Phase behavior of arbutin/ethanol/supercritical CO2 at elevated pressures

  • Han, Chang-Nam (Department of Advanced Chemical Engineering, Chonnam National University) ;
  • Kang, Choon-Hyoung (Department of Chemical Engineering, Chonnam National University)
  • Received : 2017.01.10
  • Accepted : 2017.03.20
  • Published : 2017.06.01


The phase behavior of a ternary system containing arbutin, which is effective for skin lightening, in a solvent mixture of ethanol and supercritical carbon dioxide ($CO_2$) was investigated. A high-pressure phase equilibrium apparatus equipped with a variable-volume view cell was used to measure the phase equilibrium loci of the ethanol+$CO_2$ binary mixture from 298.2 K to 313.2 K and pressures between 2 MPa and 9 MPa. The solubility of arbutin in the mixed solvent comprising ethanol and $CO_2$, which equivalently represents the critical locus of T-x, was determined as a function of temperature, pressure, and solvent composition by measuring the cloud points under various conditions. Throughout, the arbutin loading was maintained at 1.5 wt% on a $CO_2-free$ basis in the solvent mixture and the pressure and temperature were varied up to 14 MPa and 334 K, respectively. For a $CO_2$ loading less than 34 wt% on ethanol basis, the cloud point was not observed. However, the solid remained undissolved when the $CO_2$ loading exceeded 54 wt%. Between these loadings, steep and almost pressure-insensitive solubility curves, which extended downward to the vaporization boundary, were found.


Supported by : Industrial Facilities & Infrastructure Research Program (IFIP)


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