Effect of Physical Properties and Bacterial Adherence Inhibition of Pit and Fissure Sealant Containing Bioactive Glass Nano Particles(BGn)

생체활성 유리 나노입자 첨가량에 따른 치면열구전색제의 물성평가와 세균부착 억제 효과

  • 전수경 (경동대학교 치위생학과) ;
  • 김동애 (경운대학교 치위생학과)
  • Received : 2018.01.09
  • Accepted : 2018.02.02
  • Published : 2018.03.28


In this study BGn-incorporated non-fluoride release of pit and fissure sealant $Concise^{TM}$ was developed to improve the mechanical properties and promote antibacterial effect of fit and fissure sealant with the original material. The mechanical properties and antibacterial activity of BGn incorporating vary-ing amounts bioactive glass nano particles(BGn) (0,0.5,1.0 and 2.0 wt% in sealant) were characterized composition of the resulting were investigated. The solubility to aid absorption was calculated by weighing specimens with a diameter of 10 mm and a thickness of 2 mm according to ISO 4049 (2009). The antimicrobial effect was evaluated using three strains of S. mutans, S. aureus and E. coli. The absorbance of the test results was as high as the addition of BGn increased, and the lower the solubility as the solubility was added(p<0.05). Adhesion experiment results S. mutans in contrast to the control group $Concise^{TM}$, BGn-added experimental group showed a somewhat lower adherent surface but no statistically significant difference was observed (p<0.05). However S. aureus and E. coli statistical analysis indicated a significant difference for antibacterial agents between control and BGn containing(p<0.05). It seems that this BGn proved that even a antibacterial effect was demonstrated. Therefore, it was suggest that the additional effects of BGn and research on a wide range of substances.


Supported by : 경운대학교


  1. W. P. Rock, "The effectiveness of fissure sealant resins," J Dent Educ, Vol.48, pp.27-31, 1984.
  2. A. Ahovuo-Saloranta, A. Hiiri, A. Nordblad, H. Worthington, and M. Makela, "Pit and fissure sealants for preventing dental decay in the permanent teeth of children and adolescents," Cochrane Database Syst Rev, Vol.3, CD001830, 2008.
  3. 이효설, 나노하이드록시아파타이트를 첨가한 치면열구전색제의 탈회 가능성, 연세대학교 치의학 대학원, 석사학위논문, 2008.
  4. S. W. Park, Y. K. Lee, Y. U. Kim, M. C. Kim, K. N. Kim, and B. J. Choi, "The effect of hydroxyapatite on the remineralization of dental fissure sealant," Key Engin Mat, Vol.284, pp.35-38, 2005.
  5. J. S. An, J. W. Park, H. W. Seo, and S. Y. Lee, "Antibacterial Properties of Pit and Fissure Sealant Containing S-PRG filler on Streptococcus mutans," J Korean Acad Pediatr Dent, Vol.42, No.4, pp.302-311, 2015.
  6. 김학범, 항균필러를 함유한 광중합형 치면열구전색제의 특성, 연세대학교 대학원 치의학대학원, 박사학위논문, 2016.
  7. S. Y. Yang, Y. Z. Piao, S. M. Kim, Y. K. Lee, K. N. Kim, and K. M. Kim, "Acid neutralizing, mechanical and physical properties of pit and fissure sealants containing melt-derived 45s5 bioactive glass," Dent Mater, Vol.29, No.12, pp.1228-1235, 2013.
  8. 김재민, 임상욱, 조화영, 마재경, 김정숙, 김교한, 송근배, 최연희, "치면열구전색제와 충전재료에 대한 우식유발 세균의 부착특성 비교," 대한치과재료학회지, Vol.42, No.3, pp.229-237, 2015.
  9. S. Kimyai, F. Lotfipour, R. Pourabbas, A. Sadr, S. Nikazar, and M. Milani, "Effect of two prophylaxis methods on adherence of Streptococcus mutans to microfilled composite resin and giomer surfaces," Med Oral Patol Oral Cir Bucal, pp.e561-567, 2011.
  10. A. Ogawa, S. Furukawa, S. Fujita, J. Mitobe, T. Kawarai, N. Narisawa, and T. Sekizuka, "Inhibition of Streptococcus mutans biofilm formation by Streptococcus salivarius FruA," Appl Environ Microbiol, Vol.77, No.5, pp.1572-1580, 2011.
  11. 김희정, 김경남, 최병재, 이종갑, "$SrF_2$계 충진재 를 함유한 광중합형 복합레진의 특성," J Korean Acad Pediatr Dent, Vol.28, No.1, pp.54-66, 2001.
  12. 문장원, 유미경, 이광원, "불소 방출성 수복재의 불소 재충전에 따른 불소유리와 표면 변화," 대한치과턱관절기능교합학회지, 제21권, 제1호, pp.26-32, 2005.
  13. J. Arends, G. E. Dijkman, and A. G, Dijkman, "Review of fluoride release and secondary caies reductio nby fluorideationg composites," Adv Dent Res, Vol.9, No.4, pp.367-376, 1995.
  14. 공은경, CPP-ACP 적용이 치면열구전색제의 결합강도에 미치는 영향, 이화여자대학교 임상치의학대학원, 석사학위논문, 2010.
  15. S. Hu, J. Chang, M. Liu, and C. Ning, "Study on antibacterial effect of 45S5 Bioglass(R)," J Mater Sci, Vol.20, No.1, pp.281-286, 2009.
  16. H. Yli-Urpo, T. Narhi, and E. Soderling, "Antimicrobial effects of glass ionomer cements containing bioactive glass (S53P4) on oral micro-organisms in vitro," Acta Odontologica Scandinavica, Vol.61, No.4, pp.241-246, 2003.
  17. M. Tanagawa, K. Yoshida, S. Matsumoto, T. Yamada, and M. Atsuta, "Inhibitory effect of antibacterial resin composite against Streptococcus mutans", Caries Res, Vol.33, No.5, pp.366-371, 1999.
  18. Y. Kudou, K. Obara, T. Kawashima, M. Kubota, S. Abe, T. Endo, M. Komatsu, and R. Okuda, "Addition of Antibacterial Agents to MMA-TBB Dentin Bonding Systems," Dent Mater J Mar, Vol.19, No.1, pp.65-74, 2000.
  19. A. Y. Harhash, I. I. ElSayad, and A. G. Zaghloul, "A comparative in vitro study on fluoride release and water sorption of different flowable esthetic restorative materials," Eur J Dent, Vol.11, No.2, p.174, 2017.
  20. N. C. Beriat and D. Nalbant "Water absorption and HEMA release of resin-modified glass-ionomers," Eur J Dent., Vol.3, No.4, p.267, 2009.
  21. T. Jaakkola, J. Rich, T. Tirri, T. Närhi, M. Jokinen, J. Seppala, and A. Yli-Urpo, "In vitro Ca-P precipitation on biodegradable thermoplastic composite of poly ($\varepsilon$-caprolactone-co-DL-lactide) and bioactive glass (S53P4)," Biomater, Vol.25, No.4, pp.575-581, 2004.
  22. J. Y. Choi, H. H. Lee, and H. W. Kim, "Bioactive sol-gel glass added ionomer cement for the regeneration of tooth structure," J Mater Sci Mater Med, Vol.19, No.10, pp.3287-3294, 2008.
  23. 이선영, 김재곤, 백병주, 양연미, 이경열, 이용훈, 김미아, "구강 내 세균에 대한 Essential oil의 항균효과에 관한 연구," J Korean Acad Pediatr Dent, 제36권, 제1호, pp.1-11, 2009
  24. 정미애, 김동애, "기능화 다중벽 탄소나노튜브를 첨가한 글라스아이오노머 시멘트의 항균효과 및 기계적 성질," 한국콘텐츠학회논문지, 제17권, 제10호, pp.300-306, 2017.