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Three Adverse Events Reports of Simple Exanthematous Eruption after Sumsu (Bufonis Venenum) Pharmacopuncture Topical Treatment

섬수약침 국소시술 이후 발생한 단순 피부 발진: 3 이상사례 보고

  • Yoon, Sang-Hoon ;
  • Jo, Hee-Geun ;
  • Song, Min-Yeong ;
  • Seo, Hyung-Sik
  • 윤상훈 ;
  • 조희근 ;
  • 송민영 ;
  • 서형식
  • Received : 2018.06.11
  • Accepted : 2018.07.11
  • Published : 2018.07.31

Abstract

Three cases of simple exanthematous eruption were suspected during Sumsu (Bufonis Venenum) pharmacopuncture (SP) topical anesthesia for acupotomy. Patients had skin rash with pruritus on both ankle, posterior neck, and left shoulder after 11, 12, and 7 times of SP treatment, respectively. There were no cases of systemic manifestations or changes in vital signs. As a result of using the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) causality assessment, all the cases were evaluated as 'unlikely'. However, the results of using the Korean algorithm for assessing the causality of drug adverse reactions version 2.0 were evaluated as 'possible'. This report is the first case report on adverse events suspected of occurring after SP treatment. Although the causal relationship between suspected intervention and the adverse event is not clear, there was a difficulty in completely excluding the possibility. Additional safety studies will be required to make SP more widely available.

Keywords

Bufonis Venenum;Pharmacopuncture;Injection site reaction;Drug eruptions

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Acknowledgement

Supported by : 청연의학연구소