DOI QR코드

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Antiglycation and antioxidant activity of four Iranian medical plant extracts

  • Safari, Mohammad Reza ;
  • Azizi, Omid ;
  • Heidary, Somayeh Sadat ;
  • Kheiripour, Nejat ;
  • Ravan, Alireza Pouyandeh
  • Received : 2017.12.21
  • Accepted : 2018.05.17
  • Published : 2018.06.30

Abstract

Objective: Diabetes mellitus (DM) is the most common metabolic disorder that defined by chronic hyperglycemia for the deficiency in insulin secretion or resistance. Hyperglycemia could induce non-enzymatic glycation of proteins. It has been suggested that some traditional plants can improve blood glucose and inhibit glycation process. This work evaluates and compares the anti-glycation activities of four Iranian plant extracts in vitro. Methods: The methanolic extract of "Fumaria officinalis, Stachys lavandulifolia, Salvia hydrangea and Rosa Damascene" was prepared in three different concentrations. Phenolic, flavonoids content and antioxidant activity were evaluated. The multistage glycation markers- fructosamines (early stage), protein carbonyls (intermediate stage) and ${\beta}$ aggregation of albumin were investigated in the bovine serum albumin (BSA)/ glucose systemt. Results: All plants showed the high potency of scavenging free radicals and glycation inhibition in the following order: Fumaria officinalis> Rosa Damascene> Stachys lavandulifolia > Salvia hydrangea. There was a significant correlation between antioxidant and anti-glycation activity. Also, the antioxidant and anti-glycation capacity of extracts correlated with total phenolic and flavonoids content. Conclusion: Our findings demonstrated that the studied plants are good sources of anti-glycation and antioxidant compounds and, these properties can primarily attributable to phenolics, particularly flavonoids.

Keywords

Diabetes mellitus;Glycosylation;Antioxidants

References

  1. Janghorbani M, Van Dam RM, Willett WC, Hu FB. Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol. 2007;166:495-505. https://doi.org/10.1093/aje/kwm106
  2. Ghadermazi R, Khoshjou F, Hossini Zijoud SM, Behrooj H, Kheiripour N, Ganji M, et al. Hepatoprotective effect of tempol on oxidative toxic stress in STZ-induced diabetic rats. Toxin Rev. 2017; 37(1): 1-5.
  3. Cade WT. Diabetes-related microvascular and macro-vascular diseases in the physical therapy setting. Phys Ter. 2008;88(11):1322-35.
  4. Lee P, Wu X. Modifications of human serum albumin and their binding effect. Curr Pharm Des. 2015;21(14):1862-5. https://doi.org/10.2174/1381612821666150302115025
  5. Anguizola J, Matsuda R, Barnaby OS, Hoy K, Wa C, De-Bolt E, et al. Glycation of human serum albumin. Clin Chim Acta. 2013;425:64-76. https://doi.org/10.1016/j.cca.2013.07.013
  6. Singh VP, Bali A, Singh N, Jaggi AS. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol. 2014;18(1):1-14. https://doi.org/10.4196/kjpp.2014.18.1.1
  7. GarciassMartinez R, Caraceni P, Bernardi M, Gines P, Arroyo V, Jalan R. Albumin: pathophysiologic basis of its role in the treatment of cirrhosis and its complications. Hepatology. 2013;58(5):1836-46. https://doi.org/10.1002/hep.26338
  8. Peng X, Zheng Z, Cheng K-W, Shan F, Ren G-X, Chen F, et al. Inhibitory effect of mung bean extract and its constituents vitexin and isovitexin on the formation of advanced glycation endproducts. Food Chem. 2008; 106(2): 475-81 https://doi.org/10.1016/j.foodchem.2007.06.016
  9. Javidnia K, Mojab F, Mojahedi S. Chemical constituents of the essential oil of Stachys lavandulifolia Vahl from Iran. Iran J Pharm Res. 2004;3:61-3.
  10. Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav. 2003;75(3):651-9. https://doi.org/10.1016/S0091-3057(03)00108-4
  11. Nickavar B, Abolhasani L. Bioactivity-guided separation of an ${\beta}$-amylase inhibitor flavonoid from Salvia virgata. Iran J Pharm Res. 2013;12(1):57-61.
  12. Gholamhoseinian A, Fallah H, Sharif far F. Inhibitory effect of methanol extract of Rosa damascena Mill. flowers on ${\alpha}$-glucosidase activity and postprandial hyperglycemia in normal and diabetic rats. Phytomedicine. 2009;16(10):935-41. https://doi.org/10.1016/j.phymed.2009.02.020
  13. Fathiazad F, Hamedeyazdan S, Khosropanah MK, Khaki A. Hypoglycemic activity of Fumaria parvifora in streptozotocin-induced diabetic rats. Adv Pharm Bull. 2013;3(1):207-10.
  14. Nasri H, Shirzad H, Baradaran A, Rafeian-kopaei M. Antioxidant plants and diabetes mellitus. J Res Med Sci. 2015;20(5):491. https://doi.org/10.4103/1735-1995.163977
  15. Ravan AP, Shafei G, Eftekharian MM, Azizi A, Roshanaei G, Goudarzi F, et al. Inhibition of albumin glycation at different stages by four anti-diabetic plant extracts correlates with polyphenols and antioxidant capacity in vitro. Br J Pharm Res. 2016;12(2):1-8.
  16. Tupe RS, Sankhe NM, Shaikh SA, Kemse NG, Khaire AA, Phatak DV, et al. Nutraceutical properties of dietary plants extracts: Prevention of diabetic nephropathy through inhibition of glycation and toxicity to erythro-cytes and HEK293 cells. Pharm Biol. 2015;53(1):40-50. https://doi.org/10.3109/13880209.2014.910236
  17. Sefi M, Fetoui H, Makni M, Zeghal N. Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats. Food Chem Toxicol. 2010;48(7):1986-93. https://doi.org/10.1016/j.fct.2010.05.005
  18. McPherson JD, Shilton BH, Walton DJ. Role of fructose in glycation and cross-linking of proteins. Biochemistry. 1988;27(6):1901-7. https://doi.org/10.1021/bi00406a016
  19. Uchida K, Kanematsu M, Sakai K, Matsuda T, Hattori N, Mizuno Y, et al. Proc Natl Acad Sci U S A. Proceedings of the National Academy of Sciences. 1998;95:4882-7. https://doi.org/10.1073/pnas.95.9.4882
  20. Tupe RS, Sankhe NM, Shaikh SA, Phatak DV, Parikh JU, Khaire AA, et al. Aqueous extract of some indigenous medicinal plants inhibits glycation at multiple stages and protects erythrocytes from oxidative damage-an in vitro study. J Food Sci Technol. 2015;52(4):1911-23. https://doi.org/10.1007/s13197-013-1211-8
  21. Sadowska-Bartosz I, Bartosz G. Prevention of protein glycation by natural compounds. Molecules. 2015;20(2):3309-34. https://doi.org/10.3390/molecules20023309
  22. Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010;107(9):1058-70. https://doi.org/10.1161/CIRCRESAHA.110.223545
  23. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev. 2010;4(8):118. https://doi.org/10.4103/0973-7847.70902
  24. Ivanov I, Vrancheva R, Marchev A, Petkova N, Aneva I, Denev P, et al. Antioxidant activities and phenolic compounds in Bulgarian Fumaria species. Int J Curr Microbiol Appl Sci. 2014;3(2):296-306.
  25. Ginova A, Mihalev K, Kondakova V. Antioxidant Capacity of petals and leaves from different rose (Rosa damascena Mill) Plantations in Bulgaria. Int J Pure App Biosci. 2013;1(2):38-43.
  26. Rahimi Khoigani S, Rajaei A, Goli SA. Evaluation of antioxidant activity, total phenolics, total flavonoids and LC-MS/MS characterisation of phenolic constituents in Stachys lavandulifolia. Nat Prod Res. 2017;31(3):355-8. https://doi.org/10.1080/14786419.2016.1233410
  27. Zarei A, Vaezi G, Malekirad AA, Abdollahi M. Effects of ethanol extract of Salvia hydrangea on hepatic and renal functions of streptozotocin-induced diabetic rats. Avicenna J Phytomed. 2015;5(2):138-147.
  28. Omodanisi EI, Aboua YG, Oguntibeju OO. Assessment of the anti-hyperglycaemic, anti-inflammatory and antioxidant activities of the methanol extract of Moringa oleifera in diabetes-induced nephrotoxic male wistar rats. Molecules. 2017;22(4):439. https://doi.org/10.3390/molecules22040439
  29. Gkogkolou P, Bohm M. Advanced glycation end products: Key players in skin aging? Dermatoendocrinol. 2012;4(3):259-70. https://doi.org/10.4161/derm.22028
  30. Seneviratne C, Dombi GW, Liu W, Dain JA. In vitro glycation of human serum albumin by dihydroxyacetone and dihydroxyacetone phosphate. Biochem Biophys Res Commun. 2012;417(2):817-23. https://doi.org/10.1016/j.bbrc.2011.12.043
  31. Rondeau P, Bourdon E. The glycation of albumin: structural and functional impacts. Biochimie. 2011;93(4):645-58. https://doi.org/10.1016/j.biochi.2010.12.003
  32. Ho S-C, Wu S-P, Lin S-M, Tang Y-L. Comparison of anti-glycation capacities of several herbal infusions with that of green tea. Food Chem. 2010;122(3):768-74. https://doi.org/10.1016/j.foodchem.2010.03.051
  33. Yeh W-J, Hsia S-M, Lee W-H, Wu C-H. Polyphenols with antiglycation activity and mechanisms of action: A review of recent findings. J Food Drug Anal. 2017;25(1):84-92. https://doi.org/10.1016/j.jfda.2016.10.017
  34. Kaewnarin K, Niamsup H, Shank L, Rakariyatham N. An-tioxidant and antiglycation activities of some edible and medicinal plants. Chiang Mai J Sci. 2014;41(1):105-16.
  35. Chen Y-F, Roan H-Y, Lii C-K, Huang Y-C, Wang T-S. Relationship between antioxidant and antiglycation ability of saponins, polyphenols, and polysaccharides in Chinese herbal medicines used to treat diabetes. J Med Plant Res. 2011;5(11):2322-31.
  36. Grzegorczyk-Karolak I, Golab K, Gburek J, Wysokissska H, Matkowski A. Inhibition of Advanced Glycation End-Product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L. Molecules. 2016;21(6):739. https://doi.org/10.3390/molecules21060739
  37. Rahzani K, Malekirad AA, Zeraatpishe A, Hosseini N, Seify SMR, Abdollahi M. Anti-oxidative stress activity of Stachys lavandulifolia aqueous extract in human. Cell J. 2013;14(4):314.

Acknowledgement

Supported by : Hamadan University of Medical Sciences