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Chemicals from Cimicifuga dahurica and Their Inhibitory Effects on Pro-inflammatory Cytokine Production by LPS-stimulated Bone Marrow-derived Dendritic Cells

  • Thao, Nguyen Phuong (Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST)) ;
  • Lee, Young Suk (College of Pharmacy, Chungnam National University) ;
  • Luyen, Bui Thi Thuy (Hanoi University of Pharmacy) ;
  • Van Oanh, Ha (Hanoi University of Pharmacy) ;
  • Ali, Irshad (School of Medicine and Jeju Research Center for Natural Medicine, Jeju National University) ;
  • Arooj, Madeeha (School of Medicine and Jeju Research Center for Natural Medicine, Jeju National University) ;
  • Koh, Young Sang (School of Medicine and Jeju Research Center for Natural Medicine, Jeju National University) ;
  • Yang, Seo Young (College of Pharmacy, Chungnam National University) ;
  • Kim, Young Ho (College of Pharmacy, Chungnam National University)
  • Received : 2018.03.21
  • Accepted : 2018.05.01
  • Published : 2018.09.30

Abstract

Inflammation is a biological response caused by overactivation of the immune system and is controlled by immune cells via a variety of cytokines. The overproduction of pro-inflammatory cytokines enhances abnormal host immunity, resulting in diseases such as rheumatoid arthritis, cardiovascular disease, Alzheimer's disease, and cancer. Inhibiting the production of pro-inflammatory cytokines such as interleukin (IL)-12p40, IL-6, and tumor necrosis factor $(TNF)-{\alpha}$ might be one way to treat these conditions. Here, we investigated the anti-inflammatory activity of compounds isolated from Cimicifuga dahurica (Turcz.) Maxim., which is traditionally used as an antipyretic and analgesic in Korea. In primary cell culture assays, 12 compounds were found to inhibit the production of pro-inflammatory cytokines (IL-12p40, IL-6, and $TNF-{\alpha}$) in vitro in bone marrow-derived dendritic cells stimulated with LPS.

Acknowledgement

Supported by : Chungnam National University

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