Pathological Laughing and Crying following Midbrain Infarction: Case Report and Literature Review

중뇌 경색 이후 발생한 병적 웃음과 울음 환자: 증례 보고 및 문헌 고찰

  • Moon, So-Ri (Department of Korean Rehabilitation Medicine, Dongguk University Bundang Oriental Hospital) ;
  • Park, Seo-Hyun (Department of Korean Rehabilitation Medicine, Dongguk University Bundang Oriental Hospital) ;
  • An, Seon-Joo (Department of Korean Rehabilitation Medicine, Dongguk University Bundang Oriental Hospital) ;
  • Keum, Dong-Ho (Department of Korean Rehabilitation Medicine, Dongguk University Bundang Oriental Hospital)
  • 문소리 (동국대학교 분당한방병원 한방재활의학과) ;
  • 박서현 (동국대학교 분당한방병원 한방재활의학과) ;
  • 안선주 (동국대학교 분당한방병원 한방재활의학과) ;
  • 금동호 (동국대학교 분당한방병원 한방재활의학과)
  • Received : 2018.09.15
  • Accepted : 2018.10.01
  • Published : 2018.10.31


Pathological laughing and crying (PLC) is a condition defined by relatively uncontrollable episodes of laughter, crying or both. PLC is an uncommon symptom usually caused by cerebral lesions. Midbrain involvement causing PLC is extremely unusual and the exact mechanism by which this condition develops is poorly understood. We recently experienced a 51-year-old woman who were diagnosed as PLC after midbrain infarction. She was treated by acupuncture, pulsed electromagnetic therapy (PEMT). After 6 weeks treatment, Pathological Laughter and Crying Scale (PLACS), Korean version of the Scale for the Assessment and Rating of Ataxia (K-SARA) are decreased and Korean version of Modified Barthel Index (K-MBI) is increased. Treatment of traditional Korean Medicine could be effective for stoke rehabilitation including post-stroke PLC. And we have considered mechanism of PLC associated with midbrain lesion, dysfunction of cortex-thalamus-hypothalamus-basal ganglia-mesencephalon and faciorespiratory nuclei pathways, cerebro-ponto-cerebellar pathways and damaged serotonergic neurotransmission can cause this based on recent neurobiology of emotion. To define exact mechanism and find effective treatment, further studies are needed.


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