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Effects of γ-aminobutyric acid and hydrochloric acid on growth performance, nutrient digestibility and fecal score of growing pigs

  • Ding, Zhenyu (Department of Animal Resource and Science, Dankook University) ;
  • Kim, Inho (Department of Animal Resource and Science, Dankook University)
  • Received : 2019.03.06
  • Accepted : 2019.06.24
  • Published : 2019.09.01

Abstract

A study was conducted to determine the effects of feeding ${\gamma}$-aminobutyric acid (GABA) and hydrochloric acid (HCl) on the growth performance, nutrient digestibility and fecal score in growing pigs. Ninety Duroc ${\times}$ (Landrace ${\times}$ Large Yorkshire) growing pigs with an average initial body weight (BW) of $25.51{\pm}1.63kg$ were randomly allotted to three treatment groups with 6 replications of 5 pigs per replicate pen for each treatment in a 6-week trial period. The treatments were as follows: 1) basal diet (CON); 2) basal diet with 0.05% GABA and 3) basal diet with 1% of a 10% HCl solution. The results showed that GABA supplementation significantly increased the average daily gain (ADG) (p < 0.05) compared with the control during week 4 and the overall experiment period (0 to 6 weeks). However, HCl supplementation had a numerical increase in the ADG compared with the control. The total tract digestibility of dry matter (DM) was greater in GABA group than the CON (p < 0.05). The supplementation of GABA and HCl in the diet of growing pigs had no significant effect on the fecal scores compared with the CON. Experimental results show that supplementation of 0.05% GABA in the diet of growing pigs had a positive effect on the ADG and DM digestibility in growing pigs.

References

  1. Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. 2006. Relaxation and immunity enhancement effects of ${\gamma}$-aminobutyric acid (GABA) administration in humans. Biofactors 26:201-208. https://doi.org/10.1002/biof.5520260305
  2. Barrow P, Fuller R, Newport M. 1977. Changes in the microflora and physiology of the anterior intestinal tract of pigs weaned at 2 days, with special reference to the pathogenesis of diarrhea. Infection and Immunity 18:586-595.
  3. Bongianni F, Mutolo D, Nardone F, Pantaleo T. 2006. GABAergic and glycinergic inhibitory mechanisms in the lamprey respiratory control. Brain Research 1090:134-145. https://doi.org/10.1016/j.brainres.2006.03.056
  4. Chen Z, Xie J, Hu M, Tang J, Shao Z, Li M. 2015. Protective effects of ${\gamma}$-aminobutyric acid (GABA) on the small intestinal mucosa in heat-stressed Wenchang chicken. Journal of Animal and Plant Sciences 25:78-87.
  5. Chen Z, Xie J, Wang B, Tang J. 2014. Effect of ${\gamma}$-aminobutyric acid on digestive enzymes, absorption function, and immune function of intestinal mucosa in heat-stressed chicken. Poultry Science 93:2490-2500. https://doi.org/10.3382/ps.2013-03398
  6. Cheng J, Bu D, Wang J, Sun X, Pan L, Zhou L, Liu W. 2014. Effects of rumen-protected ${\gamma}$-aminobutyric acid on performance and nutrient digestibility in heat-stressed dairy cows. Journal of Dairy Science 97:5599-5607. https://doi.org/10.3168/jds.2013-6797
  7. Dai S, Gao F, Zhang W, Song S, Xu X, Zhou G. 2011. Effects of dietary glutamine and gamma-aminobutyric acid on performance, carcass characteristics and serum parameters in broilers under circular heat stress. Animal Feed Science and Technology 168:51-60. https://doi.org/10.1016/j.anifeedsci.2011.03.005
  8. Dalvi A, Rodgers R. 2001. Anxiolytic effects of valproate and diazepam in mice are differentially sensitive to picrotoxin antagonism. Pharmacology Biochemistry and Behavior 68:23-32. https://doi.org/10.1016/S0091-3057(00)00408-1
  9. Erdo SL. 1985. Peripheral GABAergic mechanisms. Trends in Pharmacological Sciences 6:205-208. https://doi.org/10.1016/0165-6147(85)90096-3
  10. Fan Z, Deng J, Liu G, Cai H, He J, Wu M, Zheng F. 2007. Effects of ${\gamma}$-aminobutyric acid on the performance and internal hormone levels in growing pigs. Chinese Journal of Animal Nutrition 19:350-356.
  11. Giesting D, Easter R. 1986. Acidification status in swine diets. Feed management 37.
  12. Hu C, Gu L, Luan Z, Song J, Zhu K. 2012. Effects of montmorillonite-zinc oxide hybrid on performance, diarrhea, intestinal permeability and morphology of weanling pigs. Animal Feed Science and Technology 177:108-115. https://doi.org/10.1016/j.anifeedsci.2012.07.028
  13. Kelley KW. 1980. Stress and immune function: A bibliographic review. Annales de Recherches Veterinaires, INRA Editions 11:445-478.
  14. Khansari DN, Murgo AJ, Faith RE. 1990. Effects of stress on the immune system. Immunology Today 11:170-175. https://doi.org/10.1016/0167-5699(90)90069-L
  15. Kil D, Piao L, Long H, Lim J, Yun M, Kong C, Ju W, Lee H, Kim SY. 2005. Effects of organic or inorganic acid supplementation on growth performance, nutrient digestibility and white blood cell counts in weanling pigs. Asian-Australasian Journal of Animal Sciences 19:252-261. https://doi.org/10.5713/ajas.2006.252
  16. Krantis A, Kerr D. 1981. GABA induced excitatory responses in the guinea-pig small intestine are antagonized by bicuculline, picrotoxinin and chloride ion blockers. Naunyn-Schmiedeberg's Archives of Pharmacology 317:257-261. https://doi.org/10.1007/BF00503827
  17. Lewis AJ, Southern LL. 2000. Anatomy of the digestive system and nutritional physiology. Swine Nutrition, Second edition. pp. 51-84. CRC press, USA.
  18. NRC (National Research Council). 2012. Nutrient requirements of swine, 11th Ed. National Academy Press, Washington D.C., USA.
  19. Piqueras L, Martinez V. 2004. Peripheral GABAB agonists stimulate gastric acid secretion in mice. British journal of pharmacology 142:1038-1048. https://doi.org/10.1038/sj.bjp.0705876
  20. Ravindran V, Kornegay E. 1993. Acidification of weaner pig diets: a review. Journal of the Science of Food and Agriculture 62:313-322. https://doi.org/10.1002/jsfa.2740620402
  21. SAS Institute. 1996. SAS user's guide: Statistics. Version 7.0. SAS Insitute, Cary, USA.
  22. Shekhar A, Johnson PL, Sajdyk TJ, Fitz SD, Keim SR, Kelley PE, DiMicco JA. 2006. Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus. Journal of Neuroscience 26:9205-9215. https://doi.org/10.1523/JNEUROSCI.2491-06.2006
  23. Sissons JW. 1989. Potential of probiotic organisms to prevent diarrhea and promote digestion in farm animals-a review. Journal of the Science of Food and Agriculture 49:1-13. https://doi.org/10.1002/jsfa.2740490102
  24. Stratford TR, Kelley AE. 1999. Evidence of a functional relationship between the nucleus accumbens shell and lateral hypothalamus subserving the control of feeding behavior. Journal of Neuroscience 19:11040-11048. https://doi.org/10.1523/JNEUROSCI.19-24-11040.1999
  25. Wang D, Wang C, Liu H, Liu J, Ferguson JD. 2013. Effects of rumen-protected ${\gamma}$-aminobutyric acid on feed intake, lactation performance, and antioxidative status in early lactating dairy cows. Journal of Dairy Science 96:3222-3227. https://doi.org/10.3168/jds.2012-6285
  26. Wei XH, Qi XG, Xia D, Jiang JH. 2004. Effect of dietary ${\gamma}$-aminobutyric acid on finishing hogs growth and forage application. Ecology of Domestic Animal 25:10-12.
  27. Xu Y, Liu L, Long S, Pan L, Piao X. 2018. Effect of organic acids and essential oils on performance, intestinal health and digestive enzyme activities of weaned pigs. Animal Feed Science and Technology 235:110-119. https://doi.org/10.1016/j.anifeedsci.2017.10.012
  28. Zhang JY, Hu J, Kim IH. 2018. Effects of ${\gamma}$-aminobutyric acid (GABA) on growth performance, nutrient digestibility, blood profiles, meat quality, and backfat in finishing pigs. Korean Journal of Agricultural Science 45:105-113.
  29. Zhang Y, Xu R. 2006. Anatomy and histology of the gastrointestinal tract. The neonatal pig: Gastrointestinal Physiology and Nutrition.
  30. Zou XT, Hu JC, Cao DR, Dong JG. 2009. Effect of ${\gamma}$-aminobutyric acid on growth performance, antioxidation and hormones of HPA, HPT axis in growth-finishing swine in hot summer. Chinese Journal of Animal and Veterinary Sciences 8.