- Volume 28 Issue 2
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DRF and Single Dose Oral Toxicity Study of ChondroT in Rat
Rat에서 ChondroT의 DRF 및 단회독성 시험
- Lim, Yong-Ha (Department of Rehabilitation Medicine of korean medicine, College of Korean Medicine, Dongshin University) ;
- Jeong, Ji-Won (Department of Rehabilitation Medicine of korean medicine, College of Korean Medicine, Dongshin University) ;
- Kim, Sun-Gil (Department of Rehabilitation Medicine of korean medicine, College of Korean Medicine, Dongshin University) ;
- Kim, Ji-Hoon (Department of Rehabilitation Medicine of korean medicine, College of Korean Medicine, Dongshin University) ;
- Kim, Seon-Jong (Department of Rehabilitation Medicine of korean medicine, College of Korean Medicine, Dongshin University)
- 임용하 (동신대학교 한의과대학 한방재활의학과 교실) ;
- 정지원 (동신대학교 한의과대학 한방재활의학과 교실) ;
- 김선길 (동신대학교 한의과대학 한방재활의학과 교실) ;
- 김지훈 (동신대학교 한의과대학 한방재활의학과 교실) ;
- 김선종 (동신대학교 한의과대학 한방재활의학과 교실)
- Received : 2018.03.19
- Accepted : 2018.04.03
- Published : 2018.04.30
Objectives The purpose of this experiment is to evaluate 4 weeks DRF (Dose Rate Finding) and single oral dose toxicity of ChondroT in rats. Methods In 4-week DRF, male and female Sprague-Dawely rats were treated with ChondroT at oral dose of 0, 500, 1000, and 2000 mg/kg. clinical signs, body weight, food consumption, necropsy findings, organ weight, hematological and blood-chemical parameters, and histological findings were monitored for 4 weeks. Also, after single oral administration of ChondroT, mortality, clinical signs, body weight, and necropsy findings were minitored for 2 weeks. Results In 4-week DRF and single dose oral toxicity study of ChondroT in sprague-Dawley rats, ChondroT did not exhibit any toxicity under the study conditions employed. Conclusions The results suggested a no-observed adverse effects level (NOAEL) was over 2,000 mg/kg/day in SD rats after oral administration, this study could be used as basic study of the repeated dose 13-week oral toxicity study of ChondroT.
Supported by : 한국보건산업진흥원
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