A Systemic Review of Studies for Traditional Chinese Treatment of Intestinal Metaplasia - Research using CNKI

장상피화생(腸上皮化生) 치료에 대한 최신 임상 연구 동향 - CNKI 검색을 중심으로

  • Lee, Bo-ram (Dept. of Korean Internal Medicine, College of Korean Medicine, Dong-Eui University) ;
  • Kim, Won-ill (Dept. of Korean Internal Medicine, College of Korean Medicine, Dong-Eui University)
  • 이보람 (동의대학교 한의과대학 내과학교실) ;
  • 김원일 (동의대학교 한의과대학 내과학교실)
  • Received : 2018.09.28
  • Accepted : 2018.12.26
  • Published : 2018.12.30


Objectives: The purpose of this research is to investigate recent clinical studies of Intestinal Metaplasia (IM) based on a search of the China National Knowledge Infrastructure (CNKI). Methods: We investigated recent clinical studies of Oriental medicine therapies in traditional Chinese medical journals for IM through a CNKI search. 20 clinical articles published from 2010 to 2016 were analyzed. This study examined the authors, publication years, types of studies, criteria for diagnosis and evaluation, periods, purposes of study and articles classified by methods of treatment. Results: Most of articles were classified as randomized controlled trial. IM was diagnosed using gastroscopy, pathological examination and clinical symptoms in a high proportion of articles. The criteria for evaluation most frequently used were the effective ratios of clinical symptoms, gastroscopy and pathological tests. The methods of treatment in all studies were Chinese herb medicine. Acupuncture, acupoint injection therapy, and embedding therapy were also used in several studies. Conclusion: In this study, the Chinese treatment for IM was markedly effective. To improve the treatment of IM in Korea, many clinical studies and case reports are required, based on Chinese medicine.


  1. National Cancer Center. Cancer Facts &Figures 2015 in the Republic of Korea. Ministry of Health & Welfare Republic of Korea. 2015:19-42.
  2. Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J. Harrison's Principle of Internal medicine. 16th edition. Seoul: Publishing company MIP; 2006, p. 569-71.
  3. Taki K, Kuwabara N. Studies on histogenesis of the gastric carcinoma using minute cancers. Pathol Res Pract 1981;172(1-2):176-90.
  4. Seo SI, Sim MS, Moon SE. Significance of Intestinal Metaplasia in Stomach Cancer. J Korean Surg Soc1988;11(8-8):1.
  5. Study Group of Millennium Genome Project for Cancer. Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer. Nat Genet 2008;40(6):730-40.
  6. Huh KC, Son SH, Hur JW. Subtypes of Intestinal Metaplasia in Chronic Gatritis. Clin Endosc 2000;21(2):593-601.
  7. Bonne C, Hartz PH, Klerks JV, Postuma JH, Radsam W, Tjokronegoro S. Morphology of the stomach and gastric secretion in Malays and the different incidence of gastric ulcer and cancer in these races. Am J Cancer 1938;33(2):165-72.
  8. Correa P. A human model of gastric carcinogenesis. Cancer Res 1988;48(13):3554-60.
  9. 王丽媛. 罗英化浊解毒方治疗慢性萎缩性胃炎伴肠上皮化生临床研究. 河北医科大学: 河北医科大学, 2016.
  10. 孙林波, 刘俊杰, 陈丽萍. 香砂温中汤治疗慢性萎缩性胃炎伴肠上皮化生32例. 现代中医药 2016;36(1) :45-6.
  11. Zheng FM, Zheng LL, Zheng ZJ. Clinical Observation on Xiaopi Yuwei Decoction with Weifuchun Tablets in the Treatment of 64 cases of Chronic Atrophic Gastritis with Intestinal Metaplasia or Dyspepsia. J Traditional Chinese Med 2015;(4):311-4.
  12. 刘宪莉, 于春鹏, 谢迪, 刘巍, 刘浩. 柴芍消痞汤治疗慢性萎缩性胃炎伴肠上皮化生效果研究. 科技创新导报 2015;16(16):25.
  13. 郑逢民, 戴孟, 叶方益, 郑乐乐. 消痞愈萎汤治疗萎缩性胃炎伴肠上皮化生40例观察. 浙江中医杂志 2014;49(4):244-5.
  14. 林启有, 陈瑞发, 欧阳东亮. 柴芍消痞汤治疗慢性萎缩性胃炎伴肠上皮化生的临床研究. 中西医结合研究 2014;6(4):204-5.
  15. Zhang AM, Ham J, Zhang RC. The Effect of Yiqi Huasheng decoction on the Treatment of Intestinal Metaplasia of Gastric Mucosa. Chinese J Integrated Traditional and Western Med on Dig 2014;22(11):640-3.
  16. Zhang MF. A Clinical Research of Shenqi Decoction to Treat Chronic Atrophic Gastritis with Intestianl Metaplasia. Nanjing University of Chinese Medicine2015.
  17. 刘悦明. 半夏泻心汤加味治疗肠上皮化生65例. 黑龙江中医药 2013;42(6):31.
  18. Hong WH, Kou SJ, Su HY. Effect of Decoction for Nourishing Stomach Combined with Acupoint Injection on Chronic Atrophic Gastiritis Accompanied with Intestinal Metaplasia : Report of 56 Cases. Shanxi J Traditional Chinese Med 2013;29(1) :14-5, 19.
  19. Feng DQ, Zhu MP, Shi HT. Clinical Effects of 'Changhua Recipe' in Treating Chronic Atrophic Gastritis with Intestinal Metaplasia. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai2013;27(2):32-5.
  20. Zhang NN. The Clinical Study on the Efficacy of Weikang Decoction on Chronic Atrophic Gastritis with the Intestinal Metaplasia. HeBei Medical University2013.
  21. 高征, 刘银伟, 张翠月. 补泻萎愈汤配合针刺治疗慢性萎缩性胃炎伴肠上皮化生42例. 中医杂志 2012;53(15):1323-4.
  22. Liu XF. Clinical Observation on Therapeutic Effect of Huazhuojiedufang on Chronic Atrophic Gastritis with Intestinal Metaplasia. HeBei University2015.
  23. 宋占营. 中药汤剂治疗慢性萎缩性胃炎伴肠上皮化生的临床观察. 新疆中医药 2011;29(3):6-8.
  24. 潘文斌, 梁霞, 王丽荣, 陆廷信. 四合汤合穴位埋线治疗慢性萎缩性胃炎伴肠上皮化生60例. 中国中医药现代远程教育 2011;9(16):36-7.
  25. 幸军, 冯青青, 李春安, 樊拖迎. 中西医结合治疗萎缩性胃炎肠上皮化生临床观察. 临床荟萃 2011;26(17):1546-7.
  26. 王宁, 张国. 活胃治萎汤治疗慢性萎缩性胃炎伴肠上皮化生疗效观察. 陕西中医 2011;32(8):1010-1.
  27. Cao ZQ, Xiang HJ, Zhao H. Clinical Research of Qilian Shupi Granule in the Treatment of Chronic Atrophic Gastritis with Intestinal Metaplasia. World J Integrated Traditional and Western Med 2010;5(10):871-2.
  28. 邱岳. 化瘀解毒益气法治疗慢性萎缩性胃炎伴肠上皮化生的临床研究. 北京中医药大学 2010.
  29. 中华医学会消化病学分会. 中国慢性胃炎共识意见. 中华消化内镜杂志 2007;24(1):58-63.
  30. 中华医学会消化内镜学分会. 慢性胃炎的内镜分型分级标准及治疗的试行意见. 中华消化内镜杂志 2004;21(2):77-8.
  31. 张万岱, 陈治水, 危北海. 慢性胃炎的中西医结合诊治方案. 世界华人消化杂志 2004;12(11):2697-700.
  32. 郑芝田. 胃肠病学. 北京: 人民卫生出版社; 2000, p. 225-35.
  33. 李乾构, 周学文, 单兆伟. 中医消化病诊疗指南. 北京: 中国中医药出版社; 2006, p. 315.
  34. 中华人民共和国卫生部医政司. 中国常见恶性肿瘤诊治规范. 北京: 北京医科大学 中国协和医科大学联合出版社; 1991, p. 36.
  35. 郑筱萸, 中药新药临床研究指导原则, 北京: 中国医药科技出版社; 2005, p. 214-9.
  36. 中华中医药学会脾胃病分会. 慢性萎缩性胃炎中医诊疗共识意见. 中国中西医结合消化杂志 2010;18(5):345-9.
  37. Milne AN, Carneiro F, O'Morain C, Offerhaus GJ. Nature meets nurture: molecular genetics of gastric cancer. Human genetics 2009;126(5):615-28.
  38. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process. Cancer Res 1992;52(24):6735-40.
  39. Park JH. Managemetn of precancerous lesion in the stomach. The Korean Society of Clinical Oncology2012;25(3):69-74.
  40. Filipe MI, Munoz N, Matko I, Kato I, Pompe-Kirn V, Jutersek A, et al. Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int J Cancer 1994;57(3):324-9.
  41. Kim TH, Lee CH, Chang DK, Kim JS, Jung HC, Song IS, et al. Helicobacter pylori Infection and Risk of Gastric Cancer : Correlation with Subtypes of Intestinal Metaplaisa. Korean J Gastoenterol1999;33(2):170-82.
  42. Matsukura N, Suzuki K, Kawachi T, Aoyagi M, Sugimura T, Kitaoka H, et al. Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation of complete and incomplete types of intestinal metaplasia to minute gastric carcinomas. J Natl Cancer Inst1980;65(2):231-40.
  43. Huang CB, Xu J, Huang JF, Meng XY. Sulphomucin colonic type intestinal metaplasia and carcinoma in the stomach. Cancer 1986;57(7):1370-5.<1370::AID-CNCR2820570721>3.0.CO;2-J
  44. Yoon CM, Park KS, Bom HS, Park IC. Subtypes of Intestianl Metaplasia in Endoscopic Biopsies of Various Gastric Disease. Korean J Gastroenterol 1987;19(1):13-7.
  45. Rokkas T, Filipe MI, Sladen GE. Detection of an increased incidence of early gastric cancer in patients with intestinal metaplasia type III who are closely followed up. Gut 1991;32(10):1110-3.
  46. Kuipers EJ, Uyterlinde AM, Pena AS, Roosendaal R, Pals G, Nelis GF, et al. Long-term sequelae of Helicobacter pylori gastritis. Lancet 1995; 345(8964):1525-8.
  47. Nardone G, Staibano S, Rocco A, Mezza E, D'armiento FP, Insabato L, et al. Effect of Helicobacter pylori infection and its eradication on cell proliferation, DNA status, and oncogene expression in patients with chronic gastritis. Gut 1999;44(6):789-99.
  48. Lee Y, Jeon YC, Koo TY, Cho HS, Byun TJ, Kim TY, et al. Histological Changes of Gastric Atrophy and Intestinal Metaplasia after Helicobacter pylori Eradication. Korean J Gastroenterol 2007; 50(5):299-305.
  49. 李振华, 李郑生. 中国传统脾胃病学. 郑州: 郑州中原农民出版社; 1995, p. 109-10.
  50. Lee KM. Two Cases of Chronic Gastritis Treated with Wihwa Herbal-acupuncture. The J of Acu 2003;20(6):218-25.
  51. Yoon HJ, Bae HI, Lee JH, Kim SC, Jun CH, Yang CH, et al. A Case of Pernicious Anemia Associated wiht Chronic Atrophic Gastritis. The DongGuk Journal of Medicine 1994;2(1) :335-43.
  52. Koike K, Zhang ZX, Sakamoto Y, Jikihara H, Masuhara K, Murakami K, et al. The herbal medicine unkei-to stimulates cytokine-induced neutrophil chemoattractant production in the pituitary folliculo-stellate like cell line. Am J Reprod Immunol1998;39(4):249-55.
  53. Lee SI, An DK, Shin MK. Clinical Application of Traditional Herb Medicine. Seoul: SungBoSa; 1982, p. 515-20.
  54. Traditional Korean Medicine Pharmacology Textbook Compilation Committee. Traditional Korean Herb Pharmacology. Seoul: ShinilBooks; 2005, p. 279-81.
  55. 张永祥. 中药药理学新论. 北京: 人民卫生出版社; 2004, p. 223.
  56. The Acupuncture Compilation Committee. The Acupuncture and Moxibustion(Sang). Seoul: JipMoonDang; 2008, p. 63-4, 135-6, 305-6.