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Treatment with ultra-dilutions of Arnica montana increases COX-2 expression and PGE2 secretion in mouse chondrocytes

생쥐 연골세포에 Arnica montana 처리에 따른 COX-2 발현과 PGE2 분비 비교

Kim, Yun Kyu;Yeo, Myeong Gu
김윤규;여명구

  • Received : 2019.01.15
  • Accepted : 2019.02.20
  • Published : 2019.02.28

Abstract

Objective: We studied the effects of 4x, 30x, 30c, and 200c homeopathic dilutions of A. montana on inflammation in primary cultured mouse chondrocytes. Methods: Examined expression of Coll-2 and COX-2, and secretion of PGE2. Results: Treatment with 4x, 30x, and 30c A. montana decreased mRNA expression of Coll-2 and 30x A. montana increased mRNA expression of COX-2, while treatment with 30x and 30c A. montana increased protein expression of COX-2. Treatment with the 30c A. montana increased release of PGE2. Conclusion: Treatment with A. montana induces dedifferentiation and inflammatory responses, including increased COX-2 expression and PGE2 secretion.

Keywords

Convergence;Arnica montana;Homeopathic medicine;COX-2;PGE2

Acknowledgement

Supported by : Nambu University, National Research Foundation of Korea (NRF)