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Microfluidic Device for Ultrasound Image Analysis based on 3D Printing

초음파 영상 분석을 위한 3D 프린팅 기반 미세유체소자

  • Kang, Dongkuk (School of Mechanical Engineering, Pusan National University) ;
  • Hong, Hyeonji (School of Mechanical Engineering, Pusan National University) ;
  • Yeom, Eunseop (School of Mechanical Engineering, Pusan National University)
  • Received : 2018.03.19
  • Accepted : 2018.04.09
  • Published : 2018.04.30

Abstract

For the measurement of biophysical properties related with cardiovascular diseases (CVD), various microfluidic devices were proposed. However, many devices were monitored by optical equipment. Ultrasound measurement to quantify the biophysical properties can provide new insights to understand the cardiovascular diseases. This study aims to check feasibility of microfluidic device for ultrasound image analysis based on 3D printer. To facilitate acoustic transmission, agarose solution is poured around 3D mold connected with holes of the acrylic box. By applying speckle image velocimetry(SIV) technique, flow information in the bifurcated channel was estimated. Considering that ultrasound signal amplitude is determined by red blood cell (RBC) aggregation, RBC aggregation in the bifurcated channel can be estimated through the analysis of ultrasound signal. As examples of microfluidic device which mimic the CVD model, velocity fields in microfluidic devices with stenosis and aneurysm were introduced.

Acknowledgement

Supported by : 한국연구재단

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