Dietary risk assessment for suspected endocrine disrupting pesticides in agricultural products in Busan, Korea

부산지역 유통 농산물의 내분비계 장애추정농약 위해평가

  • Kwon, Hyeon-Jeong (Busan Metropolitan City Institute of Health & Environment) ;
  • Ok, Yeon-Ju (Busan Metropolitan City Institute of Health & Environment) ;
  • Kim, Chan-Hee (Busan Metropolitan City Institute of Health & Environment) ;
  • Park, Mi-Jung (Busan Metropolitan City Institute of Health & Environment) ;
  • Hwang, Hye-Sun (Busan Metropolitan City Institute of Health & Environment) ;
  • Youn, Jong-Bae (Busan Metropolitan City Institute of Health & Environment) ;
  • Cha, Kyung-Suk (Busan Metropolitan City Institute of Health & Environment) ;
  • Jo, Hyun-Cheol (Busan Metropolitan City Institute of Health & Environment)
  • 권현정 (부산광역시 보건환경연구원) ;
  • 옥연주 (부산광역시 보건환경연구원) ;
  • 김찬희 (부산광역시 보건환경연구원) ;
  • 박미정 (부산광역시 보건환경연구원) ;
  • 황혜선 (부산광역시 보건환경연구원) ;
  • 윤종배 (부산광역시 보건환경연구원) ;
  • 차경숙 (부산광역시 보건환경연구원) ;
  • 조현철 (부산광역시 보건환경연구원)
  • Received : 2017.09.25
  • Accepted : 2017.12.18
  • Published : 2018.02.28


Studies on suspected endocrine disrupting pesticide (EDP) residues in agricultural products were carried out in 2016 in Busan, Korea. Twelve different EDPs, ranging in concentration between 0.003-2.049 mg/kg, were detected in 19.5% of 462 samples. About 0.2% of agricultural product samples exceeded the maximum residue limits (MRLs). Risk indices of all of the EDPs were less than 10% of the acceptable daily intake (ADI). The outcomes indicated that the risk groups at highest risk of exposure to diazinon (found in Korean cabbages) and carbendazim (found in apples) were females aged 40 to 49 and young males less than 10 years old, respectively. Based on the stochastic assessment at $95^{th}$ percentile (P95), risk index in these risk groups accounted for 8.38 and 2.98% of ADIs. The results showed that the occurrence of EDP residues in agricultural products could not be considered a public health problem.


  1. Lintelmann J, Katayama A, Kurihara N, Shore L, Wenzel A. Endocrine disruptors in the environment (IUPAC Technical Report). Pure Appl. Chem. 75: 631-681 (2003)
  2. Kim SH, Park MJ. Endocrine disrupting chemicals and pubertal development. Endocrinol. Metab. 27: 20-27 (2012)
  3. Lee CJ, Lee HJ, Yoon YD. Endocrine disrupters and reproduction. Endocrinol. Metab. 16: 596-623 (2001)
  4. Lee JB, Shin JS, Lee HD, Jeong MH, You AS, Kang KY. Risk assessment for estrogenic effect of the suspected endocrine disrupting pesticides. Korean J. Pestic. Sci. 8: 95-102 (2004)
  5. Matisova E, Hrouzkova S. Analysis of endocrine disrupting pesticides by capillary GC with mass spectrometric detection. Int. J. Env. Res. Pub. He. 9: 3166-3196 (2012)
  6. Heberer T, Dunnbier U. DDT metabolite bis (chlorophenyl) acetic acid: the neglected environmental contaminant. Environ. Sci. Technol. 33: 2346-2351 (1999)
  7. Noh HH, Lee KH, Lee JY, Park HK, Lee EY, Hong SM, Park YS, Kyung KS. Monitoring of endocrine disruptor-suspected pesticide residues in greenhouse soils and evaluation of their leachability to groundwater. Korean J. Pestic. Sci. 15: 441-452 (2011)
  8. Lammerding AM, Fazil A. Hazard identification and exposure assessment for microbial food safety risk assessment. Int. J. Food Microbiol. 58: 147-157 (2000)
  9. Bhanti M, Taneja A. Contamination of vegetables of different seasons with organophosphorous pesticides and related health risk assessment in northern India. Chemosphere 69: 63-68 (2007)
  10. He D, Ye X, Xiao Y, Zhao N, Long J, Zhang P, Fan Y, Ding S, Jin X, Tian C, Xu S, Ying C. Dietary exposure to endocrine disrupting chemicals in metropolitan population from China: A risk assessment based on probabilistic approach. Chemosphere 139: 2- 8 (2015).
  11. Jang MR, Moon HK, Kim TR, Yuk DH, Kim JH, Park SG. Dietary risk assessment for pesticide residues of vegetables in Seoul, Korea. Korean J. Nutr. 43: 404-412 (2010)
  12. Boobis AR, Ossendorp BC, Banasiak U, Hamey PY, Sebestyen I, Moretto A. Cumulative risk assessment of pesticide residues in food. Toxicol. Lett. 180: 137-150 (2008)
  13. Kaushik G, Satya S, Naik SN. Food processing a tool to pesticide residue dissipation-A review. Food Res. Int. 42: 26-40 (2009)
  14. Paik MK, Park BJ, Son KA, Kim JB, Hong SM, Kim WI, Im GJ, Hong MK. Probabilistic approach on dietary exposure assessment of neonicotinoid pesticide residues in fruit vegetables. Korean J. Pestic. Sci. 14: 110-115 (2010)
  15. Do YS, Kim JB, Kang SH, Kim NY, Eom MN, Yoon MH. Probabilistic exposure assessment of pesticide residues in agricultural products in Gyeonggi-do. Korean J. Pestic. Sci. 17: 117-125 (2013)
  16. Ryu JC. Overall review on endocrine disruptors. Korean J. Pestic. Sci. 6: 135-156 (2002)
  17. Park JS. Study of integrated pollution control for risk assessment and management system on endocrine disruptors. Available from: Accessed 2002.
  18. Kim CJ, Seung JJ, Lee SJ, Park YS, Ko SH. Calculation of food commodity intake for safety control of pesticide residues. Food Sci. Indus. 43: 67-78 (2010)
  19. U.S. Environmental Protection Agency (US/EPA). Final list of initial pesticide active ingredients and pesticide inert ingredients to be screened under the federal food, drug, and cosmetic act. Federal Register. 74: 17579-17585 (2009)
  20. Hrouzkova S, Matisova E. Endocrine disrupting pesticides. Available from: Accessed Jul. 25, 2012.
  21. U.S. Environmental Protection Agency (US/EPA). Final second list of chemicals for tier 1 screening. Available from: Accessed Jun. 26, 2014.
  22. Okkerman PC, Van der Putte I. Endocrine disrupters: Study on gathering information on 435 substances with insufficient data. European commission (EC) DG ENVIRONMENT: B4-3040/ 2001/325850/MAR/C2. pp. 1-52 (2002)
  23. World Health Organization (WHO). Endocrine disorders and children: children's health and the environment. Available from: Accessed Oct. 2011.
  24. National Institute of Food and Drug Safety Evaluation. Practical instructions for residual pesticide analysis method. 5th ed. Ministry of Food and Drug Safety, Korea. pp. 3-5 (2017)
  25. Lozowicka B, Kaczynski P, Paritova AE, Kuzembekova GB, Abzhalieva AB, Sarsembayeva NB, Alihan K. Pesticide residues in grain from Kazakhstan and potential health risks associated with exposure to detected pesticides. Food Chem. Toxicol. 64: 238-248 (2014)
  26. Korea Centers for Disease Control and Prevention. The sixth korea national health and nutrition examination survey (2013-2014). Available from: Accessed from 2013 to 2014.
  27. Kwon HJ. Monitoring and risk assessment of suspected endocrine disrupting pesticides in leafy vegetables. MS thesis, Pusan National University, Busan, Korea. (2015)
  28. Beane Freeman LE, Bonner MR, Blair A, Hoppin JA, Sandler DP, Lubin JH, Dosemeci M, Lynch CF, Knott C, Alavanja MCR. Cancer incidence among male pesticide applicators in the agricultural health study cohort exposed to diazinon. Am. J. Epidemiol. 162: 1070-1079 (2005)
  29. European Food Safety Authority (EFSA). Conclusion regarding the peer review of the pesticide risk assessment of the active substance: diazinon. EFSA Scientific report. 85: 1-73 (2006)
  30. Zubaidy MAI, Mousa Y, Hasan M, Mohammad F. Acute toxicity of veterinary and agricultural formulations of organophosphates dichlorvos and diazinon in chicks. J. Ind. Hyg. Toxicol. 62: 317-323 (2011)