Medication-Related Osteonecrosis of the Jaw Associated with Palatal Bone and Soft Tissue Trauma: A Case Report

Singh, Harpreet;Saleh, Wafaa;Cha, Seunghee;Katz, Joseph;Ruprecht, Axel

  • Received : 2019.01.23
  • Accepted : 2019.03.19
  • Published : 2019.03.30


The aim of this case report is to present a case of 68-year-old male with a history of multiple myeloma and the intravenous use of Zometa (zoledronic acid) who had developed medication-related osteonecrosis of the jaw (MRONJ) following a hot pizza burn to the palate. Clinical and radiographic findings revealed grade 1 MRONJ of the right side of the hard palate. Soft tissue trauma and delayed epithelialization may be associated with some cases of MRONJ. Patients on anti-resorptive medications or anti-angiogenic drugs should be informed of the risk of bone exposure and subsequent MRONJ secondary to physical/chemical insults to the bone and soft tissue in the oral cavity.


Bisphosphonates;Medication related osteonecrosis of the jaw;Osteonecrosis;Zoledronic acid