The Association Between Serum Lipid profiles and periodontitis on Convergence

혈청지질분포와 치주질환간의 연관성에 관한 융합연구

Kim, Song Sook;Kim, Ji hyun

  • Received : 2018.09.17
  • Accepted : 2019.01.20
  • Published : 2019.01.28


The aim of this study was to evaluate the association between Lipid profiles and periodontal diseases in Korea adults. The date from the 2013, 2014 Korean National Health and Nutrition Survey were used, and 8,854 subjects over 30 years were included in the analysis. periodontal disease was assessed using the Community periodontal Index. Study participants with HDL between ${\leq}40mg/dL$(high) were 1.39 times(95% CI=1.16 to 1.66) as likely to have periodontal disease as those with normal levels and those with Triglyceride ${\geq}200mg/dL$(high) were 1.14 times(95% CI=1.02 to 1.27) as likely to have periodontal disease as those with normal levels. positive significant association was observed between serum lipid profiles and periodontal disease; however, further studies need to be conducted to understand the actual relationship between STC levels and periodontitis and to establish causality and directional association.


Convergence;Lipid profiles;Total cholesterol;LDL cholesterol;HDL cholesterol;Triglyceride;periodontitis


  1. A. C. E. Leite, V. M. d. A. Carneiro & M. D. C. M. Guimaraes. (2014). Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis. Brazilian Journal of Cardiovascular Surgery, 29(1), 69-77.
  2. D. Kinane. (1998). periodontal diseases' contributions to cardiovascular disease: an overview of potential mechanisms. Annals of periodontology, 3(1), 142-150. DOI : 10.1902/annals.1998.3.1.142
  3. O. Fentoglu F. Y. Kirzioglu, M. Ozdem. H. Kocak. R. Sutcu & T. Sert. (2012). proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment. Oral diseases, 18(3), 299-306. DOI : 10.1111/j.1601-0825.2011.01880.x
  4. J. H. Kim. (2016). Association between cigarette smoking status and eriodontal disease in adults: results from the 2012 Korea ational health and nutrition examination survey. Journal of Korean Academy of Oral Health, 40(2), 133-139. DOI : 10.11149/jkaoh.2016.40.2.133
  5. J. H. Kim. (2018). The Association between Obesity and peiodontal Diasease on Convergence Study. Jouranal of the Korea Convergence Scociety, 9(8), 71-76. DOI : 10.15207/JKCS.2018.9.8.071
  6. B. L. pihlstrom. B. S. Michalowicz & N. W. Johnson. (2005). periodontal diseases. The Lancet, 366(9499), 1809-1820. DOI : 10.1016/S0140-6736(05)67728-8
  7. T. Saxlin. L. Suominen-Taipale. A. Kattainen. J. Marniemi. M. Knuuttila & p. Ylostalo. (2008). Association between serum lipid levels and periodontal infection. Journal of clinical periodontology. 35(12), 1040-1047. DOI : 10.1111/j.1600-051X.2008.01331.x
  8. B. J. Goldman. (2000). Cecil Textbook of Medicine. philadelphia: WB Saunders.
  9. J. Katz. G. Chaushu & Y. Sharabi. (2001). On the association between hypercholesterolemia, cardiovascular disease and severe periodontal disease. Journal of clinical periodontology, 28(9), 865-868. DOI : 10.1034/j.1600-051x.2001.028009865.x
  10. S. Korhonen. T. Saxlin. L. Suominen. A. Jula. M. Knuuttila & p. Ylostalo. (2011). Serum cholesterol ratios and periodontal infection: results of the Health 2000 Survey. Journal of clinical periodontology, 38(9), 787-794. DOI : 10.1111/j.1600-051X.2011.01758.x
  11. W. Losche & F. Karapetow. A. pohl. C. pohl. T. Kocher. (2000). plasma lipid and blood glucose levels in patients with destructive periodontal disease. Journal of clinical periodontology, 27(8), 537-541. DOI : 10.1034/j.1600-051x.2000.027008537.x
  12. W. Losche. G. Marshal. S. Krause. T. Kocher & D. Kinane. (2005). Lipoprotein‐associated phospholipase A2 and plasma lipids in patients with destructive periodontal disease. Journal of clinical periodontology, 32(6), 640-644. DOI : 10.1111/j.1600-051X.2005.00725.x
  13. P. J. pussinen. T. Vilkuna-Rautiainen & G. Alfthan. T. palosuo. M. Jauhiainen & J. Sundvall. (2004). Severe periodontitis enhances macrophage activation via increased serum lipopolysaccharide. Arteriosclerosis, thrombosis, and vascular biology, 24(11), 2174-2180. DOI : 10.1161/01.ATV.0000145979.82184.9f
  14. S. Thapa & F. Wei. (2016). Association between high serum total cholesterol and periodontitis: National Health and Nutrition Examination Survey 2011 to 2012 Study of American adults. Journal of periodontology, 87(11), 1286-1294. DOI : 10.1902/jop.2016.150648
  15. K. Buhlin. A. Gustafsson. A. G. pockley. J. Frostegard & B. Klinge. (2003). Risk factors for cardiovascular disease in patients with periodontitis. European heart journal, 24(23), 2099-2107. DOI : 10.1016/j.ehj.2003.09.016
  16. A. C. Machado. M. R. Quirino & L. F. Nascimento. (2005). Relation between chronic periodontal disease and plasmatic levels of triglycerides, total cholesterol and fractions. Brazilian oral research, 19(4), 284-289. DOI : S1806-83242005000400009
  17. World Health Organization. (1995). Oral Health Surveys: Basic Methods. World Health Organization. [internet],[cited 2018 April 10], Available From:;jsessionid=A315AD83D978E38F13B7F95ECF034049?sequence=1.pdf.
  18. Committee for Guidelines for Management of Dyslipidemia. (2015). 2015 Korean Guidelines for Management of Dyslipidemia. Committee for Guidelines for Management of Dyslipidemia, 2287-2892. DOI : 10.12997/jla.2015.4.1.61
  19. H. D. Kim. D. M. Back. D. H. Go & D. I. Back. (2006). Journal of Academic Dental Health, 30(1), 46-56.
  20. H. J. Kang. (2015). A Study on Periodontal Disease and Tooth Loss in Metabolic Syndrome Patient. The Korean Society of Dental Hygiene Science, 15(4), 445-456
  21. A. Y. Ahn. (2015). The effects of atherosclerosis on periodontal disease and decision making model. Master's dissertation. Seoul National University, Seoul.
  22. V. Kalburgi. S. Leburu. S. (2014). Warad. Saliva as a surrogate to explore the association between lipid profiles and chronic periodontitis: A case-control study. Dental research journal, 11(6), 619-623.
  23. S. A. Banihashemrad. A. Moeintaghavi & A. Rafighdoost. (2008). Relationship between cholesterol and triglyceride blood values and periodontal parameters in patients of Mashhad health center. The New York state dental journal, 74(5), 65-66.
  24. J. Katz. M. Y. Flugelman. A. Goldberg & M. Heft. (2002). Association between periodontal pockets and elevated cholesterol and low density lipoprotein cholesterol levels. Jornal of periodontol, 73(5), 494-500. DOI : 10.1902/jop.2002.73.5.494
  25. J. Hamissi. M. Shahsavarani & H. A. Hamissi. (2011). A Comparison of Serum Lipid profile between periodontitis patients and Healthy Individuals. Iranian Red Crescent Medical Journal, 13(4), 283-284.
  26. A. Moeintaghavi. A. Haerian-Ardakani. M. Talebi-Ardakani & I. Tabatabaie. (2005). Hyperlipidemia in patients with periodontitis. Journal of Contemporary Fental Practice, 6(3), 78-85.
  27. L. G. Hagh. F. Zakavi. F. Hajizadeh & M. Saleki. (2014). The association between hyperlipidemia and periodontal infection. Iranian Red Crescent Medical Journal. 16(12), e6577. DOI : 10.1902/jop.2016.150648
  28. E. J. Marjanovic. H. N. Southern, P. Coates. J. E. Adams. T. Walsh & K. Horner. (2013). Do patients with osteoporosis have an increased prevalence of periodontal disease? A cross-sectional study. Osteoporosis international, 24(7), 1973-1979. DOI : 10.1007/s00198-015-3437-y