weaned piglets

  • She, Yue (State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry Centre, ALLTECH-MAFIC Research Alliance, China Agricultural University) ;
  • Huang, Qiang (State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry Centre, ALLTECH-MAFIC Research Alliance, China Agricultural University) ;
  • Li, Defa (State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry Centre, ALLTECH-MAFIC Research Alliance, China Agricultural University) ;
  • Piao, Xiangshu (State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry Centre, ALLTECH-MAFIC Research Alliance, China Agricultural University)
  • Received : 2016.11.10
  • Accepted : 2017.01.09
  • Published : 2017.08.01

Abstract

Objective: To assess the effects of proteinate complex zinc (PC-Zn) on growth performance, antioxidative function, trace element concentrations and immune function in weaned piglets. Methods: Three hundred newly weaned barrows ($Duroc{\times}Landrace{\times}Yorkshire$), 28 days of age, were randomly allotted to 3 dietary groups of 5 replicate pens per group for 4 weeks of feeding. Experimental diets were: i) zinc deficient diet (ZnD, 24 mg/kg Zn supplementation from $ZnSO_4$), ii) inorganic Zn diet supplemented with 120 mg/kg of Zn from Zn sulfate ($ZnSO_4$), and iii) organic Zn diet supplemented with 120 mg/kg of Zn from PC-Zn. The body weight of pigs were recorded at the beginning, at the middle and at the end of the experiment, and the amount of feed supplied each day was recorded. Five barrows from each dietary treatment group were selected to be anesthetized and euthanized at the end of the trial to determine the Zn, Cu, Fe, and Mn concentrations, the hepatic metallothionein content, the levels of methane dicarboxylic aldehyde (MDA), Mn, and Cu/Zn superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) in the spleen, the levels of interleukin (IL)-2, IL-4, IL-10, interferon $(IFN)-{\gamma}$, $CD3^+$, $CD4^+$, and $CD8^+$ T lymphocyte. Results: The accumulation of Zn in the spleen, levels of SOD, GSH-Px, IL-4, IL-10, the proportions of $CD3^+$ and $CD4^+$ T lymphocyte, and the ratio of $CD4^+/CD8^+$ T lymphocyte were increased by organic Zn supplementation compared to ZnD, while the levels of MDA, $IFN-{\gamma}$, and proportion of $CD8^+$ T lymphocyte were lowered. Conclusion: These findings indicate that Zn can improve the antioxidant potential and immune functions of weaned piglets.

Keywords

Proteinate Complex Zinc;Growth Performance;Trace Elements Concentrations;Atioxidative Function;Immune Functions;Weaned Piglets

Acknowledgement

Supported by : National Natural Science Fund of China

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